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Article
Acid–Base Bifunctional Fiber as Highly Active Catalyst for the Tandem Deprotection-Knoevenagel Reaction
A serious of phenol and amine bifunctionalized polyacrylonitrile fibers have been prepared and used to catalyze the tandem deprotection-Knoevenagel reaction. Among them, the phenol and tertiary amine bifunctio...
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Article
Open AccessSemi-rational engineering an aldo–keto reductase for stereocomplementary reduction of α-keto amide compounds
Enantio-pure α-hydroxy amides are valuable intermediates for the synthesis of chiral pharmaceuticals. The asymmetric reduction of α-keto amides to generate chiral α-hydroxy amides is a difficult and challengin...
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Article
Porous sponge with surface modified for superhydrophobic/superoleophilic and special functionalization
Sponge-based materials have attracted wide attention because of their low cost, easy to manufacture and environmental-friendly. Sponge-based materials have the characteristics of large porosity and large speci...
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Article
Investigations of Chirality Effects on Undifferentiated State of Mesenchymal Stem Cells Using Soft Nanofibrous Oligopeptide Hydrogels
Soft nanofibrous oligopeptide hydrogels consisting of self-assembled l- and d-form Fmoc-Phe-Phe-Cys networks photo-cross-linked by poly(ethylene glycol)-dimethacrylate, which are referred to as l- and d-gel, resp...
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Article
Rational enhancement of enzyme-catalyzed enantioselective reaction by construction of recombinant enzymes based on additive strategy
A rational enhancement of kinetic resolution process for producing (S)-N-(2-ethyl-6-methylphenyl) alanine from racemic methyl ester using lipase B from Candida antarctica (CalB) was investigated. With the benefit...
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Article
Study on the enantioselectivity inhibition mechanism of acetyl-coenzyme A carboxylase toward haloxyfop by homology modeling and MM-PBSA analysis
Acetyl-coenzyme A carboxylase (ACCase) has been identified as one of the most important targets of herbicide Aryloxyphenoxypropionates (APPs). ACCase shows different enantioselectivity toward APPs, and only (R)-e...
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Article
l-Valine Dipeptide Organocatalysts with Two Amide Units for the Direct Asymmetric Aldol Reaction in Brine
A series of valine dipeptide organocatalysts containing a primary amine group and two amide units have been developed and evaluated in the direct asymmetric intermolecular aldol reaction of 4-nitrobenzaldehyde...