105 Result(s)

Article

ATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8⁺ T cells

Obesity shapes anti-tumor immunity through lipid metabolism; however, the mechanisms underlying how colorectal cancer (CRC) cells utilize lipids to suppress anti-tumor immunity remain unclear. Here, we show th...

Tu-**ong Huang, Hui-Si Huang, Shao-Wei Dong, Jia-Yan Chen… in Nature Communications (2024)

Article

Comprehensive meta-analysis of severe fever with thrombocytopenia syndrome virus infections in humans, vertebrate hosts and questing ticks

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne zoonosis caused by the SFTS virus (SFTSV). Understanding the prevalence of SFTSV RNA in humans, vertebrate hosts and ticks is crucia...

Ao-Long Xu, Han Xue, Yi Li, Xu Wang, **-**n Zheng, Fu-Yan Shi… in Parasites & Vectors (2024)

Article

Ceftazidime/avibactam versus polymyxin B in carbapenem-resistant Klebsiella pneumoniae infections: a propensity score-matched multicenter real-world study

In this retrospective observational multicenter study, we aimed to assess efficacy and mortality between ceftazidime/avibactam (CAZ/AVI) or polymyxin B (PMB)-based regimens for the treatment of Carbapenem-resi...

Hai-Hui Zhuang, Qiang Qu, Wen-Ming Long, Qin Hu, **ao-Li Wu, Ying Chen… in Infection (2024)

Article

LABS: linear amplification-based bisulfite sequencing for ultrasensitive cancer detection from cell-free DNA

Methylation-based liquid biopsies show promises in detecting cancer using circulating cell-free DNA; however, current limitations impede clinical application. Most assays necessitate substantial DNA inputs, po...

**ao-Long Cui, Ji Nie, Houxiang Zhu, Krissana Kowitwanich… in Genome Biology (2024)

Article

Correlation of distribution characteristics and dynamic changes of gut microbiota with the efficacy of immunotherapy in EGFR-mutated non-small cell lung cancer

The effects of gut microbiota and metabolites on the responses to immune checkpoint inhibitors (ICIs) in advanced epidermal growth factor receptor (EGFR) wild-type non-small cell lung cancer (NSCLC) have been stu...

Wei-Chi Luo, Shi-Qi Mei, Zi-Jian Huang, Zhi-Hong Chen… in Journal of Translational Medicine (2024)

Article

Intrinsic and extrinsic actions of human neural progenitors with SUFU inhibition promote tissue repair and functional recovery from severe spinal cord injury

Neural progenitor cells (NPCs) derived from human pluripotent stem cells(hPSCs) provide major cell sources for repairing damaged neural circuitry and enabling axonal regeneration after spinal cord injury (SCI)...

Yong-Long Chen, **ang-Lan Feng, Kin-Wai Tam, Chao-Yang Fan… in npj Regenerative Medicine (2024)

Article

Reductive soil disinfestation by mixing carbon nanotubes and mushroom residues to mitigate the continuous crop** obstacles for Lilium Brownii

Reductive soil disinfestation can effectively alleviate continuous crop** obstacles. The effects of mixing mushroom residues and carbon nanotubes on the structure and function of soil microbial communities a...

Ding‑Di Tu, Rong Song, Bei Yan, **-Feng Dai, Hua Fang, Qian-Qi Zheng, Yi Gu… in Crop Health (2024)

Article

Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking

Tactile and mechanical pain are crucial to our interaction with the environment, yet the underpinning molecular mechanism is still elusive. Endophilin A2 (EndoA2) is an evolutionarily conserved protein that is...

Man-**u **e, Ren-Chun Lai, Yi-Bin **ao, ** Zhang… in Military Medical Research (2024)

Article

Multi-modal molecular determinants of clinically relevant osteoporosis subtypes

Due to a rapidly aging global population, osteoporosis and the associated risk of bone fractures have become a wide-spread public health problem. However, osteoporosis is very heterogeneous, and the existing s...

Chunchun Yuan, **ang-Tian Yu, **g Wang, Bing Shu, **ao-Yun Wang… in Cell Discovery (2024)

Article

ThermomiR-377-3p-induced suppression of Cirbp expression is required for effective elimination of cancer cells and cancer stem-like cells by hyperthermia

In recent years, the development of adjunctive therapeutic hyperthermia for cancer therapy has received considerable attention. However, the mechanisms underlying hyperthermia resistance are still poorly under...

