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Article
Adaptation of a prey population to increasing predation risks
To test the hypotheses that multigenerational predation risk favors clones with longer postero-lateral spines and a larger body, and that fitness consequences of selection depend on both tested fitness variabl...
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Article
Four Labdane Diterpenoids from Leonurus japonicus
A new labdane diterpenoid, leojaponotin (1), and three known labdane diterpenoids (2–4), were isolated from Leonurus japonicus. Their structures were elucidated by spectroscopic analysis including NMR and MS.
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Article
Analysis of related factors influencing postoperative recurrence of adenomyosis treated with HIFU
To analyze the efficacy of high-intensity focused ultrasound (HIFU) for adenomyosis and postoperative recurrence and its influencing factors.
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Article
Impact of RISC fault position on stator thermal behavior in synchronous generators
Rotor interturn short circuit (RISC) is a common electrical fault in generators. Investigations about such fault on the rotor vibrations, magnetic field variations, and current/voltage changes have been widely...
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Article
Open AccessPropofol improves survival in a murine model of sepsis via inhibiting Rab5a-mediated intracellular trafficking of TLR4
Propofol is a widely used anesthetic and sedative, which has been reported to exert an anti-inflammatory effect. TLR4 plays a critical role in coordinating the immuno-inflammatory response during sepsis. Wheth...
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Article
Open AccessTP53 to mediate immune escape in tumor microenvironment: an overview of the research progress
Increasing evidence suggests that key cancer-causing driver genes continue to exert a sustained influence on the tumor microenvironment (TME), highlighting the importance of immunotherapeutic targeting of gene...
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Article
Open AccessEfficacy and safety of cladribine, low-dose cytarabine and venetoclax in relapsed/refractory acute myeloid leukemia: results of a pilot study
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Chapter and Conference Paper
Technology and Application of Fine Description for Complex Fault-Block Thin-Interbedded Condensate Gas Reservoirs
N gas field - typical complex fault-block thin-interbedded oil-ring condensate gas reservoirs. Due to the long development time of gas field, many problems like the low geological research level, the increasin...
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Article
Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer’s Disease mice via IGF1R/PI3K/AKT and SIRT1/AMPK Pathways
Patients with Alzheimer's disease have increased risk of develo** heart disease, which therefore highlights the need for strategies aiming at reducing Alzheimer's disease-related cardiovascular disease. Foli...
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Article
Open AccessIdentification of WUSCHEL-related homeobox gene and truncated small peptides in transformation efficiency improvement in Eucalyptus
The WUSCHEL-related Homeobox (WOX) genes, which encode plant-specific homeobox (HB) transcription factors, play crucial roles in regulating plant growth and development. However, the functions of WOX genes are li...
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Article
Open AccessNovel beagle model of gastric local fibrotic target lesions for the evaluation and training of endoscopic techniques
Novel endoscopic techniques used in the treatment of gastric lesions with local submucosal fibrosis need preclinical evaluation and training due to safety limitations. Therefore, the purpose of our study was t...
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Article
Peak early diastolic strain rate improves prediction of adverse cardiovascular outcomes in patients with ST-elevation myocardial infarction
The prognostic role of diastolic dysfunction measured by the circumferential peak early diastolic strain rate (PEDSR) on ST-elevation myocardial infarction (STEMI) is not completely established.
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Article
Open AccessDual targeted extracellular vesicles regulate oncogenic genes in advanced pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) tumours carry multiple gene mutations and respond poorly to treatments. There is currently an unmet need for drug carriers that can deliver multiple gene cargoes to targ...
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Article
Bioinspired PROTAC-induced macrophage fate determination alleviates atherosclerosis
Atherosclerosis is a major cause of death and disability in cardiovascular disease. Atherosclerosis associated with lipid accumulation and chronic inflammation leads to plaques formation in arterial walls and ...
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Article
Rapid molecular response to dasatinib in Ph-like acute lymphoblastic leukemia patients with ABL1 rearrangements: case series and literature review
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk subtype with a poor prognosis under conventional chemotherapy. Ph-like ALL has a similar gene expression profile to Philad...
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Article
Open AccessASCL2 induces an immune excluded microenvironment by activating cancer-associated fibroblasts in microsatellite stable colorectal cancer
Proficient mismatch repair or microsatellite stable (pMMR/MSS) colorectal cancers (CRCs) are vastly outnumbered by deficient mismatch repair or microsatellite instability-high (dMMR/MSI-H) tumors and lack a re...
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Article
Measurement of the 232Th(n,f) cross section in the 1–200 MeV range at the CSNS Back-n
The 232Th(n,f) cross section is very important in basic nuclear physics and applications based on the Th/U fuel cycle. Using the time-of-flight method and a multi-cell fast-fission ionization chamber, a novel mea...
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Article
Open AccessBroadly neutralizing human antibodies against Omicron subvariants of SARS-CoV-2
The COVID-19 pandemic continues to pose a significant worldwide threat to human health, as emerging SARS-CoV-2 Omicron variants exhibit resistance to therapeutic antibodies and the ability to evade vaccination...
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Article
Open AccessModified ulnar lengthening for correction of the Masada type 2 forearm deformity in hereditary multiple exostosis
Few articles have reported on the treatment of Masada type 2 forearm deformities in hereditary multiple exostosis, possibly because of the high redislocation rate and other complications. This study precisely ...
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Article
The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment
Gemcitabine plus cisplatin (GP) chemotherapy is the standard of care for nasopharyngeal carcinoma (NPC). However, the mechanisms underpinning its clinical activity are unclear. Here, using single-cell RNA sequ...
