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20,737 Result(s)
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Free Amino-acids of Isolated Calf Thymus Nuclei
CALF thymus nuclei prepared by the sucrose–calcium chloride method of Allfrey et al.1 are remarkably biochemically active, as judged by the incorporation of labelled amino-acids into the nuclear proteins1,2. Such...
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Breakdown Rate of Serum 7S γ-Globulins in Mice
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Polyamide Layer Chromatography of some Synthetic Food Colours
RECENT developments in the preparation, of polyamide layers in our laboratory have facilitated the application of polyamide layer chromatography to many kinds of compounds besides phenolic compounds; for examp...
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Structure, sequence and expression of the hepatitis delta (δ) viral genome
Nature 323, 508–514 (1986). A GUANOSINE residue was omitted from the nucleotide sequence of the hepatitis 8 viral (HDV) genomic RNA between residues 1,113 and 1,114 (Figs 4 and 5). HDV RNA therefore consists o...
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Plight of Wei **gsheng
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Straight talking
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Non-haemolytic β-amino-acid oligomers
Pathogenic bacteria are becoming increasingly resistant to common antibiotics, stimulating an intensive search for new ones. Knowing that a class of medium-sized peptides (magainins1) are widely used by host orga...
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Correction: The limits of selection during maize domestication
Nature 398 , 236 - 239 (1999 ). The primers used for PCR of the 3′ portion of tb1 amplified a duplicate locus (tb1 homeologue) in two samples (11 and 16). Inclusion of these homeologous sequences caused π to r...
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Seeking, sometimes finding, that elusive chemistry
Despite all the discipline's achievements, opinion is divided as to whether chemistry is getting the recognition it deserves — and needs — in order to keep attracting new talent.
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Statistics hide impact of non-English journals
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Correction: Corrigendum: Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2
Nature 404, 298–302 (2000). In this Letter, we numbered some nucleotides for the upstream region of the reelin gene incorrectly. The Reelin-luc construct contains an upstream region of the reelin gene correspo...
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Open AccessUnique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing
Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pul...
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Open AccessThe genome sequence of the filamentous fungus Neurospora crassa
Neurospora crassa is a central organism in the history of twentieth-century genetics, biochemistry and molecular biology. Here, we report a high-quality draft sequence of the N. crassa genome. The approximately 4...
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Fruit bats as a natural reservoir of zoonotic viruses
As a natural reservoir of manifold zoonotic viruses, fruit bats have been involved in at least three emerging zoonoses in recent years. This paper aims to introduce the epidemiological characteristics of these...
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Design and application of 60mer oligonucleotide microarray in SARS coronavirus detection
The 60mer oligonucleotide microarray was designed and applied to detecting of SARS (severe acute respiratory syndrome) coronavirus. Thirty 60mer specific oligos were designed to cover the whole genome of the f...
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Cytotoxicity of HIV-gp41 segments expressed inE. coli
The failed attempt to express HIV-gp41 inE. coli led to the investigation of HIV-gp41 segments, which is responsible for the toxicity toE. coli cells. A series of deletion mutants containing different regions ofg...
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Modelling disease outbreaks in realistic urban social networks
Most mathematical models for the spread of disease use differential equations based on uniform mixing assumptions1 or ad hoc models for the contact process2,3,4. Here we explore the use of dynamic bipartite graph...
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Combined immunity of DNA vector and recombinant vaccinia virus expressing Gag proteins of equine infectious anemia virus
In order to develop a new vaccine candidate for equine infectious anemia virus (EIAV), gag gene of Chinese donkey leukocyte attenuated strain (EIAV DLV) and its parental virulent strain (EIAV LN) were inserted re...
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Open AccessThe genome of the protist parasite Entamoeba histolytica
The genome sequence of the pathogen Entamoeba histolytica is reported this week. E. histolytica causes amoebiasis, the second most deadly protozoan disease after malaria. The genome contains adaptations shared wi...
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Open AccessGenome sequencing in microfabricated high-density picolitre reactors
The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly parallel sequencing system with...