156 Result(s)

Article

PJA1-mediated suppression of pyroptosis as a driver of docetaxel resistance in nasopharyngeal carcinoma

Chemoresistance is a main reason for treatment failure in patients with nasopharyngeal carcinoma, but the exact regulatory mechanism underlying chemoresistance in nasopharyngeal carcinoma remains to be elucida...

Sheng-Yan Huang, Sha Gong, Yin Zhao, Ming-Liang Ye, Jun-Yan Li… in Nature Communications (2024)

Article

PD-1/CD80⁺ small extracellular vesicles from immunocytes induce cold tumours featured with enhanced adaptive immunosuppression

Only a minority of cancer patients benefit from immune checkpoint blockade therapy. Sophisticated cross-talk among different immune checkpoint pathways as well as interaction pattern of immune checkpoint molec...

Lin-Zhou Zhang, Jie-Gang Yang, Gai-Li Chen, Qi-Hui **e, Qiu-Yun Fu… in Nature Communications (2024)

Article

Curcumin regulates autophagy through SIRT3-SOD2-ROS signaling pathway to improve quadriceps femoris muscle atrophy in KOA rat model

Knee osteoarthritis (KOA) usually leads to quadriceps femoris atrophy, which in turn can further aggravate the progression of KOA. Curcumin (CUR) has anti-inflammatory and antioxidant effects and has been show...

Hua Ye, Yi Long, Jia-Ming Yang, Yan-Lin Wu, Ling-Yan Dong… in Scientific Reports (2024)

Article

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes^1,2 and molecular mechanisms that are often specific to cell type^3,4. Here, to characterize the genetic c...

Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J. Taylor… in Nature (2024)

Article

Low pressure reversibly driving colossal barocaloric effect in two-dimensional vdW alkylammonium halides

Plastic crystals as barocaloric materials exhibit the large entropy change rivalling freon, however, the limited pressure-sensitivity and large hysteresis of phase transition hinder the colossal barocaloric ef...

Yi-Hong Gao, Dong-Hui Wang, Feng-**a Hu, Qing-Zhen Huang… in Nature Communications (2024)

Article

Author Correction: Visible-light-driven Photocatalytic N-arylation of Imidazole Derivatives and Arylboronic Acids on Cu/graphene catalyst

Yan-Li Cui, **ao-Ning Guo, Ying-Yong Wang, **ang-Yun Guo in Scientific Reports (2024)

Article

Enhanced formation of methane hydrate from active ice with high gas uptake

Gas hydrates provide alternative solutions for gas storage & transportation and gas separation. However, slow formation rate of clathrate hydrate has hindered their commercial development. Here we report a for...

Peng **ao, Juan-Juan Li, Wan Chen, Wei-**n Pang, **ao-Wan Peng… in Nature Communications (2023)

Article

Relationship between body composition and pulmonary function in the general population—a cross-sectional study in Ningxia

Studies considering the relationship between non-obesity-related body composition and lung function are few; therefore, this study aimed to explore these correlations and effects. This cross-sectional study co...

Yang-yang Pi, Wen-xuan Hu, Zi-ming Jiao, Peng-yi Hou, Yu-hong Zhang… in Scientific Reports (2023)

Article

Chronic cough relief by allosteric modulation of P2X3 without taste disturbance

P2X receptors are cation channels that sense extracellular ATP. Many therapeutic candidates targeting P2X receptors have begun clinical trials or acquired approval for the treatment of refractory chronic cough...

Chang-Run Guo, Zhong-Zhe Zhang, **ng Zhou, Meng-Yang Sun… in Nature Communications (2023)

Article

Improving quantitation accuracy in isobaric-labeling mass spectrometry experiments with spectral library searching and feature-based peptide-spectrum match filter

Isobaric labeling relative quantitation is one of the dominating proteomic quantitation technologies. Traditional quantitation pipelines for isobaric-labeled mass spectrometry data are based on sequence databa...

Tzu-Yun Kuo, Jen-Hung Wang, Yung-Wen Huang, Ting-Yi Sung… in Scientific Reports (2023)

Article

Diploid and tetraploid genomes of Acorus and the evolution of monocots

Monocots are a major taxon within flowering plants, have unique morphological traits, and show an extraordinary diversity in lifestyle. To improve our understanding of monocot origin and evolution, we generate...

Liang Ma, Ke-Wei Liu, Zhen Li, Yu-Yun Hsiao, Yiying Qi, Tao Fu… in Nature Communications (2023)

Article

Absence of critical thickness for polar skyrmions with breaking the Kittel’s law

The period of polar domain (d) in ferroics was commonly believed to scale with corresponding film thicknesses (h), following the classical Kittel’s law of d ∝

Feng-Hui Gong, Yun-Long Tang, Yu-Jia Wang, Yu-Ting Chen, Bo Wu… in Nature Communications (2023)

Article

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham, Shoa L. Clarke, Kuan-Han H. Wu, Stavroula Kanoni… in Nature (2023)

Article

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study o...

Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo… in Nature Communications (2023)

Article

Risk analysis for patients with arterial thromboembolic events after intravitreal ranibizumab or aflibercept injections

Intravitreal anti–vascular endothelial growth factor (anti-VEGF) agents have been increasingly applied in the treatment of retinal neovascular diseases. Concerns have arisen that these intravitreal agents may ...

Yun-I. Chou, Hao-Yun Chang, Meng-Yin Lin, Ching-Han Tseng… in Scientific Reports (2023)

Article

The functional change of the P2X7R containing the Ala³⁴⁸ to Thr polymorphism is associated with the pathogenesis of gout

Our previous study has shown that ATP action on P2X7R could be the second signal to induce the onset of gouty arthritis. However, the functional changes of P2X7R single nucleotide polymorphisms (SNPs) on the e...

Man-Yun Li, Xuan Fang, Yan Ma, **an-Yang Pan, **ao-Juan Dai… in Scientific Reports (2023)

Article

First-in-human phase Ia study of the PI3Kα inhibitor CYH33 in patients with solid tumors

PIK3CA mutations are highly prevalent in solid tumors. Targeting phosphatidylinositol 3-kinase α is therefore an attractive strategy for treating cancers harboring PIK3CA mutations. Here, we report the results fr...

**ao-Li Wei, Fu-Rong Liu, Ji-Hong Liu, Hong-Yun Zhao, Yang Zhang… in Nature Communications (2022)

Article

Predicting willingness to donate blood based on machine learning: two blood donor recruitments during COVID-19 outbreaks

Machine learning methods are a novel way to predict and rank donors' willingness to donate blood and to achieve precision recruitment, which can improve the recruitment efficiency and meet the challenge of blo...

Hong-yun Wu, Zheng-gang Li, **n-kai Sun, Wei-min Bai, An-di Wang… in Scientific Reports (2022)

Article

Sirtuin5 protects colorectal cancer from DNA damage by kee** nucleotide availability

In our previous study, we reported that sirtuin5 (SIRT5), a member of the NAD⁺-dependent class III histone deacetylase family, is highly expressed in colorectal cancer (CRC). Herein we show that SIRT5 knockdown i...

Hao-Lian Wang, Yan Chen, Yun-Qian Wang, En-Wei Tao, Juan Tan… in Nature Communications (2022)

Article

Particulate matter may have a limited influence on maternal vitamin D levels

Evidence for an association between the amount of particulate matter (PM) in the atmosphere and vitamin D status of pregnant women is limited. We aimed to examine the independent association between PM and mat...

Chong Li, Ya-qin Gong, Yun-yu **a, **ao-chun Wang, Lin Chen… in Scientific Reports (2022)