25 Result(s)
within
Allergology
Immunology
**ang-Hui **e
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Article
Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells
Interleukin 23 (IL-23) is a new member of the IL-12 family that plays a critical role in promoting the proliferation of memory T helper 1 cells. The heterodimerized IL-23 receptor is composed of a shared IL-12...
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Article
Suppressive effect of Elf-1 on FcεRI α-chain expression in primary mast cells
The high-affinity receptor for immunoglobulin E (IgE), FcεRI, is specifically expressed in mast cells and basophils and plays a key role in IgE-mediated allergic reactions. The transcription factor Elf-1 has b...
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Article
FcεRIα gene –18483A>C polymorphism affects transcriptional activity through YY1 binding
Three frequent genetic polymorphisms in the human high-affinity IgE receptor α-subunit (FcεRIα) were shown to be associated with allergic disorders and/or total serum IgE levels in allergic patients. Two of th...
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Article
Open AccessAdaptor protein Shc acts as an immune-regulator for the LPS-stimulated maturation of bone marrow-derived dendritic cells
The Shc isoforms is known to mediate immune responses and has been indicated as a negative regulator of autoimmunity and lymphocyte activation. We aimed to evaluate the immune-regulatory role of Shc in rat bon...
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Article
Open AccessInfluence of variable domain glycosylation on anti-neutrophil cytoplasmic autoantibodies and anti-glomerular basement membrane autoantibodies
The pathophysiological significance of variable region glycosylation of autoantibodies is still unclear. In the current study, the influence of the variable region N-linked oligosaccharides on the reactivity o...
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Article
Increased Th17 cell frequency concomitant with decreased Foxp3+ Treg cell frequency in the peripheral circulation of patients with carotid artery plaques
We investigated a possible imbalance between T helper (Th)17 and CD4+ CD25+ forkhead/winged helix transcription factor (Foxp3) T regulatory (Treg) cells in patients with carotid artery plaques.
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Article
The TRIMCyp genotype in four species of macaques in China
The tripartite motif protein (TRIM)5α/CypA fusion protein TRIMCyp in Old World monkeys is generally considered unable to restrict HIV-1 replication. Monkeys with TRIMCyp can serve as a unique animal model for ...
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Article
Open AccessMechanisims of asthma and allergic disease – 1071. Chemokines from cord blood mononuclear cells and the development of eczema or wheeze at 2 years of age in infants at high risk for atopy
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Open AccessThe distribution of IgG subclass deposition on renal tissues from patients with anti-glomerular basement membrane disease
Renal injury of anti-glomerular basement membrane (GBM) disease is defined by the linear deposition of IgG along GBM and rapidly progressive glomerulonephritis. To date, the distribution of anti-GBM IgG subcla...
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Article
Open AccessGlomerular C1q deposition and serum anti-C1q antibodies in anti-glomerular basement membrane disease
Anti-glomerular basement membrane (GBM) disease is a well-known antibody-induced autoimmune disease. A few patients have glomerular C1q deposition, but it is usually absent on renal histopathology. The role of...
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Article
ACE2 and Ang-(1–7) protect endothelial cell function and prevent early atherosclerosis by inhibiting inflammatory response
Angiotensin-converting enzyme 2 (ACE2) is a counter-regulator against ACE by converting angiotensin II (Ang-II) to Ang-(1–7), but the effect of ACE2 and Ang-(1–7) on endothelial cell function and atherosclerot...
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Open AccessProtective effects of thalidomide on pulmonary injuries in a rat model of paraquat intoxication
This study was designed to evaluate the protective effects of thalidomide on paraquat (PQ)-induced lung injuries in a rat model and to explore the underlying mechanisms.
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Article
Open Accessβ-Catenin is required for the differentiation of iNKT2 and iNKT17 cells that augment IL-25-dependent lung inflammation
Invariant Natural Killer T (iNKT) cells have been implicated in lung inflammation in humans and also shown to be a key cell type in inducing allergic lung inflammation in mouse models. iNKT cells differentiate...
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Article
Open AccessXXIV World Allergy Congress 2015
A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts
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Article
Open Access7th Drug hypersensitivity meeting: part two
Poster walk 11: miscellaneous drug hypersensitivity 2 (P92–P94, P96–P101)
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Article
Open AccessWAO International Scientific Conference (WISC 2016) Abstracts
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Article
Anti-glomerular basement membrane glomerulonephritis with thrombotic microangiopathy: a case report
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Article
Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages
Gout, the most prevalent inflammatory arthritis worldwide, released interleukin-1β (IL-1β) and Cathepsin B inflammatory mediators that constitute the hallmark of the disease. Herein we aimed to investigate whe...
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Article
COVID-19 illness and autoimmune diseases: recent insights
The aim of this review is to explore whether patients with autoimmune diseases (AIDs) were at high risk of infection during the COVID-19 epidemic and how severe acute respiratory syndrome coronavirus 2 (SARS-C...
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Article
Clinical Manifestations of Pediatric Food Allergy: a Contemporary Review
Food allergies (FAs) are an emerging health care issue, and a “second wave of the allergy epidemic” was named. There are extensive data that documented the prevalence rate as high as approximately 10%. FAs are...
