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581 Result(s)
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Chapter and Conference Paper
Evaluation of E-Cadherins in Growth Patterns of Gastric Cancer and Its Degree of Cell Differentiation
The growth pattern in gastric cancer (GC) classified into expanding and infiltrative type proposed by professor Ming. This study examined the expression of E-Cadherins (E-Cad), an intercellular adhesion molecu...
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Chapter and Conference Paper
MMC-CH40 Staining the Regional Lymphnodes in the Use of Radical Operation for Gastric Cancer
In the present study, 1-2 ml MMC-CH40 have been injected directly into the lymphnodes (LNs) around the cancer during the operation, LN clearing number (23±11 LNs/case) was 1.13 times higher after the injection co...
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Article
mRNA levels of nm23 in murine ascites hepatoma (H22) clones with different lymphatic metastatic potential
Levels of expression of the nm23 gene inversely correlated with metastatic potential in several rodent tumor model systems and human breast carcinoma. In the present study, we examined nm23 mRNA levels in two ...
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Article
Elevated activity of N -acetylglucosaminyltransferase V in human hepatocellular carcinoma
Cell-surface glycoproteins are regarded as candidates for involvement in the spread of tumor cells. N-linked β1-6 branched oligosaccharides may contribute directly to the malignant or metastatic phenotypes of...
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Article
Human papillomavirus,Chlamydia trachomatis, and other risk factors associated with cervical cancer in China
High prevalences of human papillomavirus (HPV) andChlamydia trachomatis infections, and their association with cervical cancer, have been reported in some parts of China. Other factors, including pregnancy and sm...
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Article
Evaluation of in vitro chemosensitivity of antitumor drugs using the MTT assay in fresh human breast cancer
Practical criteria were developed in this paper for the purpose of evaluating chemosensitivity of fresh human breast cancer by the MTT assay. The survival rates at maximum inhibition (Imax %) and the concentra...
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Article
Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis
To develop an in vivo model for studying the role of the p53 tumor suppressor in skin carcinogenesis, a murine p53172H mutant (equivalent to human p53175H) was expressed in the epidermis of transgenic mice, utili...
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Article
Predictive chemotherapy of advanced breast cancer directed by MTT assay in vitro
In order to investigate the predictive value of in vitro MTT assay for directing chemotherapy of breast cancer patients, from 1992 to 1995, 156 advanced breast cancer patients who had evaluable lesions were re...
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Chapter
Polyunsaturated Fatty Acids and Their Role in Cancer Invasion and Metastasis
Highly unsaturated fatty acids (HUFAs) have been demonstrated to have anticancer functions in the past decade. Recently, these fatty acids have been shown to exert a regulatory action on tumour cell motility, ...
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Article
Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer
We previously demonstrated that AKT2, a member of protein kinase B family, is activated by a number of growth factors via Ras and PI 3-kinase signaling pathways. Here, we report the frequent activation of AKT2...
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Article
Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties
Abnormalities in cellular differentiation are frequent occurrences in human cancers. Treatment of human melanoma cells with recombinant fibroblast interferon (IFN-β) and the protein kinase C activator mezerein...
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Article
Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-κB activation in gastric cancer cells
Triptolide, a major component in the extract of Chinese herbal plant Tripterygium wilfordii Hook f (TWHf), has potential anti-neoplastic effect. In the present study we investigated the potential therapeutic e...
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Article
Novel target for induction of apoptosis by cyclo-oxygenase-2 inhibitor SC-236 through a protein kinase C-β1-dependent pathway
Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of gastrointestinal cancers. Recently, a similar protective effect has been demonstrated by the specific cyclo-oxygenase-2 (COX-2) inhibitors. Howe...
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Article
Comparison between radioimmunotherapy and external beam radiation therapy for patients with hepatocellular carcinoma
It has previously been observed in animal studies that, at equivalent doses, radioimmunotherapy (RIT) is 2.5 times more effective than multiple fractions of external beam radiation therapy (EBRT) in inhibitin...
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Article
Profiling genes differentially expressed in NGX6 overexpressed nasopharyngeal carcinoma cells by cDNA array
Abstract
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Article
Open AccessRARRES3 expression positively correlated to tumour differentiation in tissues of colorectal adenocarcinoma
RARRES3 is a retinoid-inducible class II tumour-suppressor gene. This study analysed the expression of RARRES3 protein in normal, adenoma and carcinoma tissues of the colorectum and its correlation with tumour di...
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Article
Antisense Tcf inhibits the neoplastic growth of liver cancer cells
T cell transcription factors are nuclear effectors of the Wnt signaling transduction pathway and play crucial roles in embryonic and malignant development. Our previous study showed increased expression level...
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Article
Sensitization of multiple myeloma and B lymphoma lines to dexamethasone and γ-radiation-induced apoptosis by CD40 activation
We examined the effects of CD40 activation with dexamethasone (Dex) or 60Co-γ-irradiation on the growth of malignant B cells in vitro, using the human multiple myeloma (MM) cell line, XG2, and the B lymphoma Daud...
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Article
Association between clinical characteristics and expression abundance of RTKN gene in human bladder carcinoma tissues from Chinese patients
Bladder carcinoma is the most common urological malignancy in China. Gene mutation may be one of causes of carcinogenesis in the cancer. We therefore investigated the mRNA expression of RTKN gene in clinic malign...
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Article
Clinical analysis of microdebrider removal of recurrent respiratory papilloma: A report of 33 cases
OBJECTIVE To investigate the advantages of applying microdebrider removal of juvenile-onset recurrent respiratory papillary epithelioma (JO-RRP), using an endoscopy-assisted prop-up laryngoscope.