Tao-Yan Lin, Jun-Shuang Jia, Wei-Ren Luo… in Journal of Experimental & Clinical Cancer … (2024)

Article

Regulation of a vacuolar proton-pum** P-ATPase MdPH5 by MdMYB73 and its role in malate accumulation and vacuolar acidification

As the main organic acid in fruits, malate is produced in the cytoplasm and is then transported into the vacuole. It accumulates by vacuolar proton pumps, transporters, and channels, affecting the taste and fl...

**ao-Yu Huang, Ying **ang, Yu-Wen Zhao, Chu-Kun Wang, Jia-Hui Wang… in aBIOTECH (2023)

Article

Negative serum (1,3) -β-D-glucan has a low power to exclude Pneumocystis jirovecii pneumonia (PJP) in HIV-uninfected patients with positive qPCR

The current study evaluated the diagnostic performance of serum (1,3)-beta-D Glucan (BDG) in differentiating PJP from P. jirovecii-colonization in HIV-uninfected patients with P. jirovecii PCR-positive results.

Yuan Huang, Jie Yi, **g-**g Song… in Annals of Clinical Microbiology and Antimi… (2023)

Article

A model based on adipose and muscle-related indicators evaluated by CT images for predicting microvascular invasion in HCC patients

The presence of microvascular invasion (MVI) will impair the surgical outcome of hepatocellular carcinoma (HCC). Adipose and muscle tissues have been confirmed to be associated with the prognosis of HCC. We ai...

**n-Cheng Mao, Shuo Shi, Lun-Jie Yan, Han-Chao Wang, Zi-Niu Ding… in Biomarker Research (2023)

Article

Research on the development methodology for clinical practice guidelines for organic integration of traditional Chinese and Western medicine

Integrated traditional Chinese medicine (TCM) and Western medicine (WM) is a new medical science grounded in the knowledge bases of both TCM and WM, which then forms a unique modern medical system in China. In...

Ying-Hui **, Yan-** Wang, Ying-Lan **e, Gui-Hua Tian… in Military Medical Research (2023)

Article

Cerebral Infarction from Sick Sinus Syndrome (Based on SCN5A) via Patent Foramen Ovale

Shuang He, Lei Zhang, **ao-Yan Liu, **ao-Juan Ji… in Indian Journal of Pediatrics (2023)

Article

LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis

Inhibition of immunocyte infiltration and activation has been suggested to effectively ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) and its human ortholog recept...

Dan-Pei Li, Li Huang, Ran-Ran Kan, **ao-Yu Meng, Shu-Yun Wang… in Nature Communications (2023)

Article

Phase separation of α-crystallin-GFP protein and its implication in cataract disease

Cataract, the leading cause of blindness worldwide, is caused by crystallin protein aggregation within the protected lens environment. Phase separation has been implicated as an important mechanism of protein ...

Jie Shi, Ya-** Zhu, Rui-Yan Huang, Shao-Mei Bai, Yu-**ng Zheng… in Scientific Reports (2023)

Article

The safety of perioperative dexamethasone with antiemetic dosage in surgical patients with diabetes mellitus: a systematic review and meta-analysis

Dexamethasone is commonly used for antiemesis in surgical patients. It has been confirmed that long-term steroid use increases blood glucose level in both diabetic and non-diabetic patients, it is unclear how ...

Qian-Yun Pang, **g-Yun Wang, **ao-Long Liang, Yan Jiang… in Perioperative Medicine (2023)

Article

Comparison of the preoperative diagnostic accuracy of BIPSS versus MRI for Cushing disease: a single-centre experience

Cushing disease (CD) arises due to a pituitary corticotroph adenoma, which is the most common cause of Cushing syndrome (CS). Bilateral inferior petrosal sinus sampling (BIPSS) is a safe method for differentia...

Jian-Nan Mao, Hui-Ying Yan, Jie-Yu Chen, Chao-Long Yan, ** Li… in BMC Endocrine Disorders (2023)

Article

Independent predictive value of blood inflammatory composite markers in ovarian cancer: recent clinical evidence and perspective focusing on NLR and PLR

Ovarian cancer (OC) is one of the deadliest malignant tumors affecting women worldwide. The predictive value of some blood inflammatory composite markers in OC has been extensively reported. They can be used f...

Chuan-long Zhang, **ao-chen Jiang, Yi Li, Xue Pan… in Journal of Ovarian Research (2023)