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214 Result(s)
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Article
Structural basis of the α1–β subunit interaction of voltage-gated Ca2+ channels
High-voltage-activated Ca2+ channels are essential for diverse biological processes. They are composed of four or five subunits, including α1, α2-δ, β and γ (ref. 1). Their expression and function are critically ...
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Article
A conserved inverted repeat from rice plastome functions as an intrinsic transcription terminator
Results from a previous rice transcription map** and the GeSTer algorithm analysis used in this in-vestigation for rice plastid genome suggest that an inverted repeat, IRsl8, in 3′ region of the plastid rps18 g...
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Article
Early Cambrian ocean anoxia in South China
Arising from: M. Wille, T. F. Nägler, B. Lehmann, S. Schröder & J. D. Kramers Nature 453, 767–769 (2008)10.1038/nature07072; Wille et al.
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Article
Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex
Polycystic kidney disease (PKD) family proteins associate with transient receptor potential (TRP) channel family proteins to form functionally important complexes. PKD proteins differ from known ion channel-fo...
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Article
Open AccessA Photometric High-Throughput Method for Identification of Electrochemically Active Bacteria Using a WO3 Nanocluster Probe
Electrochemically active bacteria (EAB) are ubiquitous in environment and have important application in the fields of biogeochemistry, environment, microbiology and bioenergy. However, rapid and sensitive meth...
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Article
Open AccessPerformance of breast cancer screening methods and modality among Chinese women: a report from a society-based breast screening program (SBSP) in Shanghai
To evaluate the screening performance of individual and combined use of clinical breast examination, ultrasonography and mammography in Chinese women, we conducted a biennial breast cancer screening program am...
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Open AccessLight trap** and surface plasmon enhanced high-performance NIR photodetector
Heterojunctions near infrared (NIR) photodetectors have attracted increasing research interests for their wide-ranging applications in many areas such as military surveillance, target detection and light visio...
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Open AccessThe complex jujube genome provides insights into fruit tree biology
The jujube (Ziziphus jujuba Mill.), a member of family Rhamnaceae, is a major dry fruit and a traditional herbal medicine for more than one billion people. Here we present a high-quality sequence for the complex ...
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Open AccessConcurrent radiotherapy and weekly chemotherapy of 5-fluorouracil and platinum agents for postoperative locoregional recurrence of oesophageal squamous cell carcinoma
The most optimal management for postoperative locoregional recurrence of oesophageal squamous cell carcinoma is still controversial. Several studies have reported the feasibility and efficacy of concurrent che...
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Article
Open AccessTIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway
Previous study revealed that the protective effect of TIGAR in cell survival is mediated through the increase in PPP (pentose phosphate pathway) flux. However, it remains unexplored if TIGAR plays an important...
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Article
Open AccessMicroRNA expression profiles predict clinical phenotypes and prognosis in chromophobe renal cell carcinoma
Chromophobe renal cell carcinoma (chRCC) is the third most common subtype of kidney cancers. In the present study, we identified 58 treatment-naïve primary chRCC patients from The Cancer Genome Atlas dataset a...
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Open AccessComparison between 200 mg QD and 100 mg BID oral celecoxib in the treatment of knee or hip osteoarthritis
This network meta-analysis aimed to investigate the effectiveness and safety of 100 mg BID and 200 mg QD oral celecoxib in the treatment of OA of the knee or hip. PubMed, Embase and Cochrane Library were searc...
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Article
Open AccessIdentification of new susceptibility loci for IgA nephropathy in Han Chinese
IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis. Previously identified genome-wide association study (GWAS) loci explain only a fraction of disease risk. To identify novel susceptib...
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Article
The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming
Extensive reprogramming of cellular energy metabolism is a hallmark of cancer. Despite its importance, the molecular mechanism controlling this tumour metabolic shift remains not fully understood. Here we show...
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Article
Open AccessHighlighting Indication of extracorporeal membrane oxygenation in endocrine emergencies
Extracorporeal membrane oxygenation (ECMO) has been repeatedly used to rescue patients with cardiopulmonary arrest. However, its clinical utility in endocrine emergencies remains unclear. Herein, we describe a...
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Open AccessHigher blood hematocrit predicts hyperuricemia: a prospective study of 62897 person-years of follow-up
This prospective study aimed to investigate the relationship between higher hematocrit (Hct) level and hyperuricemia (HU) incidence. A total of 27540 subjects were included. Baseline Hct was classified into fo...
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Open AccessSerum amyloid-beta levels are increased in patients with obstructive sleep apnea syndrome
A critical link between amyloid-beta (Aβ) and hypoxia has been demonstrated in in vitro and animal studies but has not yet been proven in humans. Obstructive sleep apnea syndrome (OSAS) is a common disorder that ...
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Article
Open AccessStem cell transplantation therapy in Parkinson’s disease
Ineffective therapeutic treatments and inadequate repair ability in the central nervous system are disturbing problems for several neurological diseases. Fortunately, the development of clinically applicable p...
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Article
Open AccessCan silicon carbide serve as a saturable absorber for passive mode-locked fiber lasers?
The study presents a novel demonstration of a passively mode-locked erbium-doped fiber laser (EDFL) that is based on a silicon carbide (SixC1−x) saturable absorber. When the C/Si composition ratio is increased to...
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Article
Open AccessEffectiveness and safety of Glucosamine, chondroitin, the two in combination, or celecoxib in the treatment of osteoarthritis of the knee
This study aimed to investigate the effectiveness and safety of glucosamine, chondroitin, the two in combination, or celecoxib in the treatment of knee osteoarthritis (OA). PubMed, Embase and Cochrane Library ...