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Article
Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer’s Disease
Neuroinflammation and endothelial cell apoptosis are prominent features of blood–brain barrier (BBB) disruption, which have been described in Alzheimer’s disease (AD) and can predict cognitive decline. Recent ...
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Article
Open AccessAn ultrawide-range photochromic molecular fluorescence emitter
Photocontrollable luminescent molecular switches capable of changing emitting color have been regarded as the ideal integration between intelligent and luminescent materials. A remaining challenge is to combin...
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Article
From Perspective of Hippocampal Plasticity: Function of Antidepressant Chinese Medicine **aoyaosan
The hippocampus is one of the most commonly studied brain regions in the context of depression. The volume of the hippocampus is significantly reduced in patients with depression, which severely disrupts hippo...
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Article
A novel FAK-degrading PROTAC molecule exhibited both anti-tumor activities and efficient MDR reversal effects
FAK (focal adhesion kinase) is widely involved in cancer growth and drug resistance development. Thus, FAK inhibition has emerged as an effective strategy for tumor treatment both as a monotherapy or in combin...
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Article
Open AccessPrevalence and genetic diversity of Anaplasma and Ehrlichia in ticks and domesticated animals in Suizhou County, Hubei Province, China
Anaplasma and Ehrlichia are tick-borne bacterial pathogens that cause anaplasmoses and ehrlichioses in humans and animals. In this study, we examined the prevalence of Anaplasma and Ehrlichia species in ticks and...
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Article
Open AccessHBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis
The root of Aconitum carmichaelii Debx. (Fuzi) is an herbal medicine used in China that exerts significant efficacy in rescuing patients from severe diseases. A key toxic compound in Fuzi, aconitine (AC), could t...
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Article
Open AccessFicolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis
Targeting ferroptosis has been identified as a promising approach for the development of cancer therapies. Monounsaturated fatty acid (MUFA) is a type of lipid that plays a crucial role in inhibiting ferropto...
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Article
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer
The retinoic acid receptor-related orphan receptor γ (RORγ) is regarded as an attractive therapeutic target for the treatment of prostate cancer. Herein, we report the identification, optimization, and evaluat...
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Article
Therapeutic application of circular RNA aptamers in a mouse model of psoriasis
Efforts to advance RNA aptamers as a new therapeutic modality have been limited by their susceptibility to degradation and immunogenicity. In a previous study, we demonstrated synthesized short double-stranded...
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Article
Liver receptor homolog-1: structures, related diseases, and drug discovery
Liver receptor homolog-1 (LRH-1), a member of the nuclear receptor superfamily, is a ligand-regulated transcription factor that plays crucial roles in metabolism, development, and immunity. Despite being class...
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Article
Open AccessLncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1
Considering the effect of SIRT1 on improving myocardial fibrosis and GAS5 inhibiting occurrence and development of myocardial fibrosis at the cellular level, the aim of the present study was to investigate whe...
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Article
Knockout of lws1 in zebrafish (Danio rerio) reveals its role in regulating feeding and vision-guided behavior
Long-wave sensitive (LWS) is a G protein-coupled receptor expressed in the retina, and zebrafish is a better model organism for studying vision, but the role of LWS1 in vision-guided behavior of larvae fish ha...
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Article
Sonocatalytic degradation of tetracycline by BiVO4/CuWO4 nanocomposites: operational parameters, sonocatalytic mechanism, and degradation pathways
In this study, BiVO4/CuWO4 nanocomposites with S-scheme heterojunction structure were prepared firstly and the properties were analyzed by various techniques. The sonocatalytic activity was evaluated by the degra...
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Chapter and Conference Paper
Research and Application of Anti-Emulsification Oil Washing Workover Fluid Technology
In order to solve the reservoir pollution during the workover operation in the complex fault block oilfield of Dagang Oilfield, especially the high pour point oil blocks represented by **aoji and Duanliubao, m...
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Article
Open AccessAdvances in nuclear detection and readout techniques
“A Craftsman Must Sharpen His Tools to Do His Job,” said Confucius. Nuclear detection and readout techniques are the foundation of particle physics, nuclear physics, and particle astrophysics to reveal the nat...
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Article
Open AccessBuilding bridges of excellence: a comprehensive competence framework for nurses in hospice and palliative care—a mixed method study
Hospice and Palliative Care (HPC) is in high demand in China; however, the country is facing the shortage of qualified HPC nurses. A well-suited competence framework is needed to promote HPC human resource dev...
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Article
Persistent activation of peroxymonosulfate by MoS2@FeOOH/ceramsite composite for continuous flow degradation of sulfamethoxazole
Within the realm of wastewater treatment, the restrictions of inter-particle agglomeration and difficulty in recovery of traditional powder materials greatly limited their large-scale application. Hence, a nov...
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Article
Measurement of Br(n,γ) cross sections up to stellar s-process temperatures at the CSNS Back-n
The neutron capture cross sections ( \({n,\gamma }\) n , ...
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Article
Open AccessThe oral bacterial microbiota facilitates the stratification for ulcerative colitis patients with oral ulcers
Clinically, a large part of inflammatory bowel disease (IBD) patients is complicated by oral lesions. Although previous studies proved oral microbial dysbiosis in IBD patients, the bacterial community in the g...
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Article
Two annular CsI(Tl) detector arrays for the charged particle telescopes
In this study, we constructed two annular detector arrays comprising 24 wedge-shaped CsI(Tl) crystals, and tested them using an \(\alpha\) ...
