1,536 Result(s)
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**ao**g An
Biochemistry, general
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Article
Novel small multidrug resistance protein Tmt endows the Escherichia coli with triphenylmethane dyes bioremediation capability
Dye contamination in printing and dyeing wastewater has long been a major concern due to its serious impact on both the environment and human health. In the quest for bioremediation of these hazardous dyes, bi...
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Article
Open AccessRole of ferroptosis in radiation-induced soft tissue injury
Ionizing radiation has been pivotal in cancer therapy since its discovery. Despite its therapeutic benefits, IR causes significant acute and chronic complications due to DNA damage and the generation of reacti...
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Article
Open AccessPotent synergy and sustained bactericidal activity of polymyxins combined with Gram-positive only class of antibiotics versus four Gram-negative bacteria
Gram-negative bacteria (GNB) are becoming increasingly resistant to a wide variety of antibiotics. There are currently limited treatments for GNB, and the combination of antibiotics with complementary mechanis...
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Article
Clinical Characteristics and Prognosis of Early-Onset Hepatocellular Carcinoma: A Retrospective Cohort Study Based on Population Data
The incidence of young patients diagnosed with hepatocellular carcinoma (HCC) is projected to rise. This study aimed to investigate the distinctive characteristics of adolescent and young adult (AYA) patients ...
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The Role of Neuromodulation and Potential Mechanism in Regulating Heterotopic Ossification
Heterotopic ossification (HO) is a pathological process characterized by the aberrant formation of bone in muscles and soft tissues. It is commonly triggered by traumatic brain injury, spinal cord injury, and ...
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Article
Fluorescent carbon dots for discriminating cell types: a review
Carbon dots (CDs) are quasi-spherical carbon nanoparticles with excellent photoluminescence, good biocompatibility, favorable photostability, and easily modifiable surfaces. CDs, serving as fluorescent probes,...
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Article
Genome mining and physiological analyses uncover adaptation strategies and biotechnological potential of Virgibacillus dokdonensis T4.6 isolated from high-salt shrimp paste
Virgibacillus spp. stand out as a potent starter culture for accelerating the fermention of fish sauces and shrimp pastes. However, the underlying molecular mechanisms responsible for their adaptation and biotech...
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Article
SLC10A1 rs2296651 variant (S267F mutation) predicts biochemical traits, hepatitis B virus infection susceptibility and the risk of gallstone disease
Sodium taurocholate co-transporting polypeptide (NTCP), a bile acid transporter, plays a crucial role in regulating bile acid levels and influencing the risk of HBV infection. Genetic variations in the SLC10A1 ge...
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Article
A Highly Efficient D-Shaped Dual-Core PCF-SPR Sensor Coated with ITO Film for Refractive Index Detection
This study presents an investigation into a dual-core photonic crystal fiber (PCF) sensor featuring a D-shaped configuration. The sensor leverages surface plasmon resonance (SPR) to enable precise measurement ...
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Article
MicroRNA-361-5p Alleviates Leydig Cell Apoptosis and Promotes Cell Growth by Targeting PIAS1 in Late-Onset Hypogonadism
Late-onset hypogonadism (LOH) is an age-related syndrome characterized by deficiency of serum testosterone produced by Leydig cells. Previous evidence suggested that microRNA (miR)-361-3p can serve as a promis...
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Article
Impacts of Climate Change on the Distribution of Vietnamese Golden Cypress in Northern Vietnam
Climate change influences the geographic distribution of species, especially rare and endangered species such as the Vietnamese Golden Cypress (Xanthocyparis vietnamensis). In this study, we determined the key fa...
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Article
Repurposing of halogenated organic pollutants via alkyl bromide-catalysed transfer chlorination
Halogenated organic pollutants (HOPs) are causing a significant environmental and human health crisis due to their high levels of toxicity, persistence and bioaccumulation. Urgent action is required to develop...
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Article
3D spheroid HepaRG and fluorescent biphasic tracer for CYP3A4-mediated antibiotic interaction monitoring in sepsis
Cytochrome P450 3A4 (CYP3A4) is a crucial enzyme in the metabolism of xenobiotics, particularly in drug metabolism interactions (DDIs), making it a significant factor in clinical drug use. However, current ass...
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Article
Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer’s Disease
Neuroinflammation and endothelial cell apoptosis are prominent features of blood–brain barrier (BBB) disruption, which have been described in Alzheimer’s disease (AD) and can predict cognitive decline. Recent ...
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Article
Polarization Properties in GaN Double-Channel HEMTs at Mid-Infrared Frequencies
The polarization properties of grating-gate GaN-based high electron mobility transistors in the mid-infrared region have been investigated. However, due to the lack of research on the absorption characteristic...
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Article
Highly Sensitive Surface Plasmon Resonance Refractive Index Sensor Based on D-Shaped Dual‑Core Photonic Crystal Fiber with ITO Film
In this research, we proposed and numerically investigated a D-shaped dual-core photonic crystal fiber (PCF) refractive index (RI) sensor based on surface plasmon resonance (SPR), and a plasma material indium ...
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Article
Clarifying the four core effects of high-entropy materials
High-entropy materials emerged as a field of research in 2004, when the first research on high-entropy alloys was published. The scope was soon expanded from high-entropy alloys to medium-entropy alloys, as we...
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Article
Overexpression of Lias Gene Alleviates Cadmium-Induced Kidney Injury in Mice Involving Multiple Effects: Metabolism, Oxidative Stress, and Inflammation
Oxidative stress is an important mechanism underlying toxicity induced by cadmium (Cd) exposure. However, there are significant differences of the antioxidant baseline in different populations. This means that...
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Article
Deprotonated 2-thiolimidazole serves as a metal-free electrocatalyst for selective acetylene hydrogenation
Metal-free catalysts offer a desirable alternative to traditional metal-based electrocatalysts. However, metal-free catalysts, featuring defined active sites, rarely show activities as promising as metal-based...
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Article
Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis
Sphingomyelin (SM) has key roles in modulating mammalian membrane properties and serves as an important pool for bioactive molecules. SM biosynthesis is mediated by the sphingomyelin synthase (SMS) family, com...
