39 Result(s)
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**ao Mei Wu
Oncology
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Article
Open AccessCorrection: Overexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer
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Article
Open AccessOverexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer
This study aimed to explore the expression, molecular mechanism and its biological function of potassium two pore domain channel subfamily K member 1 (KCNK1) in bladder cancer (BC).
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Article
Open AccessOverexpression of SYNGAP1 suppresses the proliferation of rectal adenocarcinoma via Wnt/β-Catenin signaling pathway
Rectal adenocarcinoma (READ) is a common malignant tumor of the digestive tract. Growing studies have confirmed Ras GTPase-activating proteins are involved in the progression of several tumors. This study aime...
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Article
Automated identification and quantification of metastatic brain tumors and perilesional edema based on a deep learning neural network
This paper presents a deep learning model for use in the automated segmentation of metastatic brain tumors and associated perilesional edema.
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Article
Treatment and survival of patients with small cell lung cancer and brain metastasis
To elucidate treatment patterns and their outcomes in patients with small cell lung cancer (SCLC) and brain metastasis (BM).
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Is it advisable to perform radiosurgery for EGFR-TKI-controlled brain metastases? A retrospective study of the role of radiosurgery in lung cancer treatment
Given the availability of TKIs with high central nervous system efficacy, the question arises as to whether upfront SRS provides additional clinical benefits. The goal of this study was to characterize the cli...
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Improved survival and intracranial tumor control of EGFR-mutated NSCLC patients with newly developed brain metastases following stereotactic radiosurgery and EGFR-TKI: a large retrospective cohort study and meta-analyses
To examine the differential effects of SRS and TKI on EGFR-mutated NSCLC patients with brain metastases (BMs) and outcomes following continuation of the same TKI agent in case of new BMs.
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Article
PDGF-BB/PDGFRβ induces tumour angiogenesis via enhancing PKM2 mediated by the PI3K/AKT pathway in Wilms’ tumour
Platelet-derived growth factor receptor-β (PDGFRβ) is a critical type III receptor tyrosine kinase family member, which is involved in Wilms’ tumour (WT) metastasis and aerobic glycolysis. The role of PDGFRβ i...
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Article
Open AccessAnalysis of Whole Blood and Urine Trace Elements in Children with Autism Spectrum Disorders and Autistic Behaviors
The relationship between trace elements and neurological development is an emerging research focus. We performed a case–control study to explore (1) the differences of 13 trace elements chromium (Cr), manganes...
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Article
Stereotactic radiosurgery for pituitary and cavernous sinus metastases
Metastases extending to the pituitary gland and cavernous sinus are extremely rare; however, advances in neuroimaging have increased the reported incidence. Stereotactic radiosurgery (SRS) affords the precise ...
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Article
Magnetic resonance imaging signal characteristics associated with prognosis of skull base chordoma after gamma knife radiosurgery
To investigate the association between the magnetic resonance imaging (MRI) signal characteristics of skull base chordoma and radiosurgical outcomes.
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Article
Natural history of lung squamous cell brain metastases in patients treated with radiosurgery: a thirty-year experience at a tertiary medical center
In this study we report our 30-year experience in stereotactic radiosurgery (SRS) treatment of lung squamous cell carcinoma (LUSC) brain metastases (BMs). It will serve to provide detailed longitudinal outcome...
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Leukoencephalopathy in patients with brain metastases who received radiosurgery with or without whole brain radiotherapy
Whole brain radiation therapy (WBRT) for brain metastases (BMs) is a common cause of radiation-induced leukoencephalopathy; however the safety of alternative stereotactic radiosurgery (SRS) remains unclear. Th...
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EGFR mutant status and tyrosine-kinase inhibitors affect the GKRS outcomes for NSCLC brain metastases
Tyrosine kinase inhibitors (TKIs) is the first-line treatment for EGFR-positive non-small cell lung cancer (NSCLC); however, its applicability to patients with wild-type NSCLC remains an issue of contention. T...
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Article
Open AccessRole of APOA1 in the resistance to platinum-based chemotherapy in squamous cervical cancer
To investigate the mechanism by which apolipoprotein A1 (APOA1) enhances the resistance of cervical squamous carcinoma to platinum-based chemotherapy.
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Open AccessRetraction Note: Down-regulated lncRNA DLX6-AS1 inhibits tumorigenesis through STAT3 signaling pathway by suppressing CADM1 promoter methylation in liver cancer stem cells
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-019-1239-3.
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Article
Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway
The enhanced release of inflammatory cytokines mediated by high mobility group box1 (HMGB1) leads to pain sensation, and has been implicated in the etiology of inflammatory pain. Paeonol (PAE), a major active ...
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Article
Open AccessCorrection to: microRNA-124 inhibits bone metastasis of breast cancer by repressing Interleukin-11
An amendment to this paper has been published and can be accessed via the original article.
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Article
Repeated gamma knife radiosurgery enables longer tumor control in cases of highly-recurrent intracranial ependymoma
Stereotactic radiosurgery (SRS) is a potential re-irradiation treatment for recurrent intracranial ependymoma after prior radiation therapy. The purpose of this study was to examine the efficacy and safety of ...
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Open AccessNovel role of PAF1 in attenuating radiosensitivity in cervical cancer by inhibiting IER5 transcription
Radiosensitivity is limited in cervical cancer (CC) patients due to acquired radiation resistance. In our previous studies, we found that immediate-early response 5 (IER5) is upregulated in CC cells upon radia...
