-
Article
Mammalian IRE1α dynamically and functionally coalesces with stress granules
Upon endoplasmic reticulum (ER) stress, activation of the ER-resident transmembrane protein kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1) initiates a key branch of the unfolded protein response (U...
-
Article
Open AccessThe impact of multi-drug resistant Pseudomonas aeruginosa infections on acute pancreatitis patients
Acute pancreatitis (AP) accounts for a high proportion of digestive diseases worldwide and has a high risk of infection. Pseudomonas aeruginosa, a common pathogen of hospital infections, has been observed to incr...
-
Article
Targeted capture enrichment and sequencing identifies HLA variants associated with the severity of COVID-19
Coronavirus disease 2019 (COVID-19) is currently a global pandemic. The pathogenesis of severe COVID-19 has been widely investigated, but it is still unclear. Human leukocyte antigen (HLA) plays a central role...
-
Article
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis
Adipose tissue undergoes thermogenic remodeling in response to thermal stress and metabolic cues, playing a crucial role in regulating energy expenditure and metabolic homeostasis. Endoplasmic reticulum (ER) s...
-
Article
Open AccessRisk Factors for Mortality Among Critical Acute Pancreatitis Patients with Carbapenem-Resistant Organism Infections and Drug Resistance of Causative Pathogens
Carbapenem-resistant organisms (CRO) have emerged as a major global public health threat, but their role in critical acute pancreatitis (CAP) is still not defined. Our study aims to investigate risk factors as...
-
Article
Open AccessNeutralizing activity of BBIBP-CorV vaccine-elicited sera against Beta, Delta and other SARS-CoV-2 variants of concern
The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the generation of variants that may diminish host immune responses to vaccine formulations. Here we show a re...
-
Article
Open AccessBDNF-TrkB signaling-mediated upregulation of Narp is involved in the antidepressant-like effects of (2R,6R)-hydroxynorketamine in a chronic restraint stress mouse model
Preclinical studies have indicated that the ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) is a rapid-acting antidepressant drug with limited dissociation properties and low abuse potential. However, its ef...
-
Article
Liquid-phase deposition functionalized wood sponges for oil/water separation
Due to frequent industrial wastewater discharge and oil spills, there is a need to develop sustainable and efficient absorbents and treatment methods. Herein, based on the unique microstructure of wood and fun...
-
Article
Open AccessComprehensive analysis of the MIR4435-2HG/miR-1-3p/MMP9/miR-29-3p/DUXAP8 ceRNA network axis in hepatocellular carcinoma
A growing number of studies have shown that competitive endogenous RNA (ceRNA) regulatory networks might play important roles during the process of hepatocellular carcinoma (HCC). This study assessed the role ...
-
Article
Open AccessPredictors of mortality in acute pancreatitis complicated with multidrug-resistant Klebsiella pneumoniae infection
Multidrug-resistant (MDR) Klebsiella pneumoniae infections, from pancreatic infections to bloodstream infections, influence the mortality of patients with acute pancreatitis (AP) on the condition of limited antib...
-
Article
Open AccessPredictors of Mortality and Drug Resistance Among Carbapenem-Resistant Enterobacteriaceae-Infected Pancreatic Necrosis Patients
Carbapenem-resistant Enterobacteriaceae (CRE) has emerged as a global threat to hospitalization patients. Infected pancreatic necrosis (IPN) leads to high risks of CRE infections with increasing mortality. Our st...
-
Article
Effect of chemical composition of bamboo fibers on water sorption
Despite the robust mechanical properties of bamboo, interaction with water can result in the instability of these properties. Hygroscopicity is closely related to the chemical content of bamboo. Here, we explo...
-
Article
Open AccessMachine learning predicts lymph node metastasis of poorly differentiated-type intramucosal gastric cancer
To construct a machine learning algorithm model of lymph node metastasis (LNM) in patients with poorly differentiated-type intramucosal gastric cancer. 1169 patients with postoperative gastric cancer were divi...
-
Article
Open AccessSynergistic effects of tung oil and heat treatment on physicochemical properties of bamboo materials
The search for green and sustainable modification method to produce durable bamboo materials remains a challenge in industry. Here, heat treatment in tung oil at 100–200 °C was employed to modify bamboo materi...
-
Article
Association between STAT4 polymorphisms and risk of primary biliary cholangitis: a meta-analysis
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease. Several studies reported that SATA4 (signal transducer and activator of transcription 4) polymorphisms were significantly associated wit...
-
Article
An efficient model for auxiliary diagnosis of hepatocellular carcinoma based on gene expression programming
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. The early diagnosis of HCC is greatly helpful to achieve long-term disease-free survival. However, HCC is usually difficult ...
-
Article
Inhibition of neddylation by MLN4924 improves neointimal hyperplasia and promotes apoptosis of vascular smooth muscle cells through p53 and p62
Targeting apoptosis of vascular smooth muscle cells (VSMCs) represents an attractive approach to diminish the occurrence of restenosis. Neddylation is a highly conserved post-translational modification process...
-
Article
Microsatellite records for volume 9, issue 3
-
Article
piRNA-3878 targets P450 (CpCYP307B1) to regulate pyrethroid resistance in Culex pipiens pallens
Piwi-interacting RNAs (piRNAs) are a novel class of noncoding single-strand RNAs. They play an important role in the germ cell maintenance, brain development, epigenetic regulation of cancer, and antiviral fun...
-
Article
The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity
‘Crown-like’ structures composed of apoptotic adipocytes surrounded by adipose tissue macrophages (ATMs) are a characteristic of obesity. Liu and colleagues show that engulfment of apoptotic adipocytes trigger...
