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Article
CRISPR-array-mediated imaging of non-repetitive and multiplex genomic loci in living cells
Dynamic imaging of genomic loci is key for understanding gene regulation, but methods for imaging genomes, in particular non-repetitive DNAs, are limited. We developed CRISPRdelight, a DNA-labeling system base...
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Article
Correction: Comparing Sonazoid contrast-enhanced ultrasound to contrast-enhanced CT and MRI for differentially diagnosing renal lesions: a prospective multicenter study
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Article
Open AccessA multicenter prospective study on the management of hepatoblastoma in children: a report from the Chinese Children’s Cancer Group
This study aimed to identify survival risk factors in Chinese children with hepatoblastoma (HB) and assess the effectiveness of the new treatment protocol proposed by the Chinese Children’s Cancer Group (CCCG)...
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Article
Pedigree Analysis of Nonclassical Cholesteryl Ester Storage Disease with Dominant Inheritance in a LIPA I378T Heterozygous Carrier
Cholesterol ester storage disorder (CESD; OMIM: 278,000) was formerly assumed to be an autosomal recessive allelic genetic condition connected to diminished lysosomal acid lipase (LAL) activity due to LIPA gene a...
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Article
Open AccessP. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway
Benign prostatic hyperplasia (BPH) is the most common disease in elderly men. There is increasing evidence that periodontitis increases the risk of BPH, but the specific mechanism remains unclear. This study a...
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Article
Comparing Sonazoid contrast-enhanced ultrasound to contrast-enhanced CT and MRI for differentially diagnosing renal lesions: a prospective multicenter study
To evaluate the diagnostic performance of contrast-enhanced (CE) ultrasound using Sonazoid (SNZ–CEUS) by comparing with contrast-enhanced computed tomography (CE–CT) and contrast-enhanced magnetic resonance im...
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Article
Adult type I Gaucher disease with splenectomy caused by a compound heterozygous GBA1 mutation in a Chinese patient: a case report
Gaucher disease (GD) is an autosomal recessive ailment resulting from glucocerebrosidase deficiency caused by a mutation in the GBA1 gene, leading to multi-organ problems in the liver, spleen, and bone marrow. In...
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Article
Open AccessDownregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
GPX8, which is found in the endoplasmic reticulum lumen, is a member of the Glutathione Peroxidases (GPXs) family. Its role in hepatocellular carcinoma (HCC) is unknown.
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Chapter and Conference Paper
Research on the Method of Inverting Indicator Diagram with Electrical Parameters of Pum** Unit Based on Neural Network
In view of the problems that the load cell used to test the indicator diagram in the pum** unit is easy to drift in the long term and needs manual regular maintenance, a new method is proposed to demonstrate...
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Chapter and Conference Paper
Scale Prediction and Field Application of ASP Flooding Production Well
The scaling of produced Wells is one of the main problems faced by ASP flooding technology. At present, the determination is mainly based on the pH value of produced liquid and the concentration of scaling ion...
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Article
Open AccessThe hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice
Depression is two-to-three times more frequent among women. The hypothalamus, a sexually dimorphic area, has been implicated in the pathophysiology of depression. Neuroinflammation-induced hypothalamic dysfunc...
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Article
Quasi-in situ immersion characterization of grain structures evolution revealing the corrosion resistance of Al-Zn-Mg alloys with various Sc additions
Al-Zn-Mg alloys have been investigated for the effect of Sc additions on corrosion resistance. The addition of Sc to Al-Zn-Mg alloys can more effectively retard recrystallisation during heat treatment and impr...
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Article
Open AccessIdentification of WUSCHEL-related homeobox gene and truncated small peptides in transformation efficiency improvement in Eucalyptus
The WUSCHEL-related Homeobox (WOX) genes, which encode plant-specific homeobox (HB) transcription factors, play crucial roles in regulating plant growth and development. However, the functions of WOX genes are li...
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Article
Open AccessVH-CH1 switch region-inserting multispecific antibody designs and their efficacy against SARS-CoV-2 in vitro and in vivo
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Article
Ultrathin GaN Crystal Realized Through Nitrogen Substitution of Layered GaS
GaN has been demonstrated as an important wide-bandgap semiconductor in many applications, especially in optoelectronic and high-power electronics. Two-dimensional (2D) GaN, with increased bandgap compared to ...
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Article
The role and mechanisms of microvascular damage in the ischemic myocardium
Following myocardial ischemic injury, the most effective clinical intervention is timely restoration of blood perfusion to ischemic but viable myocardium to reduce irreversible myocardial necrosis, limit infar...
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Article
Dual-loading strategy to construct Au-BiOBr-TiO2 photocatalysts for fast and efficient degradation of xanthates under visible light
With the advancement of mining operations, xanthate as an essential flotation reagent is unavoidably released into natural water bodies through flotation effluent. To protect the surrounding environment of min...
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Article
Effect of micro-do** yttrium oxide on hot-press sintering of boron carbide
Dense B4C composites were fabricated by hot-press sintering using B4C and nano-scale yttrium oxide as the raw materials. The effects of Y2O3 content and sintering temperature on the microstructure and mechanical ...
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Article
Measurement of the 232Th(n,f) cross section in the 1–200 MeV range at the CSNS Back-n
The 232Th(n,f) cross section is very important in basic nuclear physics and applications based on the Th/U fuel cycle. Using the time-of-flight method and a multi-cell fast-fission ionization chamber, a novel mea...
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Article
Open AccessDevelopment of a deep pathomics score for predicting hepatocellular carcinoma recurrence after liver transplantation
Tumor recurrence after liver transplantation (LT) impedes the curative chance for hepatocellular carcinoma (HCC) patients. This study aimed to develop a deep pathomics score (DPS) for predicting tumor recurren...
