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Open AccessA pan-KRAS degrader for the treatment of KRAS-mutant cancers
KRAS mutations are highly prevalent in a wide range of lethal cancers, and these mutant forms of KRAS play a crucial role in driving cancer progression and conferring resistance to treatment. While there have bee...
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Article
Open AccessA novel surgical scheme for hepatectomy in hepatocellular carcinoma patients with clinically significant portal hypertension
Clinically significant portal hypertension (CSPH) seriously affects the feasibility and safety of surgical treatment for hepatocellular carcinoma (HCC) patients. The aim of this study was to establish a new su...
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Article
Open AccessMulti-view Heterogeneous Graph Neural Networks for Node Classification
Recently, with graph neural networks (GNNs) becoming a powerful technique for graph representation, many excellent GNN-based models have been proposed for processing heterogeneous graphs, which are termed Hete...
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Article
Open AccessTanshinone IIA is superior to paricalcitol in ameliorating tubulointerstitial fibrosis through regulation of VDR/Wnt/β-catenin pathway in rats with diabetic nephropathy
Glomerulosclerosis and tubulointerstitial fibrosis (TIF) are closely involved in the development of diabetic nephropathy (DN). Moreover, the development of TIF is closely related to epithelial-to-mesenchymal t...
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Article
Open AccessP. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway
Benign prostatic hyperplasia (BPH) is the most common disease in elderly men. There is increasing evidence that periodontitis increases the risk of BPH, but the specific mechanism remains unclear. This study a...
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Open AccessRemnant cholesterol and the risk of aortic valve calcium progression: insights from the MESA study
Remnant cholesterol (RC) is implicated in the risk of cardiovascular disease. However, comprehensive population-based studies elucidating its association with aortic valve calcium (AVC) progression are limited...
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Article
Open AccessAn immortal porcine preadipocyte cell strain for efficient production of cell-cultured fat
Adding adipose cells to cell-cultured meat can provide a distinctive aroma and juicy texture similar to real meat. However, a significant challenge still exists in obtaining seed cells that can be propagated f...
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Open AccessThe optimal intravesical maintenance chemotherapy scheme for the intermediate-risk group non-muscle-invasive bladder cancer
Although the current European Association of Urology(EAU) guideline recommends that patients with intermediate-risk non-muscle-invasive bladder cancer (NMIBC) should accept intravesical chemotherapy or Calmett...
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Open AccessDeciphering intratumoral heterogeneity of hepatocellular carcinoma with microvascular invasion with radiogenomic analysis
The recurrence and metastasis of hepatocellular carcinoma (HCC) are mainly caused by microvascular invasion (MVI). Our study aimed to uncover the cellular atlas of MVI+ HCC and investigate the underlying immune i...
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Open AccessResearch on the development methodology for clinical practice guidelines for organic integration of traditional Chinese and Western medicine
Integrated traditional Chinese medicine (TCM) and Western medicine (WM) is a new medical science grounded in the knowledge bases of both TCM and WM, which then forms a unique modern medical system in China. In...
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Open AccessGrowth hormone reduces aneuploidy and improves oocytes quality by JAK2-MAPK3/1 pathway in aged mice
The global delay in women’s reproductive age has raised concerns about age-related infertility. The decline in oocyte quality is a limiting factor of female fertility, yet there are currently no strategies to ...
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Open AccessThe facilitating role of phycospheric heterotrophic bacteria in cyanobacterial phosphonate availability and Microcystis bloom maintenance
Phosphonates are the main components in the global phosphorus redox cycle. Little is known about phosphonate metabolism in freshwater ecosystems, although rapid consumption of phosphonates has been observed fr...
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Author Correction: The power of genetic diversity in genome-wide association studies of lipids
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Open AccessExploring lemology teaching with “internet plus” flipped classroom pedagogy
To investigate the use of flipped classroom pedagogy based on “Internet plus” in teaching viral hepatitis in the lemology course during the COVID-19 epidemic.
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Open AccessWhole fresh fruit intake and risk of incident diabetes in different glycemic stages: a nationwide prospective cohort investigation
Fruit intake is beneficial to several chronic diseases, but controversial in diabetes. We aimed to investigate prospectively the associations of whole fresh fruit intake with risk of incident type 2 diabetes (...
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Article
Open AccessImplicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understandi...
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Open AccessTargeting the cholesterol-RORα/γ axis inhibits colorectal cancer progression through degrading c-myc
Dysregulated cholesterol metabolism is a hallmark of colorectal cancer (CRC). However, the usage of cholesterol-lowering agents seemed to have no benefit in CRC patients. In this study, we focused on the chole...
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Article
Open AccessDNA-PKcs participated in hypoxic pulmonary hypertension
Hypoxic pulmonary hypertension (HPH) is a common complication of chronic lung disease, which severely affects the survival and prognosis of patients. Several recent reports have shown that DNA damage and repai...
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Article
Open AccessSphingolipids in plant immunity
Sphingolipids (lipids with a sphingoid base backbone) are important components of eukaryotic membrane systems and key signaling molecules that are essential for controlling cellular homeostasis, acclimating to...
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Article
Open AccessAssociations of plasma angiostatin and amyloid-β and tau levels in Alzheimer’s disease
Angiostatin, an endogenous angiogenesis inhibitor generated by the proteolytic cleavage of plasminogen, was recently reported to contribute to the development of Alzheimer’s disease (AD). However, whether ther...
