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Article
Open AccessMetabolic landscape and pathogenic insights: a comprehensive analysis of high ovarian response in infertile women undergoing in vitro fertilization
In the realm of assisted reproduction, a subset of infertile patients demonstrates high ovarian response following controlled ovarian stimulation (COS), with approximately 29.7% facing the risk of Ovarian Hype...
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Article
Open AccessThe role of nutrition in analysis of risk factors and short-term outcomes for late-onset necrotizing enterocolitis among very preterm infants: a nationwide, multicenter study in China
Necrotizing enterocolitis (NEC) is a serious gastrointestinal disease, primarily affects preterm newborns and occurs after 7 days of life (late-onset NEC, LO-NEC). Unfortunately, over the past several decades,...
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Article
CRF regulates pain sensation by enhancement of corticoaccumbal excitatory synaptic transmission
Both peripheral and central corticotropin-releasing factor (CRF) systems have been implicated in regulating pain sensation. However, compared with the peripheral, the mechanisms underlying central CRF system i...
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Article
Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application
Astragali Radix (A. Radix) is the dried root of Astragalus membranaceus var. mongholicus (Bge) Hsiao or Astragalus membranaceus (Fisch.) Bge., belonging to the family Leguminosae, which is mainly distributed in C...
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Article
Open AccessAntimicrobial resistance crisis: could artificial intelligence be the solution?
Antimicrobial resistance is a global public health threat, and the World Health Organization (WHO) has announced a priority list of the most threatening pathogens against which novel antibiotics need to be dev...
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Article
Open AccessConsensus for criteria of running a pediatric inflammatory bowel disease center using a modified Delphi approach
Good quality of care for inflammatory bowel disease (IBD) depends on high-standard management and facility in the IBD center. Yet, there are no clear measures or criteria for evaluating pediatric IBD (PIBD) ce...
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Article
An Investigation into a Throat Swab Collection Device for Children
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Article
Open AccessPhoton region and shadow of a rotating 5D black string
To explore the possible clues for the extra dimension from the Event Horizon Telescope (EHT) observations, we study the shadow of the rotating 5D black string in General Relativity (GR). Instead of investigati...
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Article
Open AccessAsarinin attenuates bleomycin-induced pulmonary fibrosis by activating PPARγ
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease that lacks effective treatment modalities. Once patients are diagnosed with IPF, their median survival is approximately 3–...
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Article
Comparing Arsenic-Containing Qinghuang Powder and Low-Intensity Chemotherapy in Elderly Patients with Acute Myeloid Leukemia
To compare the clinical effect of arsenic-containing Qinghuang Powder (QHP) and low-intensity chemotherapy (LIC) in treatment of elderly acute myeloid leukemia (eAML) patients.
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Article
Open AccessEffects of mixed oil emulsion on short-term clinical outcomes in premature infants: A prospective, multicenter, randomized controlled trial
This study compared the clinical effects of two different lipid emulsions in premature infants with gestational age < 32 weeks (VPI) or birth weight < 1500 g (VLBWI) to provide an evidence-based medicine basis...
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Article
A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments
Oxytocin (OT), a peptide hormone and neuromodulator, is involved in diverse physiological and pathophysiological processes in the central nervous system and the periphery. However, the regulation and functiona...
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Article
Bavachin protects against diet-induced hepatic steatosis and obesity in mice
Non-alcoholic fatty liver disease (NAFLD) is a major health concern worldwide, and the incidence of metabolic disorders associated with NAFLD is rapidly increasing because of the obesity epidemic. There are cu...
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Article
Open AccessCorrection: Analysis of risk factors for parenteral nutrition-associated cholestasis in preterm infants: a multicenter observational study
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Article
Open AccessDivergent projections of the prelimbic cortex mediate autism- and anxiety-like behaviors
The comorbidity of autism spectrum disorder and anxiety is common, but the underlying circuitry is poorly understood. Here, Tmem74-/- mice showed autism- and anxiety-like behaviors along with increased excitabili...
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Article
The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment
Gemcitabine plus cisplatin (GP) chemotherapy is the standard of care for nasopharyngeal carcinoma (NPC). However, the mechanisms underpinning its clinical activity are unclear. Here, using single-cell RNA sequ...
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Article
Study on grinding of SiCp/Al composites by micro-textured monolayer brazed diamond wheel
It is difficult to machine with high machining efficiency and surface integrity for SiCp/Al composite, especially for those with a high volume fraction of SiC. Here, we present monolayer brazed diamond grindin...
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Article
Open AccessAnalysis of risk factors for parenteral nutrition-associated cholestasis in preterm infants: a multicenter observational study
It is proposed that the development of parenteral nutrition-associated cholestasis (PNAC) was significantly associated with preterm birth, low birth weight, infection, etc.; however, the etiology and pathogene...
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Article
Biomarkers of aging
Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...
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Article
Open AccessA Cohort Study on Deficiency of ADA2 from China
Deficiency of adenosine deaminase 2 (DADA2), an autosomal recessive autoinflammatory disorder caused by biallelic loss-of-function variants in adenosine deaminase 2 (ADA2), has not been systemically investigat...
