78 Result(s)
-
Article
Comparative single-cell transcriptomic profile of hybrid immunity induced by adenovirus vector-based COVID-19 vaccines
In this study, antibody response and a single-cell RNA-seq analysis were conducted on peripheral blood mononuclear cells from five different groups: naïve subjects vaccinated with AZD1222 (AZ) or Ad5-nCoV (Cso...
-
Article
Biochemical and Transcriptome Analysis Reveals Pigment Biosynthesis Influenced Chlorina Leaf Formation in Anoectochilus roxburghii (Wall.) Lindl
Anoectochilus roxburghii (Wall.) Lindl is a perennial herb of the Orchidaceae family; a yellow–green mutant and a yellow mutant were obtained from the wild type, thereby providing good material for the study of l...
-
Article
Bioinformatics Analysis and Experimental Validation of Differential Genes and Pathways in Bone Nonunions
Non-union fractures pose a significant clinical challenge, often leading to prolonged pain and disability. Understanding the molecular mechanisms underlying non-union fractures is crucial for develo** effect...
-
Article
Multimodal Omics Approaches to Aging and Age-Related Diseases
Aging is associated with a progressive decline in physiological capacities and an increased risk of aging-associated disorders. An increasing body of experimental evidence shows that aging is a complex biologi...
-
Chapter
Ring Chromosome 15
Ring chromosome 15 (RC15) can be detected using cell-based karyoty** and fluorescence in situ hybridization (FISH) test to determine its structure and dynamic mosaicism and further characterized by DNA-based...
-
Article
Open AccessAuthor Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
-
Article
Open AccessCCNB1 is a novel prognostic biomarker and promotes proliferation, migration and invasion in Wilms tumor
Wilms tumour (WT) is a mixed type of embryonal tumour that usually occurs in early childhood. However, our knowledge of the pathogenesis or progression mechanism of WT is inadequate, and there is a scarcity of...
-
Article
Open AccessClinical diagnosis of genetic disorders at both single-nucleotide and chromosomal levels based on BGISEQ-500 platform
Most variations in the human genome refer to single-nucleotide variation (SNV), small fragment insertions and deletions, and genomic copy number variation (CNV). Many human diseases including genetic disorders...
-
Article
Open AccessFamilial 5.29 Mb deletion in chromosome Xq22.1–q22.3 with a normal phenotype: a rare pedigree and literature review
Xq22.1–q22.3 deletion is a rare chromosome aberration. The purpose of this study was to identify the correlation between the phenotype and genotype of chromosome Xq22.1–q22.3 deletions.
-
Article
Open AccessRole of muscle FOXO gene in exercise against the skeletal muscle and cardiac age-related defects and mortality caused by high-salt intake in Drosophila
FOXO has long been associated with aging, exercise, and tissue homeostasis, but it remains unclear what the role is of the muscle FOXO gene in E against high-salt intake(HSI)-induced age-related defects of the...
-
Article
Open AccessMulti-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising ...
-
Chapter
Personalized Immuno-Oncology with Immunodeficiency Mouse Models
In the past decades, cancer therapies are evolved from a non-specific approach to a precise and accurate therapy. Precision (or personalized) cancer therapy, in which a patient’s own tumor information is used ...
-
Article
Open AccessGenome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a m...
-
Article
Open AccessCRNDE acts as an epigenetic modulator of the p300/YY1 complex to promote HCC progression and therapeutic resistance
Hepatocellular carcinoma (HCC) is one of the most common primary liver malignancies worldwide. The long-term prognosis for HCC remains extremely poor, with drug resistance being the major underlying cause of r...
-
Article
Open AccessPrognostic signature of esophageal adenocarcinoma based on pyroptosis-related genes
The role of pyroptosis-related genes (PRGs) in esophageal adenocarcinoma (EAC) remains unknown.
-
Article
Author Correction: Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice
-
Article
Open AccessThe genomic architecture of EBV and infected gastric tissue from precursor lesions to carcinoma
Epstein-Barr virus (EBV)-associated gastric carcinomas (EBVaGCs) present unique molecular signatures, but the tumorigenesis of EBVaGCs and the role EBV plays during this process remain poorly understood.
-
Article
Ghrelin Affects Gastric Cancer Progression by Activating AMPK Signaling Pathway
As the endogenous ligand for the GH secretagogue receptor (GHSR), Ghrelin is aberrant expressed in multiple malignant carcinoma, and involved in regulating a number of progression of cancer, especially in meta...
-
Article
miR-23b Attenuates LPS-Induced Inflammatory Responses in Acute Lung Injury via Inhibition of HDAC2
Inflammatory responses play significant role in infectious etiology-induced acute lung injury (ALI). Histone deacetylase 2 is found to be essential and stimulated in lipopolysaccharide (LPS)-induced ALI by reg...
-
Article
Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice
Spleen tyrosine kinase (SYK) is a critical immune signaling molecule and therapeutic target. We identified damaging monoallelic SYK variants in six patients with immune deficiency, multi-organ inflammatory diseas...
