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  1. No Access

    Chapter

    Personalized Immuno-Oncology with Immunodeficiency Mouse Models

    In the past decades, cancer therapies are evolved from a non-specific approach to a precise and accurate therapy. Precision (or personalized) cancer therapy, in which a patient’s own tumor information is used ...

    Jui-Ling Wang, Wen-Hui Ma, Tak-Wah Wong… in Cancer Research: An Interdisciplinary Appr… (2023)

  2. No Access

    Article

    Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice

    Major depressive disorder is characterized by the deficiencies of monoamine neurotransmitters, neurotrophic factors and persistent neuroinflammation. Microglial activation has been associated with neuroinflamm...

    Qing Liu, Man-Man Zhang, Min-**a Guo, Qiu-** Zhang… in Journal of Neuroimmune Pharmacology (2022)

  3. No Access

    Article

    AAV-Vectored Fms-Related Tyrosine Kinase 3 Ligand Inhibits CD34+ Progenitor Cell Engraftment in Humanized Mice

    Humanized mice have become useful animal models for HIV/AIDS. Since NOD.Cg-Prkdc scid Il2rgtm1Wjl/SzJ (NSG) mice allow the engraftment of primary human immune cells, we aim to determine the role of human Fms-r...

    Lijun Ling, **an Tang, **uyan Huang, **g**g Li… in Journal of Neuroimmune Pharmacology (2018)

  4. No Access

    Article

    Brain Invasion by CD4+ T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice

    Human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) is one of the common causes of cognitive dysfunction and morbidity among infected patients. However, to date, it remains unknown if ...

    **lin Wu, Li Liu, Ka-wai Cheung, Hui Wang… in Journal of Neuroimmune Pharmacology (2016)

  5. No Access

    Article

    Involvement of acid-sensing ion channel 1a in matrix metabolism of endplate chondrocytes under extracellular acidic conditions through NF-κB transcriptional activity

    Acidic conditions are present in degenerated intervertebral discs and are believed to be responsible for matrix breakdown. Acid-sensing ion channel 1a (ASIC1a) is expressed in endplate chondrocytes, and its ac...

    Feng-Lai Yuan, Ming-Dong Zhao, Dong-Lin Jiang, Cheng **… in Cell Stress and Chaperones (2016)

  6. No Access

    Article

    The TRIMCyp genotype in four species of macaques in China

    The tripartite motif protein (TRIM)5α/CypA fusion protein TRIMCyp in Old World monkeys is generally considered unable to restrict HIV-1 replication. Monkeys with TRIMCyp can serve as a unique animal model for ...

    Chang-Qing Yu, Lei Na, **ao-Ling Lv, Jian-Dong Liu, **ao-Ming Liu… in Immunogenetics (2013)

  7. No Access

    Article

    Lipopolysaccharide pretreatment protects against ischemia/reperfusion injury via increase of HSP70 and inhibition of NF-κB

    It has been reported that pretreatment of rats with lipopolysaccharide (LPS) increases myocardial functional recovery in ischemia/reperfusion (I/R) hearts. However, the mechanisms by which LPS induces cardiopr...

    Yong-wei Yao, Guo-hui Zhang, Ying-yu Zhang, Wei-dong Li… in Cell Stress and Chaperones (2011)

  8. No Access

    Article

    FcεRIα gene –18483A>C polymorphism affects transcriptional activity through YY1 binding

    Three frequent genetic polymorphisms in the human high-affinity IgE receptor α-subunit (FcεRIα) were shown to be associated with allergic disorders and/or total serum IgE levels in allergic patients. Two of th...

    Daniel P. Potaczek, Keiko Maeda, Qing-Hui Wang, Nobuhiro Nakano… in Immunogenetics (2009)

  9. No Access

    Article

    Suppressive effect of Elf-1 on FcεRI α-chain expression in primary mast cells

    The high-affinity receptor for immunoglobulin E (IgE), FcεRI, is specifically expressed in mast cells and basophils and plays a key role in IgE-mediated allergic reactions. The transcription factor Elf-1 has b...

    Qing-hui Wang, Chiharu Nishiyama, Nobuhiro Nakano, Naomi Shimokawa… in Immunogenetics (2008)

  10. No Access

    Article

    Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells

    Interleukin 23 (IL-23) is a new member of the IL-12 family that plays a critical role in promoting the proliferation of memory T helper 1 cells. The heterodimerized IL-23 receptor is composed of a shared IL-12...

    **ang-Yue Zhang, Hai-**g Zhang, Yun Zhang, Ying-Jie Fu, Jie He… in Immunogenetics (2006)