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Chapter
Personalized Immuno-Oncology with Immunodeficiency Mouse Models
In the past decades, cancer therapies are evolved from a non-specific approach to a precise and accurate therapy. Precision (or personalized) cancer therapy, in which a patient’s own tumor information is used ...
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Article
Involvement of acid-sensing ion channel 1a in matrix metabolism of endplate chondrocytes under extracellular acidic conditions through NF-κB transcriptional activity
Acidic conditions are present in degenerated intervertebral discs and are believed to be responsible for matrix breakdown. Acid-sensing ion channel 1a (ASIC1a) is expressed in endplate chondrocytes, and its ac...
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Article
Lipopolysaccharide pretreatment protects against ischemia/reperfusion injury via increase of HSP70 and inhibition of NF-κB
It has been reported that pretreatment of rats with lipopolysaccharide (LPS) increases myocardial functional recovery in ischemia/reperfusion (I/R) hearts. However, the mechanisms by which LPS induces cardiopr...