375 Result(s)
within
Neurosciences
**ao-**a Jiang
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Article
Excessive iron accumulation in the brain: A possible potential risk of neurodegeneration in Parkinson's disease
In this study a chronic cerebral iron-loaded model was established by feeding mice with high iron diet. Data indicated that brain iron concentrations were significantly increased in iron-fed mice compared with...
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Article
The early cellular pathology of Huntington’s disease
Huntington’s disease (HD) is an inherited neurodegenerative disorder that affects about one in 10,000 individuals in North America. The genetic defect responsible for the disease is an expansion of a CAG repea...
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Chapter
Synthetic studies of farnesyl protein transferase inhibitor pepticinnamin E
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Article
Preliminary study of the behavioral effects of LBS-neuron implantation on seizure susceptibility following middle cerebral artery occlusion in the rat
Neural transplantation is a promising treatment strategy that can restore the motor, sensory and cognitive functions in the rat middle cerebral artery occlusion (MCAO) model of stroke. In particular, neuronal ...
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Chapter
Construction and expression of a recombinant antibody targeted plasminogen activator
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Chapter
Purification and characterization of a new conotoxin from the venom of Conus betulinus
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Chapter
Two-step selective formation of three disulfide bridges in the synthesis of δ-Gonotoxin PVIA
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Protocol
In Vitro Expression Systems for the Huntington Protein
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder resulting from expansion (>37 units) of a polyglutamine tract in huntingtin, a 350 kDa protein of unknown function (1). The N-terminal...
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Article
Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injury
Inactivation of the adenosine A2A receptor (A2AR) consistently protects against ischemic brain injury and other neural insults, but the relative contribution of A2ARs on peripheral inflammatory cells versus A2ARs...
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Article
Time Dependent Effects of 6-OHDA Lesions on Iron Level and Neuronal Loss in Rat Nigrostriatal System
The early changes in iron level and neuronal loss in rat nigrostriatal system were investigated using 6-hydroxydopamine (6-OHDA) unilaterally lesioned rats. The results showed that: 1, 3, 5, 7, and 14 days of ...
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Chapter
Polyglutamine Diseases
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Article
Expression and localization of p80 interleukin-1 receptor protein in the rat spinal cord
The biological effects of interleukin (IL)-1 are mediated by two distinct receptors, the p80 or type I (IL-1RI) and p68 or type II (IL-1RII) receptors. Because IL-1RII has a short, 29-amino acid cytoplasmic do...
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Article
Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse
The widespread distribution of the tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) in the adult brain1 suggests its role in a broad range of brain functions. Here we show evidence ...
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Article
Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior
The hypothalamus responds to circulating leptin and insulin in the control of food intake and body weight. A number of neurotransmitters in the hypothalamus, including γ-aminobutyric acid (GABA), also have key...
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Article
Homing and differentiation of mesenchymal stem cells delivered intravenously to ischemic myocardium in vivo: a time-series study
Mesenchymal stem cells (MSCs) are potential sources of cells for tissue repair. However, little information is available about the time course of homing and differentiation of systemically delivered MSCs after...
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Article
AICAR inhibits the Na+/H+ exchanger in rat hearts—possible contribution to cardioprotection
AICAR (5-amino-1-β-d-ribofuranosyl-imidazole-4-carboxamide) is an adenosine analog which improves the recovery of the heart after ischemia. In some tissues AICAR enters cells and stimulates AMP-activated protein ...
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Article
Open AccessMultiple pathways contribute to the pathogenesis of Huntington disease
Huntington disease (HD) is caused by expansion of a polyglutamine (polyQ) domain in the protein known as huntingtin (htt), and the disease is characterized by selective neurodegeneration. Expansion of the poly...
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Article
Open AccessRecent advances in basic neurosciences and brain disease: from synapses to behavior
Understanding basic neuronal mechanisms hold the hope for future treatment of brain disease. The 1st international conference on synapse, memory, drug addiction and pain was held in beautiful downtown Toronto,...
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Article
Open AccessPathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease
A critical issue in understanding Huntington's disease (HD) pathogenesis is how the ubiquitously expressed mutant huntingtin (mhtt) with an expanded polyglutamine repeat can cause selective toxicity of striata...
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Article
Open AccessMPP+-induced cytotoxicity in neuroblastoma cells: Antagonism and reversal by guanosine
Guanosine exerts neuroprotective effects in the central nervous system. Apoptosis, a morphological form of programmed cell death, is implicated in the pathophysiology of Parkinson’s disease (PD). MPP+, a dopamine...
