5 Result(s)
within
Neurology
**ao-Fen Wang
-
Article
Open AccessSystemic administration of urocortin after intracerebral hemorrhage reduces neurological deficits and neuroinflammation in rats
Intracerebral hemorrhage (ICH) remains a serious clinical problem lacking effective treatment. Urocortin (UCN), a novel anti-inflammatory neuropeptide, protects injured cardiomyocytes and dopaminergic neurons....
-
Article
Open AccessA rapid and cost-effective method for genoty** apolipoprotein E gene polymorphism
Apolipoprotein E (ApoE) is a major cholesterol carrier and plays an important role in maintaining lipid homeostasis both in the periphery and brain. Human APOE gene is polymorphic at two single nucleotides (rs429...
-
Article
Open AccessLRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways
Neuroinflammation is characterized by microglial activation and the increased levels of cytokines and chemokines in the central nervous system (CNS). Recent evidence has implicated both beneficial and toxic ro...
-
Article
Open AccessAmyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)
TREM2 is an innate immune receptor specifically expressed in microglia. Coding variations in TREM2 have been reported to increase the risk for Alzheimer’s disease (AD) and other neurodegenerative diseases. Whi...
-
Article
Open AccessIdentification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology
TREM2 is a microglial receptor genetically linked to the risk for Alzheimer’s disease (AD). The cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2) have emerged as a valuable biomarker for the disease p...
