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Article
Open AccessRadiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8+ T and NK cells
Immunosuppression by the tumor microenvironment is a pivotal factor contributing to tumor progression and immunotherapy resistance. Priming the tumor immune microenvironment (TIME) has emerged as a promising s...
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Article
Preliminary safety analysis for a heavy water-moderated molten salt reactor
The heavy water-moderated molten salt reactor (HWMSR) is a newly proposed reactor concept, in which heavy water is adopted as the moderator and molten salt dissolved with fissile and fertile elements is used a...
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Article
Open AccessAn ultra-short-acting benzodiazepine in thalamic nucleus reuniens undermines fear extinction via intermediation of hippocamposeptal circuits
Benzodiazepines, commonly used for anxiolytics, hinder conditioned fear extinction, and the underlying circuit mechanisms are unclear. Utilizing remimazolam, an ultra-short-acting benzodiazepine, here we revea...
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Article
High-temperature corrosion resistance of Fe–Cr–Mo amorphous coating for water wall protection of USC boiler
A novel Fe–Cr–Mo amorphous coating, a high-temperature corrosion-resistant material for water wall protection of power plant ultra-supercritical boilers, has been prepared via arc spraying. A systematic study ...
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Article
Design and prototy** of the readout electronics for the transition radiation detector in the high energy cosmic radiation detection facility
The high energy cosmic-radiation detection (HERD) facility is planned to launch in 2027 and scheduled to be installed on the China Space Station. It serves as a dark matter particle detector, a cosmic ray inst...
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Article
Supplement to “Effect and Safety of Hydroxysafflor Yellow A for Injection in Patients with Acute Ischemic Stroke of Blood Stasis Syndrome: A Phase II, Multicenter, Randomized, Double-Blind, Multiple-Dose, Active-Controlled Clinical Trial”
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Article
Plutonium utilization in a small modular molten-salt reactor based on a batch fuel reprocessing scheme
A molten salt reactor (MSR) has outstanding features considering the application of thorium fuel, inherent safety, sustainability, and resistance to proliferation. However, fissile material
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Article
Isovector giant dipole resonance mode with an improved propagation approach in the framework of EQMD model
The Extended Quantum Molecular Dynamics (EQMD) model is one of the few QMD-like transport approaches that can describe the \(\alpha \) ...
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Article
Open AccessPropofol improves survival in a murine model of sepsis via inhibiting Rab5a-mediated intracellular trafficking of TLR4
Propofol is a widely used anesthetic and sedative, which has been reported to exert an anti-inflammatory effect. TLR4 plays a critical role in coordinating the immuno-inflammatory response during sepsis. Wheth...
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Article
Open AccessCorrection to: Assembly-level analysis on temperature coefficient of reactivity in a graphite-moderated fuel salt reactor fueled with low-enriched uranium
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Article
Open AccessImmune persistence after different polio sequential immunization schedules in Chinese infants
Trivalent oral poliovirus vaccine (tOPV) has been withdrawn and instead an inactivated poliovirus vaccine (IPV) and bivalent type 1 and type 3 OPV (bOPV) sequential immunization schedule has been implemented s...
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Article
Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n
Nondestructive and noninvasive neutron assays are essential applications of neutron techniques. Neutron resonance transmission analysis (NRTA) is a powerful nondestructive method for investigating the elementa...
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Article
Open AccessAge-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis
Increased oxidative stress contributes to enhanced osteoclastogenesis and age-related bone loss. Melatonin (MT) is an endogenous antioxidant and declines with aging. However, it was unclear whether the decline...
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Article
Fungal diversity notes 1717–1817: taxonomic and phylogenetic contributions on genera and species of fungal taxa
As the continuation of Fungal Diversity Notes series, the current paper is the 16th contribution to this series. A total of 103 taxa from seven classes in Ascomycota and Basidiomycota are included here. Of these ...
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Article
Strength prediction and drillability identification for rock based on measurement while drilling parameters
Rapid acquisition of rock mechanical parameters and accurate identification of rock drillability are important to guide the safe construction of different scale drilling engineering (wells and boreholes) and h...
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Article
A Unified Bayesian Framework for Bi-overlap**-Clustering Multi-omics Data via Sparse Matrix Factorization
The advances of modern sequencing techniques have generated an unprecedented amount of multi-omics data which provide great opportunities to quantitatively explore functional genomes from different but complem...
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Article
Open AccessOral pathogens exacerbate Parkinson’s disease by promoting Th1 cell infiltration in mice
Parkinson’s disease (PD) is a common chronic neurological disorder with a high risk of disability and no cure. Periodontitis is an infectious bacterial disease occurring in periodontal supporting tissues. Stud...
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Article
Concurrent chemoradiotherapy combined with nimotuzumab in stage III–IVa nasopharyngeal carcinoma: a retrospective analysis
The efficacy and safety of nimotuzumab (NTZ) added to concurrent chemoradiotherapy (CCRT) were investigated in patients with stage III–IVa nasopharyngeal carcinoma (NPC).
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Article
Open AccessAssembly-level analysis on temperature coefficient of reactivity in a graphite-moderated fuel salt reactor fueled with low-enriched uranium
To provide a reliable and comprehensive data reference for core geometry design of graphite-moderated and low-enriched uranium fueled molten salt reactors, the influences of geometric parameters on the tempera...
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Article
Occurrence and ecological risk assessment of 16 phthalates in surface water of the mainstream of the Yangtze River, China
Phthalic acid esters (PAEs), a class of typical endocrine disruptors, have received considerable attention due to their widespread applications and adverse effects on biological health. In this study, 30 water...
