64 Result(s)

Article

DDRGK1-mediated ER-phagy attenuates acute kidney injury through ER-stress and apoptosis

Acute kidney injury (AKI) constitutes a prevalent clinical syndrome characterized by elevated morbidity and mortality rates, emerging as a significant public health issue. This study investigates the interplay...

Haijiao **, Yuanting Yang, Xuying Zhu, Yin Zhou, Yao Xu, Jialin Li… in Cell Death & Disease (2024)

Article

Genome and whole-genome resequencing of Cinnamomum camphora elucidate its dominance in subtropical urban landscapes

Lauraceae is well known for its significant phylogenetic position as well as important economic and ornamental value; however, most evergreen species in Lauraceae are restricted to tropical regions. In contras...

Danqing Li, Han-Yang Lin, **uyun Wang, Bo Bi, Yuan Gao, Lingmei Shao… in BMC Biology (2023)

Article

Phagotrophic protists preserve antibiotic-resistant opportunistic human pathogens in the vegetable phyllosphere

Food safety of leafy greens is an emerging public health issue as they can harbor opportunistic human pathogens (OHPs) and expose OHPs to consumers. Protists are an integral part of phyllosphere microbial ecos...

Chenshuo Lin, Li-Juan Li, Kexin Ren, Shu-Yi-Dan Zhou, Alain Isabwe… in ISME Communications (2023)

Article

SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of nasopharyngeal carcinoma through regulating the nucleus translocation of YAP1

Dysregulation of serine/arginine splicing factors (SRSFs) and abnormal alternative splicing (AS) have been widely implicated in various cancers but scarcely investigated in nasopharyngeal carcinoma (NPC). Here...

**ao-Chen Xu, Jia-**n Jiang, Ya-Qing Zhou, Shuai He, Yang Liu… in Cell Death & Disease (2023)

Article

Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1

Tumor-derived exosomes and their contents promote cancer metastasis. Phosphoglycerate mutase 1 (PGAM1) is involved in various cancer-related processes. Nevertheless, the underlying mechanism of exosomal PGAM1 ...

Jun-qi Luo, Tao-wei Yang, Jun Wu, Hou-hua Lai, Li-bin Zou… in Cell Death & Disease (2023)

Article

Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions

Protein-biomolecule interactions play pivotal roles in almost all biological processes. For a biomolecule of interest, the identification of the interacting protein(s) is essential. For this need, although man...

He-Wei Jiang, Hong Chen, Yun-**ao Zheng, Xue-Ning Wang… in Science China Life Sciences (2023)

Article

Biomarkers of aging

Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...

Hainan Bao, Jiani Cao, Mengting Chen, Min Chen, Wei Chen… in Science China Life Sciences (2023)

Article

Initiation of scutellum-derived callus is regulated by an embryo-like developmental pathway in rice

In rice (Oryza sativa) tissue culture, callus can be induced from the scutellum in embryo or from the vasculature of non-embryonic organs such as leaves, nodes, or roots. Here we show that the auxin signaling pat...

Fu Guo, Hua Wang, Guiwei Lian, Gui Cai, Wu Liu, Haidao Zhang… in Communications Biology (2023)

Article

Population genomic analysis provides evidence of the past success and future potential of South China tiger captive conservation

Among six extant tiger subspecies, the South China tiger (Panthera tigris amoyensis) once was widely distributed but is now the rarest one and extinct in the wild. All living South China tigers are descendants of...

Chen Wang, Dong-Dong Wu, Yao-Hua Yuan, Meng-Cheng Yao, Jian-Lin Han… in BMC Biology (2023)

Article

TM4SF1 upregulates MYH9 to activate the NOTCH pathway to promote cancer stemness and lenvatinib resistance in HCC

TM4SF1, a member of the transmembrane 4 superfamily, is crucial for both healthy and malignant human tissues. The significant function of TM4SF1 in the incidence and progression of cancer has been widely recog...

Si-bo Yang, Zi-han Zhou, ** Lei, **ao-wen Li, Qian Chen, Bo Li… in Biology Direct (2023)

Article

Molecular and cellular evolution of the amygdala across species analyzed by single-nucleus transcriptome profiling

The amygdala, or an amygdala-like structure, is found in the brains of all vertebrates and plays a critical role in survival and reproduction. However, the cellular architecture of the amygdala and how it has ...

Bin Yu, Qianqian Zhang, Lin Lin, **n Zhou, Wenji Ma, Shaonan Wen… in Cell Discovery (2023)

Article

A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein

The emerging SARS-CoV-2 variants, commonly with many mutations in S1 subunit of spike (S) protein are weakening the efficacy of the current vaccines and antibody therapeutics. This calls for the variant-proof ...

Wei Pang, Ying Lu, Yan-Bo Zhao, Fan Shen, Chang-Fa Fan, Qian Wang… in Cell Research (2022)

Article

Correction: Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development

Wan-jun Yang, Rong-chang Cao, Wang **ao, **ao-lou Zhang, Hao Xu… in Cell Death & Disease (2022)

Article

Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development

Noninflammatory clearance of dying cells by professional phagocytes, termed efferocytosis, is fundamental in both homeostasis and inflammatory fibrosis disease but has not been confirmed to occur in chronic pa...

Wan-jun Yang, Rong-chang Cao, Wang **ao, **ao-lou Zhang, Hao Xu… in Cell Death & Disease (2022)

Article

Targeting the ALK–CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex

Poly(ADP-ribose) polymerase (PARP) inhibitors have demonstrated promising clinical activity in multiple cancers. However, resistance to PARP inhibitors remains a substantial clinical challenge. In the present ...

Yu-Yi Chu, Mei-Kuang Chen, Yongkun Wei, Heng-Huan Lee, Weiya **a… in Nature Cancer (2022)

Article

Phase separation of insulin receptor substrate 1 drives the formation of insulin/IGF-1 signalosomes

As a critical node for insulin/IGF signaling, insulin receptor substrate 1 (IRS-1) is essential for metabolic regulation. A long and unstructured C-terminal region of IRS-1 recruits downstream effectors for pr...

**u Kui Gao, ** Sheng Rao, **ao **a Cong, Zu Kang Sheng, Yu Ting Sun… in Cell Discovery (2022)