84 Result(s)
within
**ao-Lu Sun
English
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Article
A novel oligo(N,O-donor) fluorescent probe possessed the CHEF effect for identification of aluminum ions in the environment
An oligo(N,O-donor) fluorescent probe SAS with high selectivity for Al3+ in DMF: H2O (V/V, 9:1) Tris–HCl solution was designed and synthesized. That is to say, the increase of Al3+ activates specific fluorescence...
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Glial growth factor 2 treatment alleviates ischemia and reperfusion-damaged integrity of the blood-brain barrier through decreasing Mfsd2a/caveolin-1-mediated transcellular and Pdlim5/YAP/TAZ-mediated paracellular permeability
The impairment of blood-brain barrier (BBB) integrity is the pathological basis of hemorrhage transformation and vasogenic edema following thrombolysis and endovascular therapy. There is no approved drug in th...
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PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy
Hypoxia-ischemia (HI) is one of the main causes of neonatal brain injury. Mitophagy has been implicated in the degradation of damaged mitochondria and cell survival following neonatal brain HI injury. Pleckstr...
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Open AccessCCT6A facilitates lung adenocarcinoma progression and glycolysis via STAT1/HK2 axis
Chaperonin Containing TCP1 Subunit 6 A (CCT6A) is a prominent protein involved in the folding and stabilization of newly synthesized proteins. However, its roles and underlying mechanisms in lung adenocarcinom...
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Open AccessCanagliflozin alleviates pulmonary hypertension by activating PPARγ and inhibiting its S225 phosphorylation
Pulmonary hypertension (PH) is a progressive fatal disease with no cure. Canagliflozin (CANA), a novel medication for diabetes, has been found to have remarkable cardiovascular benefits. However, few studies h...
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A multicenter propensity score analysis of significance of hepatic resection type for early-stage hepatocellular carcinoma
The impact of hepatic resection type on long-term oncological prognosis of patients with early-stage hepatocellular carcinoma (HCC) has not been systematically investigated. We sought to determine risk factors...
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In situ regulating intimately connected heterostructure by decomposition of solid solution oxides toward high-efficient water oxidation
Heterogeneous interfaces produced by inter-domain interactions on a nanoscale performs a crucial role in boosting the properties of an electrocatalyst toward oxygen evolution reaction (OER) process. Herein, a ...
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Article
Children with severe neurological symptoms associated with SARS-CoV-2 infection during Omicron pandemic in China
To analyze the clinical characteristics and outcomes of children with severe neurological symptoms associated with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection during the Omicron ...
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Open AccessMTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma
MYCN amplification is an independent poor prognostic factor in patients with high-risk neuroblastoma (NB). Further exploring the molecular regulatory mechanisms in MYCN-amplified NB will help to develop novel ...
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Article
Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids
A strong correlation between gut microbes and host health has been observed in numerous gut metagenomic cohort studies. However, the underlying mechanisms governing host–microbe interactions in the gut remain ...
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Open AccessMagnaporthe oryzae effector MoSPAB1 directly activates rice Bsr-d1 expression to facilitate pathogenesis
Fungal pathogens typically use secreted effector proteins to suppress host immune activators to facilitate invasion. However, there is rarely evidence supporting the idea that fungal secretory proteins contrib...
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Open AccessThe application of Foley catheter traction technique in extraperitoneal robot-assisted radical prostatectomy
To describe a technique to improve exposure of prostate during extraperitoneal robot-assisted radical prostatectomy (EP-RARP).
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Heat shock protein family A member 8 serving as a co-activator of transcriptional factor ETV4 up-regulates PHLDA2 to promote the growth of liver cancer
Heat shock protein family A member 8 (HSPA8) participates in the folding or degradation of misfolded proteins under stress and plays critical roles in cancer. In this study, we investigated the function of HSP...
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Open AccessThree-dimensional visualization and evaluation of hilar cholangiocarcinoma resectability and proposal of a new classification
As digital medicine has exerted profound influences upon diagnosis and treatment of hepatobiliary diseases, our study aims to investigate the accuracy of three-dimensional visualization and evaluation (3DVE) s...
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Article
Suppressing ASPARTIC PROTEASE 1 prolongs photosynthesis and increases wheat grain weight
The elongation of photosynthesis, or functional staygreen, represents a feasible strategy to propel metabolite flux towards cereal kernels. However, achieving this goal remains a challenge in food crops. Here ...
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Open Access18F-Florzolotau PET imaging captures the distribution patterns and regional vulnerability of tau pathology in progressive supranuclear palsy
Human post mortem studies have described the topographical patterns of tau pathology in progressive supranuclear palsy (PSP). Recent advances in tau PET tracers are expected to herald the next era of PSP inves...
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Paired quasi-periodic pulsations of hard X-ray emission in a solar flare
We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM) during the flare event on 2022 April 21 at 01:52 UT. Several subpeaks...
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Open AccessLoss of function of CMPK2 causes mitochondria deficiency and brain calcification
Brain calcification is a critical aging-associated pathology and can cause multifaceted neurological symptoms. Cerebral phosphate homeostasis dysregulation, blood-brain barrier defects, and immune dysregulatio...
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Defect-induced magnetism in χ3 borophene
Borophene is an emerging and promising two-dimensional material for spintronics applications. Nevertheless, the origin and controllability of its magnetism remain poorly understood, thereby hindering the furth...
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Open AccessDam** signatures at JUNO, a medium-baseline reactor neutrino oscillation experiment
We study dam** signatures at the Jiangmen Underground Neutrino Observatory (JUNO), a medium-baseline reactor neutrino oscillation experiment. These dam** signatures are motivated by various new physics mod...
