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Article
Copper-catalyzed enantioselective desymmetrizing C(sp2)–H functionalization of azide-ynamides via α-imino copper carbenes
α-Imino metal carbenes are versatile intermediates in organic synthesis, and have broad applications in the assembly of divergent N-heterocycles. However, the catalytic enantioselective desymmetrization based on
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Article
Atomic-Scale Insights into Damage Mechanisms of GGr15 Bearing Steel Under Cyclic Shear Fatigue
Alternating shear stress is a critical factor in the accumulation of damage during rolling contact fatigue, severely limiting the service life of bearings. However, the specific mechanisms responsible for the ...
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Article
Integrability, bilinearization, Bäcklund transformations and solutions for a generalized variable-coefficient Gardner equation with an external-force term in a fluid or plasma
A generalized variable-coefficient Gardner equation with an external-force term is investigated which can model the propagation and interaction of some nonlinear waves in a fluid or plasma. Via the Hirota bili...
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Article
Open AccessNovel radiopaque ethanol injection: physicochemical properties, animal experiments, and clinical application in vascular malformations
Despite the efficacy of absolute ethanol (EtOH), its radiolucency introduces several risks in interventional therapy for treating vascular malformations. This study aims to develop a novel radiopaque ethanol i...
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Article
Open AccessLandform and lithospheric development contribute to the assembly of mountain floras in China
Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...
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Article
Research on Three-Phase Unbalance Control of Low-Voltage Distribution Network Based on Load Commutation
In order to control the three-phase imbalance problem of low-voltage distribution network, this paper proposes a governance scheme based on the improved whale optimization algorithm (WOA) algorithm to solve th...
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Article
Open AccessAlternative dimethylsulfoniopropionate biosynthesis enzymes in diverse and abundant microorganisms
Dimethylsulfoniopropionate (DMSP) is an abundant marine organosulfur compound with roles in stress protection, chemotaxis, nutrient and sulfur cycling and climate regulation. Here we report the discovery of a ...
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Article
Open AccessThe nuclear and mitochondrial genome assemblies of Tetragonisca angustula (Apidae: Meliponini), a tiny yet remarkable pollinator in the Neotropics
The field of bee genomics has considerably advanced in recent years, however, the most diverse group of honey producers on the planet, the stingless bees, are still largely neglected. In fact, only eleven of t...
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Article
Open AccessMolecular ferroelectric with low-magnetic-field magnetoelectricity at room temperature
Magnetoelectric materials, which encompass coupled magnetic and electric polarizabilities within a single phase, hold great promises for magnetic controlled electronic components or electric-field controlled s...
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Article
Exploration of anomaly separation technology of wide-field electromagnetic method
To improve the accuracy of data processing and interpretation, effective suppression of the regional background field and extraction of the local anomaly field for further analyses represent urgent issues that...
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Article
Mitogen-Activated Protein Kinases Mediate Adventitial Fibroblast Activation and Neointima Formation via GATA4/Cyclin D1 Axis
Activation of mitogen-activated protein kinases (MAPKs) by pathological stimuli participates in cardiovascular diseases. Dysfunction of adventitial fibroblast has emerged as a critical regulator in vascular re...
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Article
Sodium Crotonate Alleviates Diabetic Kidney Disease Partially Via the Histone Crotonylation Pathway
Diabetic kidney disease (DKD) is a common microvascular complication of diabetes, inflammation and fibrosis play an important role in its progression. Histone lysine crotonylation (Kcr) was first identified as...
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Article
Open AccessFunctional and structural dissection of glycosyltransferases underlying the glycodiversity of wolfberry-derived bioactive ingredients lycibarbarspermidines
Lycibarbarspermidines are unusual phenolamide glycosides characterized by a dicaffeoylspermidine core with multiple glycosyl substitutions, and serve as a major class of bioactive ingredients in the wolfberry....
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Article
Fully measurement-device-independent two-way quantum key distribution with finite single-photon sources
Despite the proven security in theory and its potential to achieve high secret key rates, eavesdroppers may crack two-way quantum key distribution (TWQKD) systems by exploiting imperfections of the detection d...
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Article
Open AccessABA-mediated regulation of rice grain quality and seed dormancy via the NF-YB1-SLRL2-bHLH144 Module
Abscisic acid (ABA) plays a crucial role in promoting plant stress resistance and seed dormancy. However, how ABA regulates rice quality remains unclear. This study identifies a key transcription factor SLR1-l...
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Article
Stigma of mental illness among health professions and non-health professions students in China
It is still unclear about the differences of stigma of mental illness and its influencing factors between health profession (HP) and non-health profession (NHP) students in China. This study aimed to explore t...
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Article
PRDX1 Interfering Peptide Disrupts Amino Acids 70–90 of PRDX1 to Inhibit the TLR4/NF-κB Signaling Pathway and Attenuate Neuroinflammation and Ischemic Brain Injury
Ischemic stroke ranks among the leading causes of death and disability in humans and is accompanied by motor and cognitive impairment. However, the precise mechanisms underlying injury after stroke and effecti...
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Article
Open AccessCLK2 mediates IκBα-independent early termination of NF-κB activation by inducing cytoplasmic redistribution and degradation
Activation of the NF-κB pathway is strictly regulated to prevent excessive inflammatory and immune responses. In a well-known negative feedback model, IκBα-dependent NF-κB termination is a delayed response pat...
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Article
Overtop** Failure Process and Core Wall Fracture Mechanism of a New Concrete Core Wall Dam
Concrete core wall dams have emerged as a cost-effective alternative to the reconstruction of old dams. However, the flooding mechanism and flood line of these dams differ significantly from traditional earth ...
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Article
Open AccessClinical characteristics and prognosis of patients with hypertrophic cardiomyopathy and heart failure with preserved ejection fraction
Whether heart failure with preserved ejection fraction (HFpEF) is associated with an increased risk of develo** systolic dysfunction and a poor prognosis in hypertrophic cardiomyopathy (HCM) patients is unkn...
