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STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion

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  1. Article

    Open Access

    Intrinsic and extrinsic actions of human neural progenitors with SUFU inhibition promote tissue repair and functional recovery from severe spinal cord injury

    Neural progenitor cells (NPCs) derived from human pluripotent stem cells(hPSCs) provide major cell sources for repairing damaged neural circuitry and enabling axonal regeneration after spinal cord injury (SCI)...

    Yong-Long Chen, **ang-Lan Feng, Kin-Wai Tam, Chao-Yang Fan… in npj Regenerative Medicine (2024)

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  2. Article

    20C, a bibenzyl compound isolated from Gastrodia elata, protects PC12 cells against rotenone-induced apoptosis via activation of the Nrf2/ARE/HO-1 signaling pathway

    Our preliminary study shows that a bibenzyl compound isolated from Gastrodia elata, 2-[4-hydroxy-3-(4-hydroxybenzyl)benzyl]-4-(4-hydroxybenzyl)phenol (designated 20C), protects PC12 cells against H2O2-induced inj...

    Ju-yang Huang, Yu-he Yuan, Jia-qing Yan, Ya-nan Wang… in Acta Pharmacologica Sinica (2016)

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  3. Article

    Isoflavones and phytosterols contained in Xuezhikang capsules modulate cholesterol homeostasis in high-fat diet mice

    Xuezhikang (XZK), an extract of red yeast rice, has been widely used in traditional Chinese medicine to treat cardiovascular disease. Three fractions F1, F2 and F3 (primarily containing isoflavones, monacolins...

    Dong Feng, Jian-guo Sun, Run-bin Sun, Bing-chen Ou-Yang… in Acta Pharmacologica Sinica (2015)

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  4. Article

    2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice

    Sterol-regulatory element binding proteins (SREBPs) are major transcription factors that regulate liver lipid biosynthesis. In this article we reported a novel synthetic compound 2-(3-benzoylthioureido)-4,5,6,...

    ** Zhang, Li-na Zhang, Dong-mei Chen, Yan-yun Fu, Feng Zhang… in Acta Pharmacologica Sinica (2015)

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  5. Article

    Vam3, a resveratrol dimer, inhibits cigarette smoke-induced cell apoptosis in lungs by improving mitochondrial function

    To investigate the effects of Vam3 (a resveratrol dimer extracted from Vitis amurensis Rupr) on cigarette smoke (CS)-induced cell apoptosis in lungs in vitro and in vivo and the underlying mechanisms of action.

    Ling-ling Xuan, Ji Shi, Chun-suo Yao, **-ye Bai, Feng Qu… in Acta Pharmacologica Sinica (2014)

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  6. Article

    Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation

    To investigate the action of isothiafludine (NZ-4), a derivative of bis-heterocycle tandem pairs from the natural product leucamide A, on the replication cycle of hepatitis B virus (HBV) in vitro and in vivo.

    Li Yang, Li-** Shi, Hai-jun Chen, **an-Kun Tong… in Acta Pharmacologica Sinica (2014)

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  7. Article

    Norisoboldine alleviates joint destruction in rats with adjuvant-induced arthritis by reducing RANKL, IL-6, PGE2, and MMP-13 expression

    To explore the effects of norisoboldine (NOR), a major isoquinoline alkaloid in Radix Linderae, on joint destruction in rats with adjuvant-induced arthritis (AIA) and its underlying mechanisms.

    Zhi-feng Wei, **ao-lan Jiao, Ting Wang, Qian Lu, Yu-feng **a… in Acta Pharmacologica Sinica (2013)

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  8. Article

    Role of arachidonic acid in hyposmotic membrane stretch-induced increase in calcium-activated potassium currents in gastric myocytes

    To study effects of arachidonic acid (AA) and its metabolites on the hyposmotic membrane stretch-induced increase in calcium-activated potassium currents (IKCa) in gastric myocytes.

    Meng Yang, **ng-lan Li, Hui-ying Xu, Jia-bin Sun, Bin Mei… in Acta Pharmacologica Sinica (2005)

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