25 Result(s)
within
**ao-Jun Qin
Life Sciences
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Article
Open AccessLysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance
Posttranslational modification dramatically enhances protein complexity, but the function and precise mechanism of novel lysine acylation modifications remain unknown. Chemoresistance remains a daunting challe...
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Open AccessSucrose metabolism analysis in a high sucrose sugarcane mutant clone at a mature stage in contrast to low sucrose parental clone through the transcriptomic approach
The significance of sugarcane as a major crop is due to the production of sucrose and a significant source of ethanol. Sucrose phosphate synthase (SPS), Sucrose synthase (SuSy), and cell wall invertase (CWIN) ...
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Open AccessComparative genome anatomy reveals evolutionary insights into a unique amphitriploid fish
Triploids are rare in nature because of difficulties in meiotic and gametogenic processes, especially in vertebrates. The Carassius complex of cyprinid teleosts contains sexual tetraploid crucian carp/goldfish (C...
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Proteome Based Comparative Investigation of a High Sucrose Sugarcane Mutant in Contrast to the Low Sucrose Mother Variety by Using TMT Quantitative Proteomics
Sugarcane (Saccharum sp. hybrid) is a significant crop in the world’s economy and fulfills 80% of the world's sugar production. To meet the rising sugar requirement, it is emphasized to enhance the cane sugar yie...
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Open AccessNotch3 inhibits cell proliferation and tumorigenesis and predicts better prognosis in breast cancer through transactivating PTEN
Notch receptors (Notch1–4) play critical roles in tumorigenesis and metastasis of malignant tumors, including breast cancer. Although abnormal Notch activation is related to various tumors, the importance of s...
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Open AccessSingle-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with extremely skewed ethnic and geographic distributions. Increasing evidence indicates that targeting the tumor microenvironment (TME) represents a ...
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Metabolomics profiling reveals the mechanism of increased pneumocandin B0 production by comparing mutant and parent strains
Metabolic profiling was used to discover mechanisms of increased pneumocandin B0 production in a high-yield strain by comparing it with its parent strain. Initially, 79 intracellular metabolites were identified, ...
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Sirtuin-3 (SIRT3) protects pancreatic β-cells from endoplasmic reticulum (ER) stress-induced apoptosis and dysfunction
Insufficient insulin produced by pancreatic β-cells in the control of blood sugar is a central feature of the etiology of diabetes. Reports have shown that endoplasmic reticulum (ER) stress is fundamentally in...
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Article
Cost of agronomic biofortification of wheat with zinc in China
Biofortification is a strategy for overcoming human zinc (Zn) deficiency, especially in rural areas of develo** countries. Actually, biofortification by foliar Zn application has been demonstrated at small s...
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Chronic adjunction of 1-deoxynojirimycin protects from age-related behavioral and biochemical changes in the SAMP8 mice
Several studies have indicated that a caloric restriction mimetic or treatment for type 2 diabetes may reverse brain aging. Therefore, we investigated the effect of 1-deoxynojirimycin (DNJ), an alkaloid acting...
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Open AccessHigh salt primes a specific activation state of macrophages, M(Na)
High salt is positively associated with the risk of many diseases. However, little is known about the mechanisms. Here we showed that high salt increased proinflammatory molecules, while decreased anti-inflamm...
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Map-based cloning of a spotted-leaf mutant gene OsSL5 in Japonica rice
A japonica rice mutant, spotted-leaf 5 (sl5), was identified from YUN32 by EMS mutagenesis. The number of spots in leaves increased from maturity to late maturity in sl5, however, the leaves did not dry and withe...
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Trehalase in Harmonia axyridis (Coleoptera: Coccinellidae): effects on beetle locomotory activity and the correlation with trehalose metabolism under starvation conditions
Trehalose is important in the energy metabolism of insects and protects them from extreme environmental conditions. To study the synthesis and degradation of trehalose, which is hydrolyzed to glucose by trehal...
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Vibrio harveyi as a causative agent of mass mortalities of megalopa in the seed production of swimming crab Portunus trituberculatus
Outbreaks of mass mortalities among cultured megalopa of swimming crab (Portunus trituberculatus) occurred in a commercial hatchery during the spring of 2012 in Jiangsu province, P. R. China. Dominant bacteria we...
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ABC transporters coupled with the elevated ergosterol contents contribute to the azole resistance and amphotericin B susceptibility
Most screening approaches produce compounds that target survival genes and are likely to generate resistance over time. Simply having more drugs does not address the potential emergence of resistance caused by...
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Update analysis of studies on the MMP-9 −1562 C>T polymorphism and cancer risk
Polymorphisms in the matrix metalloproteinase (MMP) gene have been hypothesized to be functional and may contribute to genetic susceptibility to cancers. The common sequence variation in MMP-9 −1562 C>T (rs391...
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Effects of applied urea and straw on various nitrogen fractions in two Chinese paddy soils with differing clay mineralogy
Combined application of synthetic nitrogen (N) fertilizers and organic materials can enhance soil quality, but little is known about the distribution of fertilizer N among different soil fractions after crop h...
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RNASEL −1385G/A polymorphism and cancer risk: a meta-analysis based on 21 case–control studies
Polymorphisms in the endoribonuclease L (RNASEL) gene have been hypothesized to increase the incidence of cancer. The common sequence variation in RNASEL, −1385G/A (rs486907) has been involved in several types...
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Article
Expression patterns of two Arabidopsis endo-β-1,4-glucanase genes (At3g43860, At4g39000) in reproductive development
Endo-β-1,4-D-glucanases (EGases) are a widespread and vital group of glycosyl hydrolases that generally break the β-1,4-glucosyl linkages. Studies of plant EGases have mainly been concentrated on vegetative growt...
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Optimum conditions for pure culture of major ectomycorrhizal fungi obtained from Pinus sylvestris var. mongolica plantations in southeastern Keerqin sandy lands, China
The effects of medium, pH, water potential and temperature on the culture for three pure strains (Lactarius deliciosus, Boletus edulis and Lactarius insulsus) of ectomycorrhizal fungi from plantation forests of M...
