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Article
Structural design and simulation of PDMS/SiC functionally graded substrates for applications in flexible hybrid electronics
Flexible hybrid electronics possess significant potential for applications in biomedical and wearable devices due to their advantageous properties of good ductility, low mass, and portability. However, they of...
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Article
Genome-wide identification and expression analysis of the BZR gene family in Zanthoxylum armatum DC and functional analysis of ZaBZR1 in drought tolerance
In this study, six ZaBZRs were identified in Zanthoxylum armatum DC, and all the ZaBZRs were upregulated by abscisic acid (ABA) and drought. Overexpression of ZaBZR1 enhanced the drought tolerance of transgenic N...
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Article
Induction of secondary cell wall biosynthesis genes and their regulators by melatonin in Glycine max
Plant lodging severely reduced crop yield and quality. Different plant growth regulators (PGRs) have been applied to improve lodging resistance through the regulation of physiological changes, especially on th...
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Article
Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice
Anxiety disorders are the most common psychiatric condition, but the etiology of anxiety disorders remains largely unclear. Our previous studies have shown that neuroplastin 65 deficiency (NP65−/−) mice exhibit a...
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Article
Open AccessThe risk of herpes zoster is positively associated with obesity, especially morbid obesity
This study aimed to investigate the association between obesity and herpes zoster (HZ) occurrence. This study used data covering 2 million people in Taiwan in 2000, which were obtained from the National Health...
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Article
Open AccessLandform and lithospheric development contribute to the assembly of mountain floras in China
Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...
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Article
TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-β1/Smad3 Signaling Pathway
Intestinal fibrosis is a refractory complication of inflammatory bowel disease (IBD). Tumor necrosis factor ligand-related molecule-1A (TL1A) is important for IBD-related intestinal fibrosis in a dextran sodiu...
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Article
2023: Weather and Climate Extremes Hitting the Globe with Emerging Features
Globally, 2023 was the warmest observed year on record since at least 1850 and, according to proxy evidence, possibly of the past 100 000 years. As in recent years, the record warmth has again been accompanied...
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Article
High-grade transformation of head and neck adenoid cystic carcinoma demonstrates distinctive clinicopathological features and an unfavorable prognosis: a matched case-control study of the largest series in China
Amidst the rarity of High-grade transformation (HGT) in adenoid cystic carcinoma (ACC), this study offers unprecedented insights into its aggressive nature and clinical implications.
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Article
GSK-126 Attenuates Cell Apoptosis in Ischemic Brain Injury by Modulating the EZH2-H3K27me3-Bcl2l1 Axis
Whether epigenetic modifications participate in the cell apoptosis after ischemic stroke remains unclear. Histone 3 tri-methylation at lysine 27 (H3K27me3) is a histone modification that leads to gene silencin...
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Article
Fabrication of a novel bone adhesive (crosslinked phytic acid-gelatin coordinated with magnesium phosphate and calcined dolomite, and montmorillonite) for enhancing adhesion strength and biocompatibility
Bone adhesives are known as a promising fracture treatment material because they can quickly heal broken bones. However, the existing bone adhesives have the disadvantages of weak binding ability to bone tissu...
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Article
Value of orthogonal axial MR images in preoperative T staging of gastric cancer
To assess the value of orthogonal axial images (OAI) of MRI in gastric cancer T staging.
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Article
PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy
Hypoxia-ischemia (HI) is one of the main causes of neonatal brain injury. Mitophagy has been implicated in the degradation of damaged mitochondria and cell survival following neonatal brain HI injury. Pleckstr...
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Article
Identification and expression analysis of Jr4CLs gene family based on transcriptome and physiological data in walnut (Juglans regia)
Shoot shriveling severely threaten growth and development of deciduous trees in northern hemisphere, its essence is imbalance of water absorption and evaporation in the branches. In this study, the physiologic...
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Article
Open AccessCanagliflozin alleviates pulmonary hypertension by activating PPARγ and inhibiting its S225 phosphorylation
Pulmonary hypertension (PH) is a progressive fatal disease with no cure. Canagliflozin (CANA), a novel medication for diabetes, has been found to have remarkable cardiovascular benefits. However, few studies h...
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Article
Acoustic emission characteristics in tensile-shear failure of non-persistent jointed rocks with different undulation angles
Tensile-shear failure commonly occurs during the construction of deep in-situ tunnels. In this paper, direct tensile-shear tests were conducted on rock-like specimens containing regular serrated joints using a...
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Article
Right ventricular dyssynchrony for the prediction of prognosis in patients with systemic lupus erythematosus-aaociated pulmonary arterial hypertension: a study with two-dimensional speckle tracking
Pulmonary arterial hypertension (PAH) is a common complication of systemic lupus erythematosus (SLE), and PAH can cause right ventricle (RV) remodel and dyssynchrony. The aim of this study was to explore the v...
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Article
Experimental and computational study on the factors affecting the structure of L-proline-catalyzed Knoevenagel condensation
The Knoevenagel condensation of aromatic aldehydes and ethyl acetoacetate catalyzed by L-proline in water, ionic liquid, and deep eutectic solvents (DESs), respectively, was studied. The mild reaction conditio...
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Article
MRI-detected tumor deposits in cT3 and cT4 rectal cancer following neoadjuvant chemoradiotherapy
To evaluate the identification of tumor deposits (TDs) and the prognostic significance of an MRI tumor regression grade for TDs in patients with rectal cancer treated with neoadjuvant chemoradiotherapy (nCRT).
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Article
Open AccessNasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1
Develo** a mucosal vaccine against SARS-CoV-2 is critical for combatting the epidemic. Here, we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a t...
