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Article
Open AccessBIND&MODIFY: a long-range method for single-molecule map** of chromatin modifications in eukaryotes
Epigenetic modifications of histones are associated with development and pathogenesis of disease. Existing approaches cannot provide insights into long-range interactions and represent the average chromatin st...
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Article
Open AccessSignaling Mechanism for Modulation by GLP-1 and Exendin-4 of GABA Receptors on Rat Retinal Ganglion Cells
Glucagon-like peptide-1 (GLP-1) is expressed in retinal neurons, but its role in the retina is largely unknown. Here, we demonstrated that GLP-1 or the GLP-1 receptor (GLP-1R; a G protein-coupled receptor) ago...
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Article
Mangiferin Promotes Bregs Level, Activates Nrf2 Antioxidant Signaling, and Inhibits Proinflammatory Cytokine Expression in Murine Splenic Mononuclear Cells In Vitro
Recent studies indicated that regulatory B cells (Bregs) and nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant signaling pathway play important roles in the pathogenesis of chronic graft-versus-ho...
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Article
Open AccessCombinations of single-top-quark production cross-section measurements and |fLVVtb| determinations at \( \sqrt{s} \) = 7 and 8 TeV with the ATLAS and CMS experiments
This paper presents the combinations of single-top-quark production cross-section measurements by the ATLAS and CMS Collaborations, using data from LHC proton-proton collisions at
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Article
Open AccessUp-regulation of SR-BI promotes progression and serves as a prognostic biomarker in clear cell renal cell carcinoma
Scavenger receptor class B type I (SR-BI) has been reported to be involved in carcinogenesis of several human cancers. However, it is currently unknown whether SR-BI plays a role in clear cell renal cell carci...
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Article
A novel learning algorithm of single-hidden-layer feedforward neural networks
Single-hidden-layer feedforward neural network (SLFN) is an effective model for data classification and regression. However, it has a very important defect that it is rather time-consuming to explore the train...
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Article
Open AccessAutophagy Protects against Palmitic Acid-Induced Apoptosis in Podocytes in vitro
Autophagy is a highly conserved degradation process that is involved in the clearance of proteins and damaged organelles to maintain intracellular homeostasis and cell integrity. Type 2 diabetes is often accom...
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Article
Open AccessInhaled nitric oxide and the risk of renal dysfunction in patients with acute respiratory distress syndrome: a propensity-matched cohort study
Inhaled nitric oxide (iNO) is a rescue therapy for severe hypoxemia in patients with acute respiratory distress syndrome (ARDS). Pooled data from clinical trials have signaled a renal safety warning for iNO th...
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Article
Open AccessMeasurements of the Higgs boson production and decay rates and constraints on its couplings from a combined ATLAS and CMS analysis of the LHC pp collision data at \( \sqrt{s}=7 \) and 8 TeV
Combined ATLAS and CMS measurements of the Higgs boson production and decay rates, as well as constraints on its couplings to vector bosons and fermions, are presented. The combination is based on the analysis...
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Article
Open AccessSearch for supersymmetry in the vector-boson fusion topology in proton-proton collisions at \( \sqrt{s}=8 \) TeV
The first search for supersymmetry in the vector-boson fusion topology is presented. The search targets final states with at least two leptons, large missing transverse momentum, and two jets with a large sepa...
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Article
Open AccessRisk factors for Enterobius vermicularis infection in children in Gaozhou, Guangdong, China
Enterobius vermicularis infection is a prevalent intestinal parasitic disease in children. In this study, we explored the epidemiological status and risk factors for E. vermicularis infection i...
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Article
Effect of Huxin Formula (护心方) on reverse cholesterol transport in ApoE-gene knockout mice
To observe the effect of Huxin Formula (护心方, HXF) on expressions of the chief reverse cholesterol transport (RCT) associated genes, caveolin-1 and scavenger receptor-BI (SR-BI) in ApoE-gene knockout [ApoE (−/−...
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Article
Open AccessA highly efficient β-glucosidase from the buffalo rumen fungus Neocallimastix patriciarum W5
Cellulose, which is the most abundant renewable biomass on earth, is a potential bio-resource of alternative energy. The hydrolysis of plant polysaccharides is catalyzed by microbial cellulases, including endo...
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Article
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
Intrinsic resistance to tyrosine kinase inhibitor (TKI) drugs is limiting the progress of targeted cancer therapies. The efficacy of TKIs relies on their inhibition of oncogenic signaling but also on the induc...
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Article
Open AccessDeciphering neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans
Drosophila albomicans is a unique model organism for studying both sex chromosome and B chromosome evolution. A pair of its autosomes comprising roughly 40% of the whole genome has fused to the ancient X and Y ch...
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Article
Open AccessEtiology analysis and computed tomography imaging of a tonsillar inflammatory myofibroblastic tumor: report of an immunocompetent patient and brief review
The etiology of Inflammatory myofibroblastic tumor(IMT) is contentious. In this study, we used computed tomography (CT) to examine tonsillar IMT and further analyzed the etiology of this entity.
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Article
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2
Dai Zhang and colleagues report a genome-wide association study for schizophrenia in the Han Chinese population. They identify a new susceptibility locus at 11p11.2 and also identify a locus at 6p21-22.1 in th...
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Article
Open AccessFunctional characterization of cellulases identified from the cow rumen fungus Neocallimastix patriciarum W5 by transcriptomic and secretomic analyses
Neocallimastix patriciarum is one of the common anaerobic fungi in the digestive tracts of ruminants that can actively digest cellulosic materials, and its cellulases have great potential for hydrolyzing cellulos...
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Article
Expressions of three cotton genes encoding the PIP proteins are regulated in root development and in response to stresses
Cotton (Gossypium hirsutum), the most important textile crop worldwide, often encounters water stress such as drought or waterlog during its growth season (Summer). To investigate molecular mechanism of water reg...
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Article
Male transsexualism in mainland China
Though there have been many studies about transsexualism in the West, as well as other parts of the world, nothing has been reported for mainland China. This is mainly because communication about any sexual ph...
