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  1. Article

    Open Access

    Endothelial glycocalyx damage in kidney disease correlates with uraemic toxins and endothelial dysfunction

    Damage to the endothelial glycocalyx is an early indicator of vascular damage and a potential marker of endothelial dysfunction. This study aimed to assess the relationship between markers of glycocalyx damage...

    Hui Liew, Matthew A. Roberts, Alun Pope, Lawrence P. McMahon in BMC Nephrology (2021)

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    Article

    Diclofenac sex-divergent drug-drug interaction with Sunitinib: pharmacokinetics and tissue distribution in male and female mice

    Coadministration of diclofenac and sunitinib, tyrosine kinase inhibitor, led to sex-divergent pharmacokinetic drug-drug interaction outcomes. Male and female mice were administered 60 mg/kg PO sunitinib alone ...

    Chii Chii Chew, Salby Ng, Yun Lee Chee, Teng Wai Koo… in Investigational New Drugs (2017)

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    Article

    Sunitinib-paracetamol sex-divergent pharmacokinetics and tissue distribution drug-drug interaction in mice

    The sex-divergent pharmacokinetics and interaction of tyrosine kinase inhibitor sunitinib with paracetamol was evaluated in male and female mice. Mice (control groups) were administered 60 mg/kg PO sunitinib a...

    Ming Hui Liew, Salby Ng, Chii Chii Chew, Teng Wai Koo… in Investigational New Drugs (2017)