Normative Readings of the Belt and Road Initiative
Road to New Paradigms
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Interstitial Strengthening of a Cast and Wrought Ni-Based Heavy Density Matrix Alloy by Carbon Addition
An interstitial strengthened Ni-based heavy-density matrix alloy (Ni-37W-19Co-xC) was prepared by conventional casting and wrought metallurgy techniques, and the effect of carbon addition on the microstructure...
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Exploring Novel Fentanyl Analogues Using a Graph-Based Transformer Model
The structures of fentanyl and its analogues are easy to be modified and few types have been included in database so far, which allow criminals to avoid the supervision of relevant departments. This paper intr...
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Open AccessGlioma-targeted oxaliplatin/ferritin clathrate reversing the immunosuppressive microenvironment through hijacking Fe2+ and boosting Fenton reaction
Glioma is easy to develop resistance to temozolomide (TMZ). TMZ-resistant glioma secretes interleukin-10 (IL-10) and transforming growth factor-β (TGF-β), recruiting regulatory T cell (Treg) and inhibiting the ac...
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Open AccessCyclosporine A loaded brain targeting nanoparticle to treat cerebral ischemia/reperfusion injury in mice
Ischemic stroke is one of the main causes of death and disability in the world. The treatment for ischemic stroke is to restore blood perfusion as soon as possible. However, when ischemic brain tissue is re-pe...
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Open AccessTregs biomimetic nanoparticle to reprogram inflammatory and redox microenvironment in infarct tissue to treat myocardial ischemia reperfusion injury in mice
At present, patients with myocardial infarction remain an increased risk for myocardial ischemia/reperfusion injury (MI/RI). There lacks effectively method to treat MI/RI in clinic. For the treatment of MI/RI,...
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Open AccessBiomimetic GBM-targeted drug delivery system boosting ferroptosis for immunotherapy of orthotopic drug-resistant GBM
Clinical studies have shown that the efficacy of programmed cell death receptor-1/programmed cell death ligand-1 (PD-1/PD-L1) inhibitors on glioblastoma (GBM) is much lower than what is expected because of the...
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Correction to: Porcine Picornavirus 3C Protease Degrades PRDX6 to Impair PRDX6-mediated Antiviral Function
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Open AccessMCP mediated active targeting calcium phosphate hybrid nanoparticles for the treatment of orthotopic drug-resistant colon cancer
Colon cancer is a most common malignant cancer in digestive system, and it is prone to develop resistance to the commonly used chemotherapy drugs, leading to local recurrence and metastasis. Paris saponin VII ...
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Porcine Picornavirus 3C Protease Degrades PRDX6 to Impair PRDX6-mediated Antiviral Function
Peroxiredoxin-6 (PRDX6) is an antioxidant enzyme with both the activities of peroxidase and phospholipase A2 (PLA2), which is involved in regulation of many cellular reactions. However, the function of PRDX6 d...
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Microstructure Evolution and Wear Resistance Control of Water Quenching Si-Mn-Mo Cast Steel
The effect of austenitizing temperatures at 850, 880, 910, 940, 970 and 1000 °C, respectively, and tempering at 250 °C on the microstructure, mechanical properties, strengthening and toughening mechanism, and ...
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The Effect of Silicon on Microstructure and Wear Resistance in Bainitic Steel
The microstructure, hardness and sliding wear behavior of bainitic steel containing 1.0–2.5% Si were investigated by means of the optical microscope, the scanning electron microscope, the X-ray diffraction, en...
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Open AccessRIG-I is responsible for activation of type I interferon pathway in Seneca Valley virus-infected porcine cells to suppress viral replication
Retinoic acid-inducible gene I (RIG-I) is a key cytosolic receptor of the innate immune system. Seneca valley virus (SVV) is a newly emerging RNA virus that infects pigs causing significant economic losses in ...
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Open AccessDiscovering the ‘Dark matters’ in expression data of miRNA based on the miRNA-mRNA and miRNA-lncRNA networks
Since miRNAs can play important roles in different cancer types, how to discover cancer related miRNAs is an important issue. In general, the miRNAs with differential expression is the focus of attention. Howe...
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A Tale of Ending Poverty: The New Financial Institutions and China’s Global Strategy
The term “end-poverty” is adopted by the World Bank (WB) in working with the Asian Infrastructure Investment Bank (AIIB) and countries within the sphere of influence of the Belt and Road Initiative (BRI). This...
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Open AccessDevelopment of real-time and lateral flow dipstick recombinase polymerase amplification assays for rapid detection of goatpox virus and sheeppox virus
Goatpox virus (GTPV) and sheeppox virus (SPPV), which belong to the Capripoxvirus (CaPV), are economically important pathogens of small ruminants. Therefore, a sensitive, specific and rapid diagnostic assay for d...
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Open AccessFoot-and-mouth disease virus infection inhibits LGP2 protein expression to exaggerate inflammatory response and promote viral replication
The role of the innate immune protein LGP2 (laboratory of genetics and physiology 2) in FMDV-infected cells remains unknown. Here, we demonstrate the antiviral role of LGP2 during FMDV infection. FMDV infectio...
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Differential gene expression in porcine SK6 cells infected with wild-type and SAP domain-mutant foot-and-mouth disease virus
Foot-and-mouth disease virus (FMDV) is the causative agent of a highly contagious disease in livestock. The viral proteinase Lpro of FMDV is involved in pathogenicity, and mutation of the Lpro SAP domain reduces ...
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Characterization of temperature non-uniformity over a premixed CH4–air flame based on line-of-sight TDLAS
A novel technique for characterizing temperature non-uniformity has been investigated based on measurements of line-of-sight tunable diode laser absorption spectroscopy. It utilized two fiber-coupled distribut...
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Association of CDKN1B gene polymorphisms with susceptibility to breast cancer: a meta-analysis
A number of case–control studies have been conducted to investigate the association of CDKN1B gene polymorphisms with breast cancer. However, these studies reported conflicting results. The aim of our study wa...
