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Chapter and Conference Paper
Study on the Compatibility Between Steel Slag-Based Admixture and Polycarboxylate Superplasticizer Based on the Marsh Method
Poor compatibility between water reducing agent and cement can lead to rapid loss of concrete fluidity and slump, and mineral admixtures will affect the compatibility between water reducing agents and cement. ...
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Article
Open AccessDefine cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials
Despite centuries since the discovery and study of cancer, cancer is still a lethal and intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much attention as a pivotal compone...
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Article
Open AccessArtificial intelligence learning landscape of triple-negative breast cancer uncovers new opportunities for enhancing outcomes and immunotherapy responses
Triple-negative breast cancer (TNBC) is a relatively aggressive breast cancer subtype due to tumor relapse, drug resistance, and multi-organ metastatic properties. Identifying reliable biomarkers to predict pr...
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Article
Open AccessEvidence for the utility of quantum computing before fault tolerance
Quantum computing promises to offer substantial speed-ups over its classical counterpart for certain problems. However, the greatest impediment to realizing its full potential is noise that is inherent to thes...
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Article
Open AccessPatient-derived xenograft models in cancer therapy: technologies and applications
Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted into immunocompromised or humanized mice, have shown superiority in recapitulating the characteristics of cancer, such...
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Article
Open AccessPathogenicity, colonization, and innate immune response to Pasteurella multocida in rabbits
Pasteurella multocida (P. multocida) infection can cause a series of diseases in different animals and cause huge economic losses to the breeding industry. P. multocida is considered to be one of the most signif...
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Article
Open AccessAbnormal TNS3 gene methylation in patients with congenital scoliosis
Congenital scoliosis (CS) is a congenital deformity of the spine resulting from abnormal and asymmetrical development of vertebral bodies during pregnancy. However, the etiology and mechanism of CS remain uncl...
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Article
Open AccessImmune checkpoint modulators in cancer immunotherapy: recent advances and emerging concepts
The discovery of immune checkpoint inhibitors (ICIs) has now been universally acknowledged as a significant breakthrough in tumor therapy after the targeted treatment of checkpoint molecules: anti-programmed c...
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Article
Learning to detect soft shadow from limited data
Soft shadow is more challenging to detect than hard shadow due to its ambiguous boundary. Existing shadow detection methods pay more attention to hard shadow scene since collecting and annotating hard shadow i...
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Article
Single-image shadow removal using detail extraction and illumination estimation
Deep learning-based shadow removal methods are frequently hard to obtain a detail-rich and boundary-smoothing shadow removal result. In this work, we propose an illumination-sensitive filter and a multi-task g...
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Article
Open AccessPathogenicity comparison between QX-type and Mass-type infectious bronchitis virus to different segments of the oviducts in laying phase
The QX-type infectious bronchitis virus (IBV) has become the predominant genotype worldwide in recent years and has caused serious economic losses to the chicken industry. The most significant feature of QX IB...
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Article
Open AccessGlioma targeted therapy: insight into future of molecular approaches
Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically, gliomas occur among all ages, more often seen in adults, which males are more susceptible than females. According to...
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Article
Open AccessAntibiotic resistance of Mycoplasma Synoviae strains isolated in China from 2016 to 2019
In the past decade, Mycoplasma synoviae (M. synoviae) infection has become widely prevalent in China, has caused serious economic losses and has become one of the most important diseases in the chicken industry. ...
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Article
Open AccessIntratumor heterogeneity: the hidden barrier to immunotherapy against MSI tumors from the perspective of IFN-γ signaling and tumor-infiltrating lymphocytes
In this era of precision medicine, with the help of biomarkers, immunotherapy has significantly improved prognosis of many patients with malignant tumor. Deficient mismatch repair (dMMR)/microsatellite instabi...
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Article
Open AccessRegulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer
The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)/B7 and programmed death 1 (PD-1)/ programmed cell death-ligand 1 (PD-L1) are two most representative immune checkpoint pathways, which negatively regula...
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Article
Open AccessB2M overexpression correlates with malignancy and immune signatures in human gliomas
Because of the limited treatment strategy of gliomas, the key of diagnosis and treatment is finding new molecular biomarkers. Here, we explored the potential of β2-microglobulin (B2M) to serve as a hopeful can...
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Article
Hyperprogressive disease in patients with advanced renal cell carcinoma: a new pattern of post-treatment cancer behavior
Renal cell carcinoma (RCC) is among the most common cancers of the genitourinary system. Once RCC has progressed to a high tumor stage, surgery is no longer the optimal option, and treatment with drugs is more...
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Article
Open AccessEvaluation of the reproductive system development and egg-laying performance of hens infected with TW I-type infectious bronchitis virus
The prevalence of TW I-type infectious bronchitis virus (IBV) has been increasing rapidly, and it has become the second most common genotype of IBV in China threatening the poultry industry. In this study, 1-d...
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Article
Open AccessHigh methylation of lysine acetyltransferase 6B is associated with the Cobb angle in patients with congenital scoliosis
The etiology of congenital scoliosis (CS) is complex and uncertain. Abnormal DNA methylation affects the growth and development of spinal development. In this study, we investigated the role of DNA methylation...
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Article
Intrinsic kinetics and external diffusion of catalytic steam gasification of fine coal char particles under pressurized and fluidized conditions
Catalytic steam gasification of fine coal char particles was carried out using a self-made laboratory reactor to determine the intrinsic kinetics and external diffusion under varying pressures (0.1–0.5 MPa) an...
