34 Result(s)
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Article
Open AccessVisual function loss in fungal sphenoid sinusitis: clinical characteristics and outcomes
Potentially fatal fungal sphenoid sinusitis (FSS) causes visual damage. However, few studies have reported on its visual impairment and prognosis. Five hundred and eleven FSS patients with ocular complications...
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Article
Open AccessNardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of various apoptotic pathways. Here, we find that development of ap...
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Open AccessPhosphonate-based iron complex for a cost-effective and long cycling aqueous iron redox flow battery
A promising metal-organic complex, iron (Fe)-NTMPA2, consisting of Fe(III) chloride and nitrilotri-(methylphosphonic acid) (NTMPA), is designed for use in aqueous iron redox flow batteries. A full-cell testing, w...
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Open AccessA study on the impact of marital status on the survival status of prostate cancer patients based on propensity score matching
Marital status is an independent prognostic factor for survival in many types of cancers, but its prognostic impact on patients with prostate cancer (PCa) has not been established. The aim of this study was to...
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Open AccessPrognostic visualization model for primary pulmonary sarcoma: a SEER-based study
Primary pulmonary sarcoma (PPS) is a rare and poor prognostic malignancy that results from current clinical studies are lacking. Our study aimed to investigate the prognostic factors of PPS and to construct a ...
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Open AccessAdherence to pancreatic enzyme replacement therapy among patients with chronic pancreatitis in East China: a mixed methods study
Pancreatic enzyme replacement therapy (PERT) has been recommended as the preferred method for pancreatic exocrine insufficiency caused by chronic pancreatitis (CP). However, at present, the patient-related fac...
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Open AccessTNFα induced by DNA-sensing in macrophage compromises retinal pigment epithelial (RPE) barrier function
Increasing evidence suggests that chronic inflammation plays an important role in the pathogenesis of age-related macular degeneration (AMD); however, the precise pathogenic stressors and sensors, and their im...
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Open AccessDevelopment and validation of a simple-to-use nomogram for self-screening the risk of dyslipidemia
This study aimed to help healthy adults achieve self-screening by analyzing the quantitative relationship between body composition index measurements (BMI, waist-to-hip ratio, etc.) and dyslipidemia and establ...
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Article
Open AccessPlatelet to lymphocyte ratio was a risk factor in Perthes disease
The study was aimed to determine the relationship between PLR (platelet to lymphocyte ratio) and the lateral pillar classification of Perthes disease, and to provide an alternative index for clinical diagnosis...
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Open AccessSite- and enantioselective cross-coupling of saturated N-heterocycles with carboxylic acids by cooperative Ni/photoredox catalysis
Site- and enantioselective cross-coupling of saturated N-heterocycles and carboxylic acids—two of the most abundant and versatile functionalities—to form pharmaceutically relevant α-acylated amine derivatives rem...
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Article
Open AccessThree-dimensional unsupervised probabilistic pose reconstruction (3D-UPPER) for freely moving animals
A key step in understanding animal behaviour relies in the ability to quantify poses and movements. Methods to track body landmarks in 2D have made great progress over the last few years but accurate 3D recons...
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Open AccessProsociality moderates outcome evaluation in competition tasks
The current study investigated the effect of prosociality on outcome evaluation without involving social comparison and reward processing in face-to-face competition tasks. The results showed that when faced w...
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Article
Open AccessInfluence of ulnar bow sign on surgical treatment of missed Bado type I Monteggia fracture in children
The present study aimed to explore the influence of ulnar bow on the surgical treatment of Bado type I missed Monteggia fracture in children. A retrospective review of 28 patients was conducted between Novembe...
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Article
Open AccessA proteogenomic signature of age-related macular degeneration in blood
Age-related macular degeneration (AMD) is one of the most common causes of visual impairment in the elderly, with a complex and still poorly understood etiology. Whole-genome association studies have discovere...
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Article
Open AccessThe regulatory mechanism of LncRNA-mediated ceRNA network in osteosarcoma
Aberrantly expressed lncRNAs have been reported to be closely related to the oncogenesis and development of osteosarcoma. However, the role of a dysregulated lncRNA-miRNA-mRNA network in osteosarcoma in the sa...
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Open AccessA simple prediction model of hyperuricemia for use in a rural setting
Currently, the most widely used screening methods for hyperuricemia (HUA) involves invasive laboratory tests, which are lacking in many rural hospitals in China. This study explored the use of non-invasive phy...
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Open AccessBiosafety assessment of Acinetobacter strains isolated from the Three Gorges Reservoir region in nematode Caenorhabditis elegans
Acinetobacter has been frequently detected in backwater areas of the Three Gorges Reservoir (TGR) region. We here employed Caenorhabditis elegans to perform biosafety assessment of Acinetobacter strains isolated ...
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Open AccessRetroversion of the hemipelvis rather than hypoplastic posterior wall decreases acetabular anteversion in hips affected by Perthes disease
The acetabular retroversion has a moderate incidence of 31–60% in all patients of the Perthes disease. It might be caused by posterior wall dysplasia based on recent animal researches. However, some studies su...
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Article
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer
Despite its success in achieving the long-term survival of 10–30% of treated individuals, immune therapy is still ineffective for most patients with cancer1,2. Many efforts are therefore underway to identify new ...
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Article
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood1–3. Here, to identify a phenotypically robust core set of genes and pathways that enable cancer...
