![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
1,350 Result(s)
-
Article
Open AccessRNF213 promotes Treg cell differentiation by facilitating K63-linked ubiquitination and nuclear translocation of FOXO1
Autoreactive CD4+ T helper cells are critical players that orchestrate the immune response both in multiple sclerosis (MS) and in other neuroinflammatory autoimmune diseases. Ubiquitination is a posttranslational...
-
Article
Open AccessElectron stochastic acceleration in laboratory-produced kinetic turbulent plasmas
The origin of energetic charged particles in universe remains an unresolved issue. Astronomical observations combined with simulations have provided insights into particle acceleration mechanisms, including ma...
-
Article
Open AccessMultiplex LAMP assay for detecting the prevalent species of dust mites Dermatophagoides farinae and Dermatophagoides pteronyssinus in the domestic environment
Dermatophagoides farina (D. farinae) and Dermatophagoides pteronyssinus (D. pteronyssinus) are the prevalent kinds of house dust mites (HDMs). HDMs are common inhalant allergens that cause a range of allergic dis...
-
Article
Open AccessGeological evidence for extensive basin ejecta as plains terrains in the Moon’s South Polar Region
Water ice and other volatiles that accumulated in the Moon’s polar regions are among the top priority targets for lunar exploration, due to their significances in both lunar geology and extraterrestrial resour...
-
Article
Open AccessLow-input PacBio sequencing generates high-quality individual fly genomes and characterizes mutational processes
Long-read sequencing, exemplified by PacBio, revolutionizes genomics, overcoming challenges like repetitive sequences. However, the high DNA requirement ( > 1 µg) is prohibitive for small organisms. We develop...
-
Article
Open AccessReducing nonradiative recombination for highly efficient inverted perovskite solar cells via a synergistic bimolecular interface
Reducing interface nonradiative recombination is important for realizing highly efficient perovskite solar cells. In this work, we develop a synergistic bimolecular interlayer (SBI) strategy via 4-methoxypheny...
-
Article
Open AccessHealthcare resource utilization and economic burden of multiple sclerosis in Chinese patients: results from a real-world survey
Multiple sclerosis (MS) is uncommon in China and the standard of care is underdeveloped, with limited utilization of disease-modifying treatment (DMT). An understanding of real-world disease burden (including ...
-
Article
Open AccessCorrelation between bone mineral density and type 2 diabetes mellitus in elderly men and postmenopausal women
The relationship between bone mineral density and type 2 diabetes is still controversial. The aim of this study is to investigate the relationship between type 2 diabetes mellitus (T2DM) and bone mineral densi...
-
Article
Publisher Correction: Sex differences orchestrated by androgens at single-cell resolution
-
Article
Open AccessStudy on the Infrared and Raman spectra of Ti3AlB2, Zr3AlB2, Hf3AlB2, and Ta3AlB2 by first-principles calculations
In this paper, the crystal geometry, electronic structure, lattice vibration, Infrared and Raman spectra of ternary layered borides M3AlB2 (M = Ti, Zr, Hf, Ta) are studied by using first principles calculation me...
-
Article
Open AccessPIKfyve, expressed by CD11c-positive cells, controls tumor immunity
Cancer treatment continues to shift from utilizing traditional therapies to targeted ones, such as protein kinase inhibitors and immunotherapy. Mobilizing dendritic cells (DC) and other myeloid cells with anti...
-
Article
Open AccessSafety and efficacy of interventional embolization in cirrhotic patients with refractory hepatic encephalopathy associated with spontaneous portosystemic shunts
This study aimed to assess the safety and efficacy of interventional embolization in cirrhotic patients with refractory hepatic encephalopathy (HE) associated with large spontaneous portosystemic shunts (SPSS)...
-
Article
Open AccessNovel Alzheimer's disease subtypes based on functional brain connectivity in human connectome project
The pathogenesis of Alzheimer's disease (AD) remains unclear, but revealing individual differences in functional connectivity (FC) may provide insights and improve diagnostic precision. A hierarchical clusteri...
-
Article
Open AccessA morphological traits dataset of Heteroptera sampled in biodiversity priority areas of Southwest China
Functional traits reveal the adaptive strategies of species to their environment, and are relevant to the formation of communities, the function of ecosystems, and the mechanisms underlying biodiversity. Howev...
-
Article
Open AccessIon exchange-assisted surface passivation toward highly stable red-emitting fluoride phosphors for light-emitting diodes
A facile and environmentally friendly ion exchange-assisted surface passivation (IASP) strategy is presented for synthesizing red emitting Mn4+-activated fluoride phosphors. A substantial, pristine Mn4+-free shel...
-
Article
Open AccessResponses of growth and photosynthesis to alkaline stress in three willow species
Investigating differences in resistance to alkaline stress among three willow species can provide a theoretical basis for planting willow in saline soils. Therefore we tested three willow species (Salix matsudana
-
Article
Open AccessDistribution and molecular characterization of carbapenemase-producing gram-negative bacteria in Henan, China
This study aimed to investigate the epidemiological characteristics and trends over time of carbapenemase-producing (e.g., KPC, NDM, VIM, IMP, and OXA-48) Gram-negative bacteria (CPGNB). Non-duplicated multi-d...
-
Article
Open AccessPJA1-mediated suppression of pyroptosis as a driver of docetaxel resistance in nasopharyngeal carcinoma
Chemoresistance is a main reason for treatment failure in patients with nasopharyngeal carcinoma, but the exact regulatory mechanism underlying chemoresistance in nasopharyngeal carcinoma remains to be elucida...
-
Article
Open AccessA complete reference genome of broomcorn millet
Broomcorn millet (Panicum miliaceum L.), known for its traits of drought resistance, adaptability to poor soil, short growth period, and high photosynthetic efficiency as a C4 plant, represents one of the earlies...
-
Article
Open AccessCholesterol efflux from C1QB-expressing macrophages is associated with resistance to chimeric antigen receptor T cell therapy in primary refractory diffuse large B cell lymphoma
Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated promising efficacy in early trials for relapsed/refractory diffuse large B cell lymphoma (DLBCL). However, its efficacy in treating primary ref...