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Article
Open AccessA Phase 3, Randomized, Controlled Trial Evaluating the Efficacy and Safety of Ropeginterferon Alfa-2b in Patients with Moderate COVID-19
Ropeginterferon alfa-2b is a novel mono-pegylated proline-interferon. This clinical study aimed to evaluate its antiviral efficacy of ropeginterferon alfa-2b against SARS-CoV-2 infection.
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Open AccessSpecific convulsions and brain damage in children hospitalized for Omicron BA.5 infection: an observational study using two cohorts
SARS-CoV-2 continues to mutate over time, and reports on children infected with Omicron BA.5 are limited. We aimed to analyze the specific symptoms of Omicron-infected children and to improve patient care.
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Article
Open AccessComparing transfusion reactions between pre-storage and post-storage leukoreduced apheresis platelets: an analysis using propensity score matching
Transfusion reactions induced by platelet transfusions may be reduced and alleviated by leukocyte reduction of platelets. Although leukoreduction of apheresis platelets can be performed either pre-storage or p...
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Article
Open AccessGene variants and clinical characteristics of children with sitosterolemia
To enhance the detection, management and monitoring of Chinese children afflicted with sitosterolemia by examining the physical characteristics and genetic makeup of pediatric patients.
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Article
Open AccessRelationship between shoulder and elbow range of motion and ultrasonographic structural abnormalities in the elbow of Taiwanese high school baseball players
Ultrasonographic structural abnormalities are regarded as one of the risk factors of elbow injuries. Elbow injuries are commonly associated with decreased shoulder/elbow range of motion (ROM). The purpose of t...
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Open AccessEfficacy of Qingpeng ointment (a Tibetan medicine) for acute gouty arthritis: a multi-center, randomized, double-blind, placebo-controlled trial
This study aims to assess the efficacy and safety of Qingpeng ointment (QPO), a Tibetan medicine for alleviating symptoms in individuals with acute gouty arthritis (AGA).
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Article
Open AccessPrediction of clinically significant prostate cancer through urine metabolomic signatures: A large-scale validated study
Currently, there are no accurate markers for predicting potentially lethal prostate cancer (PC) before biopsy. This study aimed to develop urine tests to predict clinically significant PC (sPC) in men at risk.
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Article
Open AccessURI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers
The clinical benefit of tyrosine kinase inhibitors (TKIs)-based systemic therapy for advanced hepatocellular carcinoma (HCC) is limited due to drug resistance. Here, we uncover that lipid metabolism reprogramm...
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Open AccessInhibition of GSDMD-mediated pyroptosis triggered by Trichinella spiralis intervention contributes to the alleviation of DSS-induced ulcerative colitis in mice
Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is increasing worldwide. Although there is currently no completely curative treatment, helminthic therapy shows cer...
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Open AccessTargeting pathogenic macrophages by the application of SHP-1 agonists reduces inflammation and alleviates pulmonary fibrosis
Idiopathic pulmonary fibrosis is a progressive fibrotic disorder with no cure that is characterized by deterioration of lung function. Current FDA-approved drugs for IPF delay the decline in lung function, but...
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Article
Open AccessMachine learning combined with radiomics and deep learning features extracted from CT images: a novel AI model to distinguish benign from malignant ovarian tumors
To develop an artificial intelligence (AI) model with radiomics and deep learning (DL) features extracted from CT images to distinguish benign from malignant ovarian tumors.
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Article
Open AccessMultimodal ultrasound features of breast cancers: correlation with molecular subtypes
To investigate whether multimodal intratumour and peritumour ultrasound features correlate with specific breast cancer molecular subtypes.
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Article
Open AccessA ring-like accretion structure in M87 connecting its black hole and jet
The nearby radio galaxy M87 is a prime target for studying black hole accretion and jet formation1,2. Event Horizon Telescope observations of M87 in 2017, at a wavelength of 1.3 mm, revealed a ring-like structure...
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Open AccessEvaluation of the immunization effectiveness of bOPV booster immunization and IPV revaccination
To provide a basis for further optimization of the polio sequential immunization schedule, this study evaluated the effectiveness of booster immunization with one dose of bivalent oral poliovirus vaccine (bOPV...
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Article
Open AccessLinalyl Acetate Ameliorates Mechanical Hyperalgesia Through Suppressing Inflammation by TSLP/IL-33 Signaling
Neuropathic pain is a debilitating chronic disorder, significantly causing personal and social burdens, in which activated neuroinflammation is one major contributor. Thymic stromal lymphopoietin (TSLP) and in...
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Article
Open AccessOne-step metallization of weft-knitted fabrics for wearable biaxial strain sensors
One-step direct patterning of high definition conductive tracks in textiles is realized through laser direct writing in combination with a silver organometallic ink developed in-house. Photoreduction, nano-cry...
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Article
Fungal diversity notes 1512–1610: taxonomic and phylogenetic contributions on genera and species of fungal taxa
This article is the 14th in the Fungal Diversity Notes series, wherein we report 98 taxa distributed in two phyla, seven classes, 26 orders and 50 families which are described and illustrated. Taxa in this stu...
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Open AccessA review on chemical precipitation in carbon capture, utilization and storage
Carbon capture, utilization, and storage (CCUS) technologies are being developed to address the increasing CO2 emissions, mitigating the global warming and climate change. In this context, chemical precipitation ...
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Article
Open AccessParticulate matter may have a limited influence on maternal vitamin D levels
Evidence for an association between the amount of particulate matter (PM) in the atmosphere and vitamin D status of pregnant women is limited. We aimed to examine the independent association between PM and mat...
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Article
Open AccessDiagnostic value of apparent diffusion coefficient in predicting pathological T stage in patients with thymic epithelial tumor
This study aimed to evaluate the diagnostic capacity of apparent diffusion coefficient (ADC) in predicting pathological Masaoka and T stages in patients with thymic epithelial tumors (TETs).
