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Article
A new tau dephosphorylation-targeting chimera for the treatment of tauopathies
Abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies, including Alzheimer’s disease (AD). We have recently conceptualize...
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Article
Open AccessReduction of precious metal ions in aqueous solutions by contact-electro-catalysis
Precious metals are core assets for the development of modern technologies in various fields. Their scarcity poses the question of their cost, life cycle and reuse. Recently, an emerging catalysis employing co...
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Article
Defect spinel oxides for electrocatalytic reduction reactions
Electrocatalytic reduction reactions play a crucial role in electrochemical energy conversion and storage technology, which are emerging technologies to ameliorate environmental problems. Spinel oxides are wid...
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Article
Effect of alpha-particle irradiation on microwave-sintered actinide-contaminated soil glass waste
To investigate the irradiation resistance of the microwave sintered contaminated soil samples, the samples were irradiated with 0.5 MeV He2+ ions. The property changes of the irradiated samples were investigated....
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Open AccessA contact-electro-catalysis process for producing reactive oxygen species by ball milling of triboelectric materials
Ball milling is a representative mechanochemical strategy that uses the mechanical agitation-induced effects, defects, or extreme conditions to activate substrates. Here, we demonstrate that ball grinding coul...
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Article
Open AccessEfficacy of Qingpeng ointment (a Tibetan medicine) for acute gouty arthritis: a multi-center, randomized, double-blind, placebo-controlled trial
This study aims to assess the efficacy and safety of Qingpeng ointment (QPO), a Tibetan medicine for alleviating symptoms in individuals with acute gouty arthritis (AGA).
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Open AccessThe middle-aged and older Chinese adults’ health using actigraphy in Taiwan (MOCHA-T): protocol for a multidimensional dataset of health and lifestyle
Older adults keep transforming with Baby Boomers and Gen Xers being the leading older population. Their lifestyle, however, is not well understood. The middle-aged and older Chinese adults’ health using actigr...
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Article
Open AccessDoes national culture influence corporate social responsibility on firm performance?
In recent years, the influence of corporate social responsibility (CSR) on firm performance has received increasing attention, with academic research deepening in this field. This study introduces national cul...
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Associations of prenatal exposure to bisphenols with BMI growth trajectories in offspring within the first two years: evidence from a birth cohort study in China
Prenatal bisphenol exposure has been reported to be associated with lower birth weight and obesity-related indicators in early childhood. These findings warrant an investigation of the relationship between pre...
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Article
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation
Diabetic neuropathic pain (DNP) is a common and destructive complication of diabetes mellitus. The discovery of effective therapeutic methods for DNP is vitally imperative because of the lack of effective trea...
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Article
Real-world treatment outcome with protease inhibitor direct-acting antiviral in advanced hepatitis C cirrhosis: a REAL-C study
Current guidelines discourage the use of direct-acting antiviral (DAA) containing protease-inhibitor (PI) in advanced HCV cirrhosis. We aimed to compare the real-world tolerability of PI vs. non-PI DAA regimen...
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Article
Fast Li-ion conduction enabled by graphite fluoride flakes in solid polymer electrolyte
在高能量密度的锂金属电池中，锂金属阳极与液体电解质容易发生副反应的特点将导致电池的容量下降和发生严重的安全问题。固体电解质能有效解决因枝晶生长和液体电解质电化学稳定性不好所带来的安全问题。本文提出将低成本、低重量的氟化石墨片((CFx)n)作为填料与PEO-LiTFSI固体聚合物电解质进行复合的固态电解质。氟化石墨片可提供大量的氟离子与锂盐发生**烈的相互作用，从而增加了的可移动Li+离子的数量，从而提高了复合电解质的总离...
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Article
Assessing the impacts of natural conditions and human activities on terrestrial water storage in Loess Plateau, China
The gravity recovery and climate experiment (GRACE) has emerged as a crucial source of land water storage information in hydrological analysis and research. Numerous factors contribute to regional terrestrial ...
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Article
Graphene quantum dots modulated solution-derived InGaO thin-film transistors and stress stability exploration
Graphene quantum dots (GQDs) doped InGaO (IGO) thin film transistors (TFTs) have been fabricated based on solution-driven ZrOx as gate dielectrics. Compare to pure IGO TFTs, superior electrical performance of the...
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Article
Open AccessImpact of adenomyosis and endometriosis on IVF/ICSI pregnancy outcome in patients undergoing gonadotropin-releasing hormone agonist treatment and frozen embryo transfer
Although numerous studies have attempted to establish the relationship between adenomyosis and infertility, no consensus has emerged. Our aim was to investigate whether adenomyosis and endometriosis affected I...
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Article
Open AccessDeep vein thrombosis in a patient with Cronkhite-Canada syndrome: a complex case report
Cronkhite-Canada syndrome (CCS) is a rare disease characterized by generalized gastrointestinal polyps, ectodermal abnormalities and variable gastrointestinal symptoms. Few cases to date have described complic...
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Article
Open AccessInhibition of phosphorylated calcium/calmodulin-dependent protein kinase IIα relieves streptozotocin-induced diabetic neuropathic pain through regulation of P2X3 receptor in dorsal root ganglia
Diabetic neuropathic pain (DNP) is frequent among patients with diabetes. We previously showed that P2X3 upregulation in dorsal root ganglia (DRG) plays a role in streptozotocin (STZ)-induced DNP but the under...
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Article
Dorsal root ganglia P2X4 and P2X7 receptors contribute to diabetes-induced hyperalgesia and the downregulation of electroacupuncture on P2X4 and P2X7
Diabetic neuropathic pain (DNP) is highly common in diabetes patients. P2X receptors play critical roles in pain sensitization. We previously showed that elevated P2X3 expression in dorsal root ganglion (DRG) ...
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Article
Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor
Upregulation of P2X3 receptor (P2X3R) has been strongly implicated in nociceptive signaling including bone cancer pain (BCP). The present study, using rat bone cancer model, aimed to explore the role of P2X3R ...
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Article
Polymorphisms of haptoglobin modify the relationship between dietary iron and the risk of gestational iron-deficiency anemia
To assess whether polymorphisms of haptoglobin (Hp) modify the relationship between dietary iron and the risk of gestational iron-deficiency anemia (IDA).
