![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Structural basis for substrate binding, cleavage and allostery in the tRNA maturase RNase Z
Transfer RNAs (tRNAs) are synthesized as part of longer primary transcripts that require processing of both their 3′ and 5′ extremities in every living organism known. The 5′ side is processed (matured) by the...
-
Article
Open AccessAnalyses of pig genomes provide insight into porcine demography and evolution
For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and...
-
Article
Open AccessLight Manipulation for Organic Optoelectronics Using Bio-inspired Moth's Eye Nanostructures
Organic-based optoelectronic devices, including light-emitting diodes (OLEDs) and solar cells (OSCs) hold great promise as low-cost and large-area electro-optical devices and renewable energy sources. However,...
-
Article
Open AccessExtreme violation of local realism with a hyper-entangled four-photon-eight-qubit Greenberger-Horne-Zelinger state
The highest qubit Ardehali inequality violation with 203 standard deviations is first experimentally demonstrated using the hyper-entangled four-photon-eight-qubit Greenberger-Horne-Zeilinger (GHZ) state. More...
-
Article
Open AccessSolvent induced rapid modulation of micro/nano structures of metal carboxylates coordination polymers: mechanism and morphology dependent magnetism
Rational modulation of morphology is very important for functional coordination polymers (CPs) micro/nanostructures and new strategies are still desired to achieve this challenging target. Herein, organic solv...
-
Article
Open AccessThe fate of recent duplicated genes following a fourth-round whole genome duplication in a tetraploid fish, common carp (Cyprinus carpio)
Whole genome duplication (WGD) results in extensive genetic redundancy. In plants and yeast, WGD is followed by rapid gene deletions and intense expression differentiation with slow functional divergence. Howe...
-
Article
Open AccessMulti-frequency complex network from time series for uncovering oil-water flow structure
Uncovering complex oil-water flow structure represents a challenge in diverse scientific disciplines. This challenge stimulates us to develop a new distributed conductance sensor for measuring local flow signa...
-
Article
The paraventricular thalamus controls a central amygdala fear circuit
Inhibiting projections from the paraventricular nucleus of the thalamus to a specific division of the amygdala prevents fear conditioning in mice, indicating an important role for the thalamus–amygdala circuit...
-
Article
Open AccessAmniotic fluid stem cells provide considerable advantages in epidermal regeneration: B7H4 creates a moderate inflammation microenvironment to promote wound repair
The current treatments for severe skin injury all involve skin grafting. However, there is a worldwide shortage of donor skin tissue. In this study, we examined the advantages of using human amniotic fluid ste...
-
Article
Open AccessEffects of Nt-truncation and coexpression of isolated Nt domains on the membrane trafficking of electroneutral Na+/HCO3– cotransporters
The SLC4 genes are all capable of producing multiple variants by alternative splicing or using alternative promoters. The physiological consequences of such diversity are of great interest to investigators. He...
-
Article
Open AccessStorage of multiple single-photon pulses emitted from a quantum dot in a solid-state quantum memory
Quantum repeaters are critical components for distributing entanglement over long distances in presence of unavoidable optical losses during transmission. Stimulated by the Duan–Lukin–Cirac–Zoller protocol, ma...
-
Article
Open AccessFocal Lesions in Fatty Liver: If Quantitative Analysis Facilitates the Differentiation of Atypical Benign from Malignant Lesions
To evaluate the diagnostic performance of quantitative analysis as an adjunctive diagnostic tool to contrast-enhanced ultrasound (US) for the differentiation of atypical benign focal liver lesions (FLLs) from ...
-
Article
Open AccessSubstituent Effects on the Photodeprotection Reactions of Selected Ketoprofen Derivatives in Phosphate Buffered Aqueous Solutions
Photodeprotection is an important reaction that has been attracting broad interest for use in a variety of applications. Recent advances in ultrafast and vibrational time-resolved spectroscopies can facilitate...
-
Article
Open AccessExperimental investigation of the information entropic Bell inequality
Inequalities of information entropic play a fundamental role in information theory and have been employed effectively in finding bounds on optimal rates of various information-processing tasks. In this paper, ...
-
Article
The crystal structure of Cpf1 in complex with CRISPR RNA
The crystal structure of monomeric Lachnospiraceae bacterium Cpf1 protein bound to CRISPR RNA is presented, establishing a framework for engineering LbCpf1 to improve its efficiency and specificity for genome edi...
-
Article
Open AccessExperimental Demonstration of a Hybrid-Quantum-Emitter Producing Individual Entangled Photon Pairs in the Telecom Band
Quantum emitters generating individual entangled photon pairs (IEPP) have significant fundamental advantages over schemes that suffer from multiple photon emission, or schemes that require post-selection techn...
-
Article
Open AccessOrexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man
Orexin neuropeptides regulate sleep/wake through orexin receptors (OX1R, OX2R); OX2R is the predominant mediator of arousal promotion. The potential for single OX2R antagonism to effectively promote sleep has yet...
-
Article
Open AccessHepatocellular adenoma: comparison between real-time contrast-enhanced ultrasound and dynamic computed tomography
To investigate and compare the contrast-enhanced ultrasound (CEUS) features of histologically proven HCA with those of contrast-enhanced computed tomography (CECT).
-
Article
Open AccessThe effectiveness of pressure therapy (15–25 mmHg) for hypertrophic burn scars: A systematic review and meta-analysis
Although pressure therapy (PT) represents the standard care for prevention and treatment of hypertrophic scar (HS) from burns, its practice is largely based on empirical evidence and its effectiveness remains ...
-
Article
Open AccessHigh expression of AKR1B10 predicts low risk of early tumor recurrence in patients with hepatitis B virus-related hepatocellular carcinoma
To clarify the relationship between aldo-keto reductase family 1 member B10 (AKR1B10) expression and early hepatocellular carcinoma (HCC) recurrence, this study detected AKR1B10 expression in tumor and adjacen...