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  1. Article

    Open Access

    Discovery of a novel EGFR ligand DPBA that degrades EGFR and suppresses EGFR-positive NSCLC growth

    Epidermal growth factor receptor (EGFR) activation plays a pivotal role in EGFR-driven non-small cell lung cancer (NSCLC) and is considered as a key target of molecular targeted therapy. EGFR tyrosine kinase i...

    Nan Yao, Chen-Ran Wang, Ming-Qun Liu in Signal Transduction and Targeted Therapy (2020)

  2. Article

    Open Access

    Treatment of CD20-directed Chimeric Antigen Receptor-modified T cells in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: an early phase IIa trial report

    Patients with relapsed or refractory non-Hodgkin lymphoma have a dismal prognosis. Chimeric Antigen Receptor (CAR)-modified T cells (CART cells) that targeted CD20 were effective in a phase I clinical trial fo...

    Wen-ying Zhang, Yao Wang, Ye-lei Guo in Signal Transduction and Targeted Therapy (2016)