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335 Result(s)
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**ang-Liang Chen
Life Sciences
English
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Article
Open AccessThe influence of sex-specific factors on biological transformations and health outcomes in aging processes
The aging process demonstrates notable differences between males and females, which are key factors in disease susceptibility and lifespan. The differences in sex chromosomes are fundamental to the presence of...
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Article
CRISPR-array-mediated imaging of non-repetitive and multiplex genomic loci in living cells
Dynamic imaging of genomic loci is key for understanding gene regulation, but methods for imaging genomes, in particular non-repetitive DNAs, are limited. We developed CRISPRdelight, a DNA-labeling system base...
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Article
Disrupting CCDC137-mediated LZTS2 and β-TrCP interaction in the nucleus inhibits hepatocellular carcinoma development via β-catenin and AKT
Hepatocellular carcinoma (HCC) is a highly heterogeneous solid tumor, with its biological characteristics intricately linked to the activation of oncogenes. This research specifically explored CCDC137, a molec...
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Article
Identifying modifiable factors and their joint effect on brain health: an exposome-wide association study
Considerable uncertainty remains regarding the associations of multiple factors with brain health. We aimed to conduct an exposome-wide association study on neurodegenerative disease and neuropsychiatry disord...
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Article
Differentiation of bone marrow mesenchymal stem cells into Leydig-like cells with testicular extract liquid in vitro
Differentiation of Leydig cells plays a key role in male reproductive function. Bone marrow mesenchymal stem cells (BMSCs) have emerged as a potential cell source for generating Leydig-like cells due to their ...
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Article
Open AccessMed1 inhibits ferroptosis and alleviates liver injury in acute liver failure via Nrf2 activation
Extensive hepatocyte mortality and the absence of specific medical therapy significantly contribute to the unfavorable prognosis of acute liver failure (ALF). Ferroptosis is a crucial form of cell death involv...
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Article
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
The conversion of phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 3,4,5-triphosphate by phosphoinositide 3-kinase γ (PI3Kγ) is critical for neutrophil chemotaxis and cancer metastasis. PI3Kγ is a...
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Article
Structure and assembly of the α-carboxysome in the marine cyanobacterium Prochlorococcus
Carboxysomes are bacterial microcompartments that encapsulate the enzymes RuBisCO and carbonic anhydrase in a proteinaceous shell to enhance the efficiency of photosynthetic carbon fixation. The self-assembly ...
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Article
Open AccessSugarcane borers: species, distribution, damage and management options
Lepidopteran borers stand out as the most destructive pests in sugarcane, leading to reductions in stalk weight, juice quality and sugar recovery. Presently, integrated pest management (IPM) systems are utiliz...
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Article
Open AccessA small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models
Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at the clinical level. ...
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Article
Improving growth, omega-3 contents, and disease resistance of Asian seabass: status of a 20-year family-based breeding program
Aquaculture has been one of the fastest-growing sectors in agriculture and plays an important role in supplying high quality proteins for humans. Genetic improvement for important traits is essential for incre...
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Article
Open AccessLessons learned: establishing a CLIA-equivalent laboratory for targeted mass spectrometry assays – navigating the transition from research to clinical practice
Mass spectrometry (MS) assays offer exceptional capabilities in high multiplexity, specificity, and throughput. As proteomics technologies continue advancements to identify new disease biomarkers, transition o...
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Article
DNA loo** mediates cooperative transcription activation
Transcription factors respond to multilevel stimuli and co-occupy promoter regions of target genes to activate RNA polymerase (RNAP) in a cooperative manner. To decipher the molecular mechanism, here we report...
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Book
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Article
Open AccessSequencing by avidity enables high accuracy with low reagent consumption
We present avidity sequencing, a sequencing chemistry that separately optimizes the processes of step** along a DNA template and that of identifying each nucleotide within the template. Nucleotide identifica...
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Article
Open AccessTwnbiome: a public database of the healthy Taiwanese gut microbiome
With new advances in next generation sequencing (NGS) technology at reduced costs, research on bacterial genomes in the environment has become affordable. Compared to traditional methods, NGS provides high-thr...
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Article
Dietary supplementation of pyridoxine can enhance the growth performance and improve the protein, lipid utilization efficiency of mandarin fish (Siniperca chuatsi)
This study aimed to assess the effect of pyridoxine supplementation in the mandarin fish diet on growth performance, protein and lipid metabolism, and liver and intestinal histology. Mandarin fish were fed six...
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Article
Tree species mixture effect on extracellular enzyme kinetics varies with enzyme type and soil depth in subtropical plantations
Tree species mixing is an essential measure used to increase soil carbon (C) sinks and enhance nutrient cycling, while enzyme catalysis is the rate-limiting step of soil C mineralization and nutrient release. ...
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Article
Open AccessCREaTor: zero-shot cis-regulatory pattern modeling with attention mechanisms
Linking cis-regulatory sequences to target genes has been a long-standing challenge. In this study, we introduce CREaTor, an attention-based deep neural network designed to model cis-regulatory patterns for genom...
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Article
Open AccessStudying plant autophagy: challenges and recommended methodologies
In plants, autophagy is a conserved process by which intracellular materials, including damaged proteins, aggregates, and entire organelles, are trafficked to the vacuole for degradation, thus maintaining cell...
