26 Result(s)
within
**ao-Lei Wu
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessMyricetin mitigates motor disturbance and decreases neuronal ferroptosis in a rat model of Parkinson’s disease
Ferroptosis is an iron-dependent cell death form characterized by reactive oxygen species (ROS) overgeneration and lipid peroxidation. Myricetin, a flavonoid that exists in numerous plants, exhibits potent ant...
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Open AccessA ResNet mini architecture for brain age prediction
The brain presents age-related structural and functional changes in the human life, with different extends between subjects and groups. Brain age prediction can be used to evaluate the development and aging of...
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Open AccessBoosting thermoelectric performance of single-walled carbon nanotubes-based films through rational triple treatments
Single-walled carbon nanotubes (SWCNTs)-based thermoelectric materials, valued for their flexibility, lightweight, and cost-effectiveness, show promise for wearable thermoelectric devices. However, their therm...
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Article
Open AccessMachine learning-based extrachromosomal DNA identification in large-scale cohorts reveals its clinical implications in cancer
The clinical implications of extrachromosomal DNA (ecDNA) in cancer therapy remain largely elusive. Here, we present a comprehensive analysis of ecDNA amplification spectra and their association with clinical ...
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Open AccessTranscriptome-wide association analyses reveal the impact of regulatory variants on rice panicle architecture and causal gene regulatory networks
Panicle architecture is a key determinant of rice grain yield and is mainly determined at the 1-2 mm young panicle stage. Here, we investigated the transcriptome of the 1-2 mm young panicles from 275 rice vari...
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Open AccessThe liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer
Colorectal cancer (CRC) patients with liver metastases usually obtain less benefit from immunotherapy, and the underlying mechanisms remain understudied. Here, we identify that fibrinogen-like protein 1 (FGL1)...
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Open AccessAutonomic function and motor subtypes in Parkinson’s disease: a multicentre cross-sectional study
Autonomic symptoms (AS) are critical in Parkinson’s disease (PD). We aimed to determine the relative significance of clinical factors allowing predictions about incidence of AS, and examine AS profiles among P...
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Open AccessTRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca2+ leakage
Intracellular Ca2+ dysregulation is a key marker in septic cardiac dysfunction; however, regulation of the classic Ca2+ regulatory modules cannot successfully abolish this symptom. Here we show that the knockout ...
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Open AccessA saturated map of common genetic variants associated with human height
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sa...
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Open AccessComprehensive profiling of 1015 patients’ exomes reveals genomic-clinical associations in colorectal cancer
The genetic basis of colorectal cancer (CRC) and its clinical associations remain poorly understood due to limited samples or targeted genes in current studies. Here, we perform ultradeep whole-exome sequencin...
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Open AccessGiant anisotropic thermal expansion actuated by thermodynamically assisted reorientation of imidazoliums in a single crystal
Materials demonstrating unusual large positive and negative thermal expansion are fascinating for their potential applications as high-precision microscale actuators and thermal expansion compensators for norm...
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Article
Open AccessA ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours
Accumulating evidence indicates that the zinc-finger transcription factor ZEB1 is predominantly expressed in the stroma of several tumours. However, the role of stromal ZEB1 in tumour progression remains unexp...
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Open AccessLiver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases
Cardiovascular and metabolic disease (CMD) remains a main cause of premature death worldwide. Berberine (BBR), a lipid-lowering botanic compound with diversified potency against metabolic disorders, is a promi...
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Open AccessIn Vivo Imaging Markers for Prediction of Radiotherapy Response in Patients with Nasopharyngeal Carcinoma: RESOLVE DWI versus DKI
In this prospective study, we compared the performance of readout segmentation of long variable echo trains of diffusion-weighted imaging (RESOLVE DWI) and diffusion kurtosis imaging (DKI) for the prediction o...
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Article
Open AccessRivaroxaban does not influence hemorrhagic transformation in a diabetes ischemic stroke and endovascular thrombectomy model
Managing endovascular thrombectomy (ET) in diabetic ischemic stroke (IS) with novel anticoagulants is challenging due to putative risk of intracerebral hemorrhage. The study evaluates increased hemorrhagic tra...
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Article
Open AccessOptically Tunable Gratings Based on Coherent Population Oscillation
We theoretically study the optically tunable gratings based on a L-type atomic medium using coherent population oscillations from the angle of reflection and transmission of the probe field. Adopting a standin...
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Article
Open AccessUpdating the Geologic Barcodes for South China: Discovery of Late Archean Banded Iron Formations in the Yangtze Craton
Banded iron formations (BIFs) in Archean cratons provide important “geologic barcodes” for the global correlation of Precambrian sedimentary records. Here we report the first finding of late Archean BIFs from ...
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Article
Open AccessMechanistic Investigation on ROS Resistance of Phosphorothioated DNA
Phosphorothioated DNA (PT-DNA) exhibits a mild anti-oxidant property both in vivo and in vitro. It was found that 8-OHdG and ROS levels were significantly lower in dnd+ (i.e. S+) E. coli., compared to a dnd− (i.e...
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Article
Open AccessOsthole inhibits histamine-dependent itch via modulating TRPV1 activity
Osthole, an active coumarin isolated from Cnidium monnieri (L.) Cusson, has long been used in China as an antipruritic herbal medicine; however, the antipruitic mechanism of osthole is unknown. We studied the mol...
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Open AccessEffects of hydrogen-rich water on depressive-like behavior in mice
Emerging evidence suggests that neuroinflammation and oxidative stress may be major contributors to major depressive disorder (MDD). Patients or animal models of depression show significant increase of proinfl...
