523 Result(s)

Article

DUSP22 inhibits lung tumorigenesis by suppression of EGFR/c-Met signaling

DUSP22, an atypical dual-specificity phosphatase enzyme, plays a significant role in regulating multiple kinase signaling pathways by dephosphorylation. Our study demonstrated that decreased DUSP22 expression ...

Hsiao-Han Lin, Cheng-Wei Chang, Yu-Ting Liao, Shauh-Der Yeh… in Cell Death Discovery (2024)

Article

AGR2-mediated unconventional secretion of 14-3-3ε and α-actinin-4, responsive to ER stress and autophagy, drives chemotaxis in canine mammary tumor cells

Canine mammary tumors (CMTs) in intact female dogs provide a natural model for investigating metastatic human cancers. Our prior research identified elevated expression of Anterior Gradient 2 (AGR2), a protein...

Stephen Hsien-Chi Yuan, Chih-Ching Wu, Yu-Chih Wang… in Cellular & Molecular Biology Letters (2024)

Article

Dysregulated dendritic cells in sepsis: functional impairment and regulated cell death

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Studies have indicated that immune dysfunction plays a central role in the pathogenesis of sepsis. D...

Li-yu Zheng, Yu Duan, Peng-yi He, Meng-yao Wu… in Cellular & Molecular Biology Letters (2024)

Article

Spatial transcriptomics reveals gene interactions and signaling pathway dynamics in rat embryos with anorectal malformation

Anorectal malformation (ARM) is a prevalent early pregnancy digestive tract anomaly. The intricate anatomy of the embryonic cloaca region makes it challenging for traditional high-throughput sequencing methods...

Chen-Yi Wang, Mu-Yu Li, Si-Ying Li, **ao-Gao Wei… in Cell Biology and Toxicology (2024)

Article

Ferroptosis: a potential bridge linking gut microbiota and chronic kidney disease

Ferroptosis is a novel form of lipid peroxidation-driven, iron-dependent programmed cell death. Various metabolic pathways, including those involved in lipid and iron metabolism, contribute to ferroptosis regu...

Zi-Hui Mao, Zhong-**uzi Gao, Shao-Kang Pan, Dong-Wei Liu… in Cell Death Discovery (2024)

Article

FOXP4-mediated induction of PTK7 activates the Wnt/β-catenin pathway and promotes ovarian cancer development

Ovarian cancer (OV) poses a significant challenge in clinical settings due to its difficulty in early diagnosis and treatment resistance. FOXP4, belonging to the FOXP subfamily, plays a pivotal role in various...

**g Ji, Qilan Qian, Wenhao Cheng, **aoqing Ye, Aixin **g… in Cell Death & Disease (2024)

Article

NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis

Members of the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing (NLRP) family regulate various physiological and pathological processes. However, none have been shown ...

Li-Ya Shi, Yang Wang, Yan-Jie Yang, Qian Li… in Cellular & Molecular Biology Letters (2024)

Article

USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy

Drug resistance in cancer therapy is the major reason for poor prognosis. Addressing this clinically unmet issue is important and urgent. In this study, we found that targeting USP24 by the specific USP24 inhi...

Ming-Jer Young, Shao-An Wang, Yung-Ching Chen, Chia-Yu Liu… in Cell Death & Differentiation (2024)

Article

Arsenic trioxide augments immunogenic cell death and induces cGAS-STING-IFN pathway activation in hepatocellular carcinoma

The treatment of hepatocellular carcinoma (HCC) is particularly challenging due to the inherent tumoral heterogeneity and easy resistance towards chemotherapy and immunotherapy. Arsenic trioxide (ATO) has emer...

**n Li, Yu-Fei Pan, Yi-Bin Chen, Qian-Qian Wan, Yun-Kai Lin… in Cell Death & Disease (2024)

Article

Retraction Note: Forkhead factor FOXQ1 promotes TGF-β1 expression and induces epithelial–mesenchymal transition

Dong-Mei Fan, **ao-Shan Feng, Peng-Wei Qi… in Molecular and Cellular Biochemistry (2024)

Article

OTUB1/NDUFS2 axis promotes pancreatic tumorigenesis through protecting against mitochondrial cell death

Pancreatic cancer is one of the most fatal cancers in the world. A growing number of studies have begun to demonstrate that mitochondria play a key role in tumorigenesis. Our previous study reveals that NDUFS2 (N...

**ao-Dong Huang, Li Du, **ao-Chen Cheng, Yu-**n Lu, Qiao-Wei Liu… in Cell Death Discovery (2024)

Article

Role of RB1 in neurodegenerative diseases: inhibition of post-mitotic neuronal apoptosis via Kmt5b

During the development of the vertebrate nervous system, 50% of the nerve cells undergo apoptosis shortly after formation. This process is important for sculpting tissue during morphogenesis and removing trans...

Shuang Zhao, Guiling Mo, Qiang Wang, ** Xu, Shihui Yu… in Cell Death Discovery (2024)

Article

The requirement of the mitochondrial protein NDUFS8 for angiogenesis

Mitochondria are important for the activation of endothelial cells and the process of angiogenesis. NDUFS8 (NADH:ubiquinone oxidoreductase core subunit S8) is a protein that plays a critical role in the functi...

Qian-wei **ong, Kun Jiang, **ao-wei Shen, Zhou-rui Ma… in Cell Death & Disease (2024)

Article

RIPK1 inhibitor ameliorates pulmonary injury by modulating the function of neutrophils and vascular endothelial cells

Acute lung injury (ALI) is an acute and progressive hypoxic respiratory failure that could progress to acute respiratory distress syndrome (ARDS) with a high mortality rate, thus immediate medical attention an...

Tao Yang, Cai-gui **ang, **ao-han Wang, Qing-qing Li, Shu-yue Lei… in Cell Death Discovery (2024)

Article

Correction: LncRNA SNHG1 and RNA binding protein hnRNPL form a complex and coregulate CDH1 to boost the growth and metastasis of prostate cancer

**ao Tan, Wen-bin Chen, Dao-jun Lv, Tao-wei Yang, Kai-hui Wu… in Cell Death & Disease (2024)