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Article
Open AccessMining the interpretable prognostic features from pathological image of intrahepatic cholangiocarcinoma using multi-modal deep learning
The advances in deep learning-based pathological image analysis have invoked tremendous insights into cancer prognostication. Still, lack of interpretability remains a significant barrier to clinical application.
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Article
Open AccessTransfer metric learning: algorithms, applications and outlooks
Distance metric learning (DML) aims to find an appropriate way to reveal the underlying data relationship. It is critical in many machine learning, pattern recognition and data mining algorithms, and usually r...
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Article
Open AccessY4 RNA fragments from cardiosphere-derived cells ameliorate diabetic myocardial ischemia‒reperfusion injury by inhibiting protein kinase C β-mediated macrophage polarization
The specific pathophysiological pathways through which diabetes exacerbates myocardial ischemia/reperfusion (I/R) injury remain unclear; however, dysregulation of immune and inflammatory cells, potentially dri...
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Article
Open AccessDown-regulation of KLRB1 is associated with increased cell growth, metastasis, poor prognosis, as well as a dysfunctional immune microenvironment in LUAD
Killer cell lectin-like receptor B1 (KLRB1) is implicated in cancer progression and immunity. In this study, we aimed to evaluate the expression levels of KLRB1 in lung adenocarcinoma (LUAD) and analyze the re...
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Article
Open AccessMetabolic landscape and pathogenic insights: a comprehensive analysis of high ovarian response in infertile women undergoing in vitro fertilization
In the realm of assisted reproduction, a subset of infertile patients demonstrates high ovarian response following controlled ovarian stimulation (COS), with approximately 29.7% facing the risk of Ovarian Hype...
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Article
Open AccessDistinguishability of binary extreme-mass-ratio inspirals in low frequency band
The inspiral of compact stellar objects into massive black holes are one of the main astrophysical sources for the Laser Interferometer Space Antenna (LISA) and Taiji. These extreme-mass-ratio inspirals (EMRIs...
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Article
Open AccessDraft Genome Sequence of Candida saopaulonensis from a Very Premature Infant with Sepsis
The rare fungus Candida saopaulonensis has never been reported to be associated with human infection. We report the draft genome sequence of the first clinical isolate of C. saopaulonensis, which was isolated fro...
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Article
Open AccessNBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin
Idiopathic pulmonary fibrosis is a persistent disease of the lung interstitium for which there is no efficacious pharmacological therapy. Protodioscin, a steroidal saponin, possesses diverse pharmacological pr...
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Article
Open AccessA radiomics signature derived from CT imaging to predict MSI status and immunotherapy outcomes in gastric cancer: a multi-cohort study
Accurate microsatellite instability (MSI) testing is essential for identifying gastric cancer (GC) patients eligible for immunotherapy. We aimed to develop and validate a CT-based radiomics signature to predic...
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Article
Open AccessGenome assemblies of 11 bamboo species highlight diversification induced by dynamic subgenome dominance
Polyploidy (genome duplication) is a pivotal force in evolution. However, the interactions between parental genomes in a polyploid nucleus, frequently involving subgenome dominance, are poorly understood. Here...
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Open AccessThe molecular characteristics could supplement the staging system of pT2/T3N0M0 esophageal squamous cell carcinoma: a translational study based on a cohort with over 20 years of follow-up
This study aimed to construct a model based on 23 enrolled molecules to evaluate prognoses of pT2/3N0M0 esophageal squamous cell carcinoma (ESCC) patients with up to 20 years of follow-up.
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Article
Open AccessMitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype
Bacterial genotoxins damage host cells by targeting their chromosomal DNA. In the present study, we demonstrate that a genotoxin of Salmonella Typhi, typhoid toxin, triggers the senescence-associated secretory ph...
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Article
Open AccessLactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model
Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate ...
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Article
Open AccessPharmacokinetic and Safety Study of Bismuth Potassium Citrate Formulations in Healthy Subjects
Potassium bismuth citrate is a gastric mucosal protector and a key drug for treating peptic ulcers.
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Article
Open AccessGenetic drivers of heterogeneity in type 2 diabetes pathophysiology
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic c...
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Article
Open AccessChanges in microbial composition and interaction patterns of female urogenital tract and rectum in response to HPV infection
Previous studies have shown that changes in the microbial community of the female urogenital tract are associated with Human papillomavirus (HPV) infection. However, research on this association was mostly foc...
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Article
Open AccessUltracold field-linked tetratomic molecules
Ultracold polyatomic molecules offer opportunities1 in cold chemistry2,3, precision measurements4 and quantum information processing5,6, because of their rich internal structure. However, their increased complexi...
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Article
Open AccessLong-term outcomes of pelvic exenterations for gynecological malignancies: a single-center retrospective cohort study
Recently, with the advancement of medical technology, the postoperative morbidity of pelvic exenteration (PE) has gradually decreased, and it has become a curative treatment option for some patients with recur...
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Article
Open AccessThe association between plasma free amino acids and type 2 diabetes mellitus complicated with infection in Chinese patients
Type 2 diabetes mellitus (T2DM), one of the most common public diseases threatening human health, is always accompanied by infection. Though there are still a variety of flaws in the treatment of some infectio...
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Article
Open AccessIdentification of key genes in chronic intermittent hypoxia-induced lung cancer progression based on transcriptome sequencing
Obstructive sleep apnea (OSA) is associated with increased risk of lung cancer mortality. Nevertheless, little is known about the underlying molecular mechanisms. This research aimed to investigate differentia...
