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Article
Open AccessCACA guidelines for holistic integrative management of adult acute myeloid leukemia
The CACA Guidelines was summarized by Hematology Oncology Committee of China Anti- Cancer Association. This portion of the CACA Guidelines for adult acute myeloid leukemia (AML) not only focuses on diagnosis, ...
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Article
Open AccessPredicting lncRNA–protein interactions through deep learning framework employing multiple features and random forest algorithm
RNA-protein interaction (RPI) is crucial to the life processes of diverse organisms. Various researchers have identified RPI through long-term and high-cost biological experiments. Although numerous machine le...
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Article
USBE: User-similarity based estimator for multimedia cold-start recommendation
To address user cold-start challenge in multimedia recommender systems, we proposed a new model named USBE in this paper. The model doesn’t take the new user’s personal and social information as the necessary ...
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Article
Cooperative Global Path Planning for Multiple Unmanned Aerial Vehicles Based on Improved Fireworks Algorithm Using Differential Evolution Operation
Multiple unmanned aerial vehicles’ (multi-UAVs) cooperative global path planning is considered as a complexed nonlinear optimization problem. The improved hybrid fireworks algorithm with differential evolution...
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Article
Effects of Microwave Hybrid Sintering Methods and Nano-HfC Content on Mechanical Properties and Microstructure of TiB2-Based Cermets
A TiB2-based cermet tool material with excellent mechanical performance was rapidly prepared by microwave hybrid sintering. Microwave hybrid sintering is based on pure microwave sintering with the addition of hig...
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Article
HDAC inhibitor chidamide overcomes drug resistance in chronic myeloid leukemia with the T315i mutation through the Akt–autophagy pathway
Currently, therapy for Chronic Myeloid Leukemia (CML) patients with the T315I mutation is a major challenge in clinical practice due to its high degree of resistance to first- and second-generation Tyrosine Ki...
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Article
Open AccessReal-world data on efficacy and safety of azacitidine therapy in chronic myelomonocytic leukemia in China: results from a multicenter, retrospective study
Chronic myelomonocytic leukemia (CMML) is a rare and aggressive myeloid malignancy with overlapped features of myelodysplastic syndromes/myeloproliferative neoplasms. Azacitidine (AZA), a hypomethylating agent...
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Article
Open AccessProteomic profiling of plasma exosomes from patients with B-cell acute lymphoblastic leukemia
We aimed to comprehensively investigate the proteomic profile and underlying biological function of exosomal proteins associated with B-cell acute lymphoblastic leukemia. Exosomes were isolated from plasma sam...
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Article
Open AccessCHST15 gene germline mutation is associated with the development of familial myeloproliferative neoplasms and higher transformation risk
Herein, we describe the clinical and hematological features of three genetically related families predisposed to myeloproliferative neoplasms (MPNs). Using whole-exome sequencing, we identified a c.1367delG mutat...
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Chapter and Conference Paper
Orchard Energy Management to Improve Fruit Quality Based on the Internet of Things
The crop growth is an energy conversion process, and energy management has an important impact on the quality and yield of crop products. As IoT (the Internet of Things) is widely used in agriculture, for exam...
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Chapter and Conference Paper
UAV Path Planning Based on Hybrid Differential Evolution with Fireworks Algorithm
This paper considers the unmanned aerial vehicle (UAV) global path planning as an optimization problem with constraints and proposes a hybrid differential evolution with firework algorithm (HDEFWA) to generate...
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Article
The Effect of Synthesis Methods on Active Oxygen Species of MnOx-CuO in Soot Combustion
The activity of the catalyst is closely related to the synthesis method. Hereon, we prepared a series of XMn1Cu (X = 2, 4, 6, 8) catalysts by hydrolysis driven redox, co-precipitation and hydrothermal synthesi...
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Article
Open AccessThe JAK2 inhibitor TG101209 exhibits anti-tumor and chemotherapeutic sensitizing effects on Burkitt lymphoma cells by inhibiting the JAK2/STAT3/c-MYB signaling axis
Constitutive activation of JAK2/STAT3 is a major oncogenic signaling event involved in the development of Burkitt lymphoma (BL). In the present study, we investigated the antilymphoma activity of TG101209, a s...
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Article
Novel germline mutation KMT2A G3131S confers genetic susceptibility to familial myeloproliferative neoplasms
The current study analyzed the clinical and genetic characteristics of a family with familial myeloproliferative neoplasms (MPNs). Whole-exome sequencing was conducted, and a germline heterozygous mutation in ...
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Article
Open AccessLncRNA KCNQ1OT1 activated by c-Myc promotes cell proliferation via interacting with FUS to stabilize MAP3K1 in acute promyelocytic leukemia
Uncontrolled proliferation is the hallmark of cancer cells. Previous studies mainly focused on the role of protein-coding genes in cancer cell proliferation. Emerging evidence showed that long non-coding RNAs ...
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Chapter and Conference Paper
Research on Proofreading Method of Semantic Collocation Error in Chinese
With the rapid development of network technology and the popularization of electronic documents, Chinese text automatic proofreading technology has attracted increasing attention. Automatic proofreading of sem...
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Article
Open AccessA small molecular compound CC1007 induces cross-lineage differentiation by inhibiting HDAC7 expression and HDAC7/MEF2C interaction in BCR-ABL1− pre-B-ALL
Histone deacetylase 7 (HDAC7), a member of class IIa HDACs, has been described to be an important regulator for B cell development and has a potential role in B cell acute lymphoblastic leukemia (B-ALL). CC100...
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Article
A personalized recommendation algorithm based on large-scale real micro-blog data
With the arrival of the big data era, the amount of micro-blog users and texts is constantly increasing, and research on personalized recommendation algorithm for micro-blog texts is becoming more and more urg...
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Article
A novel NAP1L4/NUTM1 fusion arising from translocation t(11;15)(p15;q12) in a myeloid neoplasm with eosinophilia and rearrangement of PDGFRA highlights an unusual clinical feature and therapeutic reaction
NUT midline carcinoma (NMC) is an aggressive neoplasm and mainly involved in the head and neck area. The defining genetic hallmark on these tumors is that testis-specific nuclear gene (NUTM1) fuses to bromodomain...
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Chapter and Conference Paper
Cached Embedding with Random Selection: Optimization Technique to Improve Training Speed of Character-Aware Embedding
Embedding is widely used in most natural language processing. e.g., neural machine translation, text classification, text abstraction and sentiment analysis etc. Word-based embedding is faster and character-b...
