15 Result(s)
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Open AccessMetabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder
Classical metabolomic and new metabolic network methods were used to study the developmental features of autism spectrum disorder (ASD) in newborns (n = 205) and 5-year-old children (n = 53). Eighty percent of th...
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Open AccessComparative and phylogenetic analysis of Chiloschista (Orchidaceae) species and DNA barcoding investigation based on plastid genomes
Chiloschista (Orchidaceae, Aeridinae) is an epiphytic leafless orchid that is mainly distributed in tropical or subtropical forest canopies. This rare and threatened orchid lacks molecular resources for phylogene...
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Open AccessGeneration of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor
The α7 nicotinic acetylcholine receptor (nAChR), a potential drug target for treating cognitive disorders, mediates communication between neuronal and non-neuronal cells. Although many competitive antagonists,...
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Open AccessA proteome-scale map of the SARS-CoV-2–human contactome
Understanding the mechanisms of coronavirus disease 2019 (COVID-19) disease severity to efficiently design therapies for emerging virus variants remains an urgent challenge of the ongoing pandemic. Infection a...
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Open AccessModulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140
SP140 is a bromodomain-containing protein expressed predominantly in immune cells. Genetic polymorphisms and epigenetic modifications in the SP140 locus have been linked to Crohn’s disease (CD), suggesting a role...
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Open AccessGenomes of leafy and leafless Platanthera orchids illuminate the evolution of mycoheterotrophy
To improve our understanding of the origin and evolution of mycoheterotrophic plants, we here present the chromosome-scale genome assemblies of two sibling orchid species: partially mycoheterotrophic Platanthera ...
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Open AccessT cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
Unlike chimeric antigen receptors, T-cell receptors (TCRs) can recognize intracellular targets presented on human leukocyte antigen (HLA) molecules. Here we demonstrate that T cells expressing TCRs specific fo...
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Open AccessWolfberry genomes and the evolution of Lycium (Solanaceae)
Wolfberry Lycium, an economically important genus of the Solanaceae family, contains approximately 80 species and shows a fragmented distribution pattern among the Northern and Southern Hemispheres. Although seve...
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Open AccessRoadmap for naming uncultivated Archaea and Bacteria
The assembly of single-amplified genomes (SAGs) and metagenome-assembled genomes (MAGs) has led to a surge in genome-based discoveries of members affiliated with Archaea and Bacteria, bringing with it a need t...
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Structural basis for human coronavirus attachment to sialic acid receptors
Coronaviruses cause respiratory tract infections in humans and outbreaks of deadly pneumonia worldwide. Infections are initiated by the transmembrane spike (S) glycoprotein, which binds to host receptors and f...
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Correction to: A new species of Microterys (Hymenoptera: Encyrtidae) from Northeast China, parasitoid of Parthenolecanium corni (Bouché) (Hemiptera: Coccidae)
Correction: In a paper describing Microterys angustus Zu, Li & Wang sp. nov. (Zu et al., 2018), the authors omitted to designate the depository of the holotype.
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Correction to: A new species of Anagyrus (Hymenoptera: Encyrtidae) from China, parasitoid of Phenacoccus solani Ferris (Hemiptera: Pseudococcidae) on Lycoris radiata (L’Her.) Herb.
The published online article unfortunately has an error. In a paper describing Anagyrus pseudofuscus Zu sp. nov. (Zu et al. 2018), the authors omitted to designate the depository of the holotype.
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Article
Open AccessG9A promotes gastric cancer metastasis by upregulating ITGB3 in a SET domain-independent manner
Tumor metastasis is the leading cause of death in patients with advanced gastric cancer (GC). Limited therapeutic regimens are available for this condition, which is associated with a poor prognosis, and the m...
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Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3
Strigolactones (SLs) are endogenous hormones and exuded signaling molecules in plant responses to low levels of mineral nutrients. Key mediators of the SL signaling pathway in rice include the α/β-fold hydrola...
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Open AccessGeneration and analysis of expressed sequence tags from the ciliate protozoan parasite Ichthyophthirius multifiliis
The ciliate protozoan Ichthyophthirius multifiliis (Ich) is an important parasite of freshwater fish that causes 'white spot disease' leading to significant losses. A genomic resource for large-scale studies of t...
