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Article
Open AccessSynthetic macrolides overcoming MLSBK-resistant pathogens
Conventional macrolide-lincosamide-streptogramin B-ketolide (MLSBK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base ...
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Article
Open AccessNLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis
Members of the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing (NLRP) family regulate various physiological and pathological processes. However, none have been shown ...
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Article
A human-specific insertion promotes cell proliferation and migration by enhancing TBC1D8B expression
Human-specific insertions play important roles in human phenotypes and diseases. Here we reported a 446-bp insertion (Insert-446) in intron 11 of the TBC1D8B gene, located on chromosome X, and traced its origin t...
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Chapter and Conference Paper
Application and Optimization of Concentric Pipe Jet Pump Drainage Gas Production Technology in the South Area of Sulige Gas Field
Gas Wells in the south area of Sulige Gas field generally produce water and accumulated liquid. The main drainage gas recovery measures such as plunger gas lift and foam drainage have low efficiency in the wat...
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Article
Open AccessDynamic single-cell map** unveils Epstein‒Barr virus-imprinted T-cell exhaustion and on-treatment response
Epstein‒Barr virus (EBV)-associated gastric cancer (GC) manifests an intriguing immunotherapy response. However, the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined...
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Article
Electrical properties of PVDF films fabricated by direct ink writing
In this study, direct ink writing (DIW) was applied to preparing polyvinylidene fluoride (PVDF) film. The rheological properties of inks were studied, and the influence of process parameters on material proper...
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Article
Open AccessElectrochemistry-assisted selective butadiene hydrogenation with water
Alkene feedstocks are used to produce polymers with a market expected to reach 128.4 million metric tons by 2027. Butadiene is one of the impurities poisoning alkene polymerization catalysts and is usually rem...
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Article
Open AccessMesoporous Pt@Pt-skin Pt3Ni core-shell framework nanowire electrocatalyst for efficient oxygen reduction
The design of Pt-based nanoarchitectures with controllable compositions and morphologies is necessary to enhance their electrocatalytic activity. Herein, we report a rational design and synthesis of anisotropi...
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Article
Sulfonylcalix[4]arene-based metal-organic polyhedra with hierarchical porous structures for efficient Xe/Kr separation
Multiple space from the interior of metal-organic polyhedra (MOPs), the exterior among MOPs, and the inherent nature of big organic molecules makes MOPs as promising platform with hierarchical porous structure...
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Article
Stem Cell-derived Extracellular Vesicles: A Promising Nano Delivery Platform to the Brain?
A very important cause of the frustration with drug therapy for central nervous system (CNS) diseases is the failure of drug delivery. The blood–brain barrier (BBB) prevents most therapeutic molecules from ent...
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Article
Open AccessExpression and function of myelin expression factor 2 in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignant tumours in the world and has a high mortality rate. However, the pathogenesis of HCC remains unclear. This study aimed to investigate the pote...
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Article
Open AccessAndrographolide ameliorates hepatic steatosis by suppressing FATP2-mediated fatty acid uptake in mice with nonalcoholic fatty liver disease
Excessive intrahepatocellular lipid accumulation or steatosis is caused by abnormal lipid metabolism and a common character of nonalcoholic fatty liver disease (NAFLD), which may progress into cirrhosis and he...
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Article
Wear and corrosion resistance of CoCrNi composite coatings by laser cladding
Two kinds of CoCrNi composite coatings, CoCrNiMo and CoCrNiMoBC, were prepared by laser cladding on the base metal of 304 stainless steel. The wear and corrosion properties of the coatings were studied by wear...
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Article
Identification of resistance of Guangxi (Oryza rufipogon Griff.) to white-backed planthopper with stem evaluation method
White-backed planthopper (WBPH) is a devastating pest of rice, which significantly reduces production and causes millions of dollars in losses worldwide annually. Screening of germplasm resources with resistan...
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Article
Open AccessTargeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer’s disease
NLRP3 inflammasome-mediated neuroinflammation plays a critical role in the pathogenesis and development of Alzheimer’s disease (AD). Microglial autophagic degradation not only decreases the deposits of extrace...
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Article
Shoot organogenesis and somatic embryogenesis in leaf tissue of Pulsatilla tongkangensis Y.N. Lee & T.C. Lee
Leaf material explants of Pulsatilla tongkangensis Y. N. Lee & T. C. Lee were used to regenerate plants of this endangered species by somatic embryogenesis and organogenesis from meristematic nodules, induced by ...
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Article
IFN-α inhibits HBV transcription and replication by promoting HDAC3-mediated de-2-hydroxyisobutyrylation of histone H4K8 on HBV cccDNA minichromosome in liver
The epigenetic modification of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) plays a crucial role in cccDNA transcription and viral persistence. Interferon-α (IFN-α) is a pivotal agent agains...
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Article
Catalyst particle shapes and pore structure engineering for hydrodesulfurization and hydrodenitrogenation reactions
Catalyst particle shapes and pore structure engineering are crucial for alleviating internal diffusion limitations in the hydrodesulfurization (HDS)/hydrodenitrogenation (HDN) of gas oil. The effects of cataly...
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Article
Cyr61 Alleviates Cholangitis by Inhibiting Cytotoxic Effects of CD8+ T Cells on Biliary Epithelial Cells
Primary biliary cholangitis (PBC) is a chronic progressive cholestatic liver disease. In recent years, researchers have found that cysteine-rich angiogenic inducer 61 (Cyr61, also known as CCN1) has a potentia...
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Article
Decreased left amygdala functional connectivity by cognitive-co** therapy in obsessive-compulsive disorder
It is of great clinical importance to explore more efficacious treatments for OCD. Recently, cognitive-co** therapy (CCT), mainly focusing on recognizing and co** with a fear of negative events, has been r...
