18 Result(s)
within
**ao-**a Jiang
Chemistry/Food Science, general
Physical Chemistry
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Article
Spatiotemporal and global profiling of DNA–protein interactions enables discovery of low-affinity transcription factors
Precise dissection of DNA–protein interactions is essential for elucidating the recognition basis, dynamics and gene regulation mechanism. However, global profiling of weak and dynamic DNA–protein interactions...
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Article
Mechanism-based ligand design for copper-catalysed enantioconvergent C(sp3)–C(sp) cross-coupling of tertiary electrophiles with alkynes
In contrast with the well-established enantioconvergent radical C(sp3)–C cross-coupling of racemic secondary alkyl electrophiles, the corresponding coupling of tertiary electrophiles to forge all-carbon quaternar...
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Article
A directive Ni catalyst overrides conventional site selectivity in pyridine C–H alkenylation
Achieving the transition metal-catalysed pyridine C3−H alkenylation, with pyridine as the limiting reagent, has remained a long-standing challenge. Previously, we disclosed that the use of strong coordinating ...
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Article
A general asymmetric copper-catalysed Sonogashira C(sp3)–C(sp) coupling
Continued development of the Sonogashira coupling has made it a well established and versatile reaction for the straightforward formation of C–C bonds, forging the carbon skeletons of broadly useful functional...
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Article
Synthesis, crystal structure, redox property, and cytotoxic activity of a dinuclear cobalt(II) complex bearing a tetradentate benzimidazole ligand
A tetradentate benzimidazole ligand cis,cis,cis,cis-2,2′,2″,2‴-(cyclopentane-1,2,3,4-tetrayl)tetrakis(1H-benzo[d]imidazole) (cttb) and its dinuclear cobalt(II) complex [Co2(cttb)Cl4]·2DMF·H2O have been synthesize...
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Article
Theoretical study about effects of H2O and Na+ on adsorption of CO2 on kaolinite surfaces
The density functional theory(DFT) was used to investigate the adsorptions of carbon dioxide(CO2) on kaolinite surfaces and the influences of Na+ and H2O on the adsorption. Both cluster and periodic models of kao...
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Article
Synthesis and characterization of TS-1 with the aid of supercritical CO2
A new route to synthesize TS-1 has been developed using the supercritical carbon dioxide(SCCO2) as a crystallization-assistant agent. SCCO2 plays a dual role: as a reagent changing the alkalinity during the cryst...
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Article
Antitumor compound identification from Zanthoxylum bungeanum essential oil based on composition-activity relationship
The chemical composition of Zanthoxylum bungeanum(Z. bungeanum) essential oil(39 batches) was analyzed by gas chromatography-mass spectrometry(GC-MS) analysis(23 ingredients), and the antitumor activity against H...
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Article
Design, synthesis and antitumor activity in vitro of a series of 3-arylcoumarins
A new series of 7-substituted 3-arylcoumarins was designed, synthesized and evaluated as novel antitumor agents in vitro. It was found that several compounds of them exhibit activity in vitro against SK-HEP-1(hep...
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Article
Design, synthesis and antitumor activity of a novel series of PAC-1 analogues
A novel series of first procaspase activating compound(PAC-1) analogues was designed, synthesized and evaluated for antitumor activity towards two cell lines[human promyelocytic leukemia cell line(HL60) and hu...
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Article
Phytoestrogens inhibiting androgen receptor signal and prostate cancer cell proliferation
The androgen receptor(AR) signaling activated by dihydrotestosterone(DHT) plays critical roles in prostate cancer development and progression. Phytoestrogens, which are diphenolic compounds with estrogen and a...
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Article
Novel PLGA microspheres for sustained delivery of antisense oligonucleotide
Novel poly(lactide-co-glycolide acid)(PLGA) microspheres were developed for sustained delivery of antisense oligonucleotide(ASO). First, a new cationic agent, polyethylenimine(PEI) conjugated to linoleic acid(...
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Article
Purification and characterization of a novel tetradecapeptide from ginseng polypeptides with enhancing memory activity for mice
Aiming at isolating and investigating the active ingredients of the aqueous extract from Panax ginseng which showed enhancing memory activity, the authors characterized one ingredient. To separate the oligosaccha...
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Article
Determination of amino acids in Panax notoginseng by microwave hydrolysis and derivatization coupled with capillary zone electrophoresis detection
The microwave hydrolysis and derivatization coupled with capillary electrophoresis detection were developed for the separation and determination of the amino acids in Panax notoginseng. The experimental condition...
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Article
Xeno-oestrogens bisphenol a and diethylstilbestrol selectively activating androgen receptor mediated AREs-TATA reporter system
We cloned the three androgen response elements(AREs, including AREI, AREII, and AREIII) with a core transactivation TATA element of the prostate-specific antigen(PSA) promoter into pGL2 basic vector to create an ...
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Article
A QICAR model for metal ion toxicity established via PLS method
The partial least squares(PLS) method was employed to establish a quantitative ion characteristics-activity relationship(QICAR) model for metal ion toxicity(EC50 of 15 metal ions). The ion characteristics include...
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Article
Effects of combinatorial expression of selA, selB and selC genes on the efficiency of selenocysteine incorporation in Escherichia coli
In Escherichia coli, four gene products(selA, selB, selC and selD) and a selenocysteine(Sec) insertion sequence( SECIS) are required for the correct translation of UGA codons encoding Sec. Previous studies have s...
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Article
Chlorofullerenes featuring triple sequentially fused pentagons
The triple sequentially fused pentagons (TSFP) motif is one of the basic subunits that could be used for constructing fullerenes, but it violates the isolated pentagon rule (IPR) and has not been found in carb...
