85 Result(s)

Article

Disturbed intracellular folate homeostasis impairs autophagic flux and increases hepatocytic lipid accumulation

Metabolic associated fatty liver disease (MAFLD), a prevalent liver disorder affecting one-third of the global population, encompasses a spectrum ranging from fatty liver to severe hepatic steatosis. Both gene...

Wan-Yu Chi, Gang-Hui Lee, Ming-Jer Tang, Bing-Hung Chen, Wei-Ling Lin… in BMC Biology (2024)

Article

Common dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice

Dietary emulsifiers are linked to various diseases. The recent discovery of the role of gut microbiota–host interactions on health and disease warrants the safety reassessment of dietary emulsifiers through th...

Suraphan Panyod, Wei-Kai Wu, Chih-Ting Chang, Naohisa Wada… in Communications Biology (2024)

Article

Plastid genome and its phylogenetic implications of Asiatic Spiraea (Rosaceae)

Spiraea L. is a genus comprising approximately 90 species that are distributed throughout the northern temperate regions. China is recognized as the center of species diversity for this genus, hosting more than 7...

Shu-Yan Zhang, Hai-Fei Yan, Lei Wei, Tong-Jian Liu, Lin Chen, Gang Hao… in BMC Plant Biology (2024)

Article

NPM promotes hepatotoxin-induced fibrosis by inhibiting ROS-induced apoptosis of hepatic stellate cells and upregulating lncMIAT-induced TGF-β2

Liver fibrosis is caused by a variety of chronic liver injuries and has caused significant morbidity and mortality in the world with increasing tendency. Elucidation of the molecular mechanism of liver fibrosi...

Xue Ding, **n-Le Zhu, Dong-Hui Xu, Shuang Li, Qiong Yang, **an Feng… in Cell Death & Disease (2023)

Article

Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration

Age-related macular degeneration (AMD), characterized by the degeneration of retinal pigment epithelium (RPE) and photoreceptors, is the leading cause of irreversible vision impairment among the elderly. RPE s...

Wenchang Xu, **nqi Liu, Wenjuan Han, Keling Wu… in Cell Communication and Signaling (2023)

Article

A Common East Asian aldehyde dehydrogenase 2*2 variant promotes ventricular arrhythmia with chronic light-to-moderate alcohol use in mice

Chronic heavy alcohol use is associated with lethal arrhythmias. Whether common East Asian-specific aldehyde dehydrogenase deficiency (ALDH2*2) contributes to arrhythmogenesis caused by low level alcohol use rema...

An-Sheng Lee, Yen-Ling Sung, Szu-Hua Pan, Kuo-Tzu Sung… in Communications Biology (2023)

Article

Loss of function of CMPK2 causes mitochondria deficiency and brain calcification

Brain calcification is a critical aging-associated pathology and can cause multifaceted neurological symptoms. Cerebral phosphate homeostasis dysregulation, blood-brain barrier defects, and immune dysregulatio...

Miao Zhao, Hui-Zhen Su, Yi-Heng Zeng, Yuan Sun, **n-**n Guo, Yun-Lu Li… in Cell Discovery (2022)

Article

HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma

Extracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) i...

Qi-tao Chen, Zhi-yuan Zhang, Qiao-ling Huang, Hang-zi Chen… in Nature Metabolism (2022)

Article

Neutrophil to high-density lipoprotein cholesterol ratio predicts adverse cardiovascular outcomes in subjects with pre-diabetes: a large cohort study from China

This study aimed to examine whether the neutrophil to high-density lipoprotein cholesterol ratio (NHR) can predict cardiovascular outcomes in normoglycemic individuals with elevated fasting glucose levels.

Shuo-Lin Liu, Bao-Yu Feng, Qi-Rui Song, Ying-Mei Zhang… in Lipids in Health and Disease (2022)

Article

The crosstalk between endothelial cells and vascular smooth muscle cells aggravates high phosphorus-induced arterial calcification

Arterial calcification is highly prevalent, particularly in patients with end-stage renal disease (ESRD). The osteogenic differentiation of vascular smooth muscle cells (VSMCs) is the critical process for the ...

**ao Lin, Su-Kang Shan, Feng Xu, Jia-Yu Zhong, Feng Wu… in Cell Death & Disease (2022)

Article

Phase separation of insulin receptor substrate 1 drives the formation of insulin/IGF-1 signalosomes

As a critical node for insulin/IGF signaling, insulin receptor substrate 1 (IRS-1) is essential for metabolic regulation. A long and unstructured C-terminal region of IRS-1 recruits downstream effectors for pr...

**u Kui Gao, ** Sheng Rao, **ao **a Cong, Zu Kang Sheng, Yu Ting Sun… in Cell Discovery (2022)

Article

Author Correction: Detecting visually significant cataract using retinal photograph-based deep learning

Yih-Chung Tham, Jocelyn Hui Lin Goh, Ayesha Anees, **aofeng Lei… in Nature Aging (2022)