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Article
Open AccessHepatitis C virus subtype diversity and transmission clusters characteristics among drug users in Zhuhai, South China
Hepatitis C virus (HCV) infection poses a major public health challenge globally, especially among injecting drug users. China has the world’s largest burden of HCV infections. However, little is known about t...
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Article
Noise-tolerant zeroing neural network control for a novel compliant actuator in lower-limb exoskeletons
To enhance the safety of direct physical interaction between humans and lower-limb exoskeletons, the actuator of the lower-limb exoskeleton should possess compliance, force controllability, and back-drivabilit...
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Article
Open AccessEfficacy and safety of **an-Lian-Jie-Du optimization decoction as an adjuvant treatment for prevention of recurrence in patients with stage IIIB/IIIC colon cancer: study protocol for a multicentre, randomized controlled trial
Colon cancer remains one of the most prevalent cancers worldwide. Unfortunately, there are no recognized and effective therapeutic strategies to prevent tumor recurrence after radical resection and chemotherap...
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Article
Open AccessObject-aware Policy Network in Deep Recommender Systems
Deep learning has been successfully applied in the recommender system. Low-dimensional dense embedding is typically used to represent the feature of users and items. To optimize the model, some models propose ...
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Article
Open AccessCombination of Peglated-H1/HGFK1 Nanoparticles and TAE in the Treatment of Hepatocellular Carcinoma
Transarterial embolization (TAE) constitutes the gold standard for the treatment of hepatocellular carcinoma. The effect of combination of TAE and peglated-H1/HGFK1 nanoparticles was explored on hepatocellular...
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Article
Open AccessMETTL3 promotes colorectal carcinoma progression by regulating the m6A–CRB3–Hippo axis
Colorectal carcinoma (CRC) is the third most common cancer and second most common cause of cancer-related deaths worldwide. Ribonucleic acid (RNA) N6-methyladnosine (m6A) and methyltransferase-like 3 (METTL3) ...
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Chapter and Conference Paper
Disturbance Observer Compensation Based on Sliding-Mode Approach for Solving Compliant Actuator Tracking Control Problems
The rehabilitation robot needs directly physical interaction in the process of rehabilitation training for patients. Considering the safety of patients, the actuator of the rehabilitation robot should have the...
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Chapter and Conference Paper
Impedance Control of Upper Limb Rehabilitation Robot Based on Series Elastic Actuator
In this paper, to address motor dysfunction caused by factors such as stroke or traffic accidents, a kind of upper limb rehabilitation robot is designed for rehabilitation training. The rehabilitation robot is...
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Article
Open AccessNanobody-armed T cells endow CAR-T cells with cytotoxicity against lymphoma cells
Taking advantage of nanobodies (Nbs) in immunotherapy, we investigated the cytotoxicity of Nb-based chimeric antigen receptor T cells (Nb CAR-T) against lymphoma cells.
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Article
Open AccessThe underlying molecular mechanisms and prognostic factors of RNA binding protein in colorectal cancer: a study based on multiple online databases
RNA binding protein (RBP) is an active factor involved in the occurrence and development of colorectal cancer (CRC). Therefore, the potential mechanism of RBP in CRC needs to be clarified by dry-lab analyses o...
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Article
Open AccessCircRNA_0000392 promotes colorectal cancer progression through the miR-193a-5p/PIK3R3/AKT axis
Circular RNAs (circRNAs), important members of the noncoding RNA family, have been recently revealed to play a role in the pathogenic progression of diseases, particularly in the malignant progression of cance...
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Article
Open AccessRNA-Seq profiling of circular RNAs in human colorectal Cancer liver metastasis and the potential biomarkers
In this study, the secondary sequencing was used to profile circRNA expression in the tissue samples from three CRC patients with liver metastasis and three matched CRC patients. After verified some candidates...
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Article
Open AccessExtracts of Zuo ** Wan, a traditional Chinese medicine, phenocopies 5-HTR1D antagonist in attenuating Wnt/β-catenin signaling in colorectal cancer cells
In vitro and in vivo studies have shown that Zuo ** Wan (ZJW), a herbal formula of traditional Chinese medicine (TCM), possessed anticancer properties. However, the underlying mechanism for the action of ZJW ...
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Article
Open AccessMicroRNA-21 promotes hepatocellular carcinoma HepG2 cell proliferation through repression of mitogen-activated protein kinase-kinase 3
microRNA 21 (miR-21) has been demonstrated to be significantly elevated in many types of cancers, including the hepatocellular carcinoma (HCC). In the present study, we investigated the role of miR-21 in HCC b...
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Article
Prophylactic and therapeutic efficacy of the epitope vaccine CTB-UA against Helicobacter pylori infection in a BALB/c mice model
Epitope vaccine based on the enzyme urease of Helicobacter pylori is a promising option for prophylactic and therapeutic vaccination against H. pylori infection. In our previous study, the epitope vaccine CTB-UA,...
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Article
Cloning and identification of microRNAs in bovine alveolar macrophages
MicroRNAs (miRNAs) are a class of small non-coding RNAs found in both animal and plant cells. These ~19–26 nucleotide (nt) single-stranded RNAs play role in regulating gene/protein expression by either directl...
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Article
Effect of recombinant Mce4A protein of Mycobacterium bovis on expression of TNF-α, iNOS, IL-6, and IL-12 in bovine alveolar macrophages
The pathogenesis of tuberculosis-causing Mycobacterium bovis is largely due to its ability to enter and survive in alveolar macrophages. Its mechanism of entry, mediated by proteins encoded by mammalian cell entr...
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Article
Study on the covalence of Cu and chemical bonding in an inorganic fullerene-like molecule, [CuCl]20[Cp*FeP5]12 [Cu-(CH3CN)+ 2Cl-]5, by a density functional approach
The electronic structure and chemical bonding in a recently synthesized inorganic fullerene-like molecule, [CuCl]20[Cp*FeP5]12[Cu-(CH3CN) + 2Cl−]5 has been studied by a density functional ...
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Article
Coordination and phase separation in polyvinylpyrrolidone-neodymium chloride complex
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Article
Progress in the study on the composition and formation mechanism of gallstone
Our serial studies from {dy1970}s on chemical composition, structure determination and formation mechanism of gallstones were reviewed. The chemical component investigation of brown-pigment gallstone demonstra...
