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Open AccessExploring the inverse relationship between serum total bilirubin and systemic immune-inflammation index: insights from NHANES data (2009–2018)
Bilirubin is known for its multifaceted attributes, including antioxidant, anti-inflammatory, immunomodulatory, and antiapoptotic properties. The systemic immune-inflammation index (SII) is a recent marker tha...
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Article
Association Between a Failed Prominence Eruption and the Drainage of Mass from Another Prominence
Sympathetic eruptions of solar prominences have been studied for decades, however, it is usually difficult to identify their causal links. Here, we present two failed prominence eruptions on 26 October 2022 an...
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Article
Associations between whole grains intake and new-onset hypertension: a prospective cohort study
Epidemiological evidences regarding the association between whole grain intake and the risk of new-onset hypertension are still controversial.
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Article
Open AccessCorrection to: Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children
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Article
Open AccessQuality of childcare and delayed child development in left-behind children in China
Inequalities in job opportunities and income prompts many Chinese parents to leave rural regions to work in urban regions. Their children are left behind in rural regions, subjected to worse quality of childca...
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Article
Open AccessExpert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children
Respiratory syncytial virus (RSV) is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 ...
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Article
Open AccessDam** signatures at JUNO, a medium-baseline reactor neutrino oscillation experiment
We study dam** signatures at the Jiangmen Underground Neutrino Observatory (JUNO), a medium-baseline reactor neutrino oscillation experiment. These dam** signatures are motivated by various new physics mod...
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Article
Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4
Adhesion G protein-coupled receptors (aGPCRs) constitute an evolutionarily ancient family of receptors that often undergo autoproteolysis to produce α and β subunits1–3. A tethered agonism mediated by the ‘Stache...
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Article
The identifiability of gene regulatory networks: the role of observation data
Identifying gene regulatory networks (GRN) from observation data is significant to understand biological systems. Conventional studies focus on improving the performance of identification algorithms. However, ...
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Article
Cancer metabolism and tumor microenvironment: fostering each other?
The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live. Metabolic reprogramming supports tumor cell high demand of biogenesis for their rapid pro...
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Article
Open AccessThe design and sensitivity of JUNO’s scintillator radiopurity pre-detector OSIRIS
The OSIRIS detector is a subsystem of the liquid scintillator filling chain of the JUNO reactor neutrino experiment. Its purpose is to validate the radiopurity of the scintillator to assure that all components...
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Article
Open AccessDexmedetomidine hydrochloride inhibits hepatocyte apoptosis and inflammation by activating the lncRNA TUG1/miR-194/SIRT1 signaling pathway
Liver injury seriously threatens the health of people. Meanwhile, dexmedetomidine hydrochloride (DEX) can protect against liver injury. However, the mechanism by which Dex mediates the progression of liver inj...
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Article
Open AccessStructural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2
Arrestins recognize different receptor phosphorylation patterns and convert this information to selective arrestin functions to expand the functional diversity of the G protein-coupled receptor (GPCR) superfam...
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Article
A gene-expression-based signature predicts survival in adults with T-cell lymphoblastic lymphoma: a multicenter study
We aimed to establish a discriminative gene-expression-based classifier to predict survival outcomes of T-cell lymphoblastic lymphoma (T-LBL) patients. After exploring global gene-expression profiles of progre...
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Article
Open AccessParoxetine suppresses reactive microglia-mediated but not lipopolysaccharide-induced inflammatory responses in primary astrocytes
Astrocytes are the most abundant glial cells in a brain that mediate inflammatory responses and provide trophic support for neurons. We have previously disclosed that paroxetine, a common selective serotonin r...
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Article
Open AccessTRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription
The existence of breast cancer stem cells (BCSCs) is a major reason underlying cancer metastasis and recurrence after chemotherapy and radiotherapy. Targeting BCSCs may ameliorate breast cancer relapse and the...
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Prognostic and predictive value of a microRNA signature in adults with T-cell lymphoblastic lymphoma
New prognostic factors are needed to establish indications for haematopoietic stem cell transplantation (HSCT) in first complete remission (CR1) for T-cell lymphoblastic lymphoma (T-LBL) patients. We used micr...
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Article
Intravenous formulation of Panax notoginseng root extract: human pharmacokinetics of ginsenosides and potential for perpetrating drug interactions
XueShuanTong, a lyophilized extract of Panax notoginseng roots (Sanqi) for intravenous administration, is extensively used as add-on therapy in the treatment of ischemic heart and cerebrovascular diseases and com...
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Article
Open AccessOutcomes of the national programme on prevention of mother-to-child transmission of hepatitis B virus in China, 2016–2017
In addition to providing free hepatitis B vaccine (HBvacc) series to all infants in China since 2005, the national programme on prevention of mother-to-child transmission (PMTCT) of hepatitis B virus (HBV) sta...
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Open AccessIdentification and characterization of the causative triatomine bugs of anaphylactic shock in Zhanjiang, China
Two health concerns primarily related to triatomine bugs are transmission of Trypanosoma cruzi through infective feces, and allergic reactions induced by triatomine bites. In the Southwestern United States, reduv...
