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Article
Open AccessTherapeutic potential of the secreted Kazal-type serine protease inhibitor SPINK4 in colitis
Mucus injury associated with goblet cell (GC) depletion constitutes an early event in inflammatory bowel disease (IBD). Using single-cell sequencing to detect critical events in mucus dysfunction, we discover ...
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Article
Hemorrhagic Shock and Resuscitation Causes Excessive Dopaminergic Signaling in the mPFC and Cognitive Dysfunction
Peri-operative hemorrhagic shock and resuscitation (HSR), a severe traumatic stress, is closely associated with post-operative anxiety, depression, and cognitive dysfunction, subsequently causing a serious bur...
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Article
Ammonia: An Emerging Gasotransmitter in Plant Growth and Response to Environmental Stress
Ammonia (NH3), which is an intermediate of nitrogen metabolism, has been found to be a gasotransmitter in plants. It has a dual physiological effect in a concentration-dependent manner, namely as a signaling mole...
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Article
Association of the serum levels of saturated fatty acids and mild cognitive impairment: a cross-sectional study
To investigate the association of serum saturated fatty acids (SFAs) and prevalent mild cognitive impairment (MCI) among middle-aged and elderly Chinese.
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Article
Open AccessSensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice
Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but the underlying molecular mechanism remains unclear. We demonstrate here that acid-sensing ion channel 3 (ASIC3) exacerb...
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Article
Open AccessAn ultra-short-acting benzodiazepine in thalamic nucleus reuniens undermines fear extinction via intermediation of hippocamposeptal circuits
Benzodiazepines, commonly used for anxiolytics, hinder conditioned fear extinction, and the underlying circuit mechanisms are unclear. Utilizing remimazolam, an ultra-short-acting benzodiazepine, here we revea...
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Article
Amorphous NiMo3S13/nickel foam integrated anode for lithium-ion batteries
Although crystalline anode materials with long-range ordered lattice structure are in favor of facilitating the electron transfer, their structures are easily disrupted during long-term cycling due to the cont...
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Article
Diagnostic accuracy of abdominal contrast-enhanced multi-slice spiral CT after oral diluted iodide in a time segment for gastrointestinal fistula in patients with severe acute pancreatitis
To evaluate the diagnostic accuracy of abdominal contrast-enhanced multi-slice spiral CT after oral diluted iodide in a time segment (post-ODI ACE-MSCT) for gastrointestinal fistula (GIF) in severe acute pancr...
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Article
Advances in ice avalanches on the Tibetan Plateau
As some of the greatest natural disasters in the cryosphere, ice avalanches (IAs) seriously threaten lives and cause catastrophic damage to the resource environment, but a comprehensive overview of the state o...
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Article
Jianpi Decoction Combined with Medroxyprogesterone Acetate Alleviates Cancer Cachexia and Prevents Muscle Atrophy by Directly Inhibiting E3 Ubiquitin Ligase
To provide comprehensive evidence for the anti-cancer cachexia effect of Jianpi Decoction (JP) and to explore its mechanism of anti-cancer cachexia.
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Article
Open AccessMemory Trace for Fear Extinction: Fragile yet Reinforceable
Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement, allowing the organism to re-adapt to ever-changing situations. Based on the behavioral hypot...
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Article
Open AccessCorrelation and risk factors of peripheral and cervicocephalic arterial atherosclerosis in patients with ischemic cerebrovascular disease
Patients with ischemic cerebrovascular disease (ICVD) frequently develop concomitant peripheral artery disease (PAD) or renal artery stenosis (RAS), and multiterritorial atherosclerotic patients usually have a...
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Article
Effects of calcitonin on lumbar spinal stenosis
Systematic review and meta-analysis.
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Article
Encoding learning network combined with feature similarity constraints for human action recognition
Extreme learning machine (ELM) is a fast and efficient classifier. Due to the inability to process descriptor-level features extracted from video sequences, the networks based on ELM cannot be directly used to...
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Article
Open AccessTeachers and educators’ experiences and perceptions of artificial-powered interventions for autism groups
Artificial intelligence-powered interventions have emerged as promising tools to support autistic individuals. However, more research must examine how teachers and educators perceive and experience these AI sy...
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Article
MiR-339-5p inhibits replication of porcine reproductive and respiratory syndrome virus by targeting viral gene regions
Porcine reproductive and respiratory syndrome virus (PRRSV) is a variable virus, whose spread cannot be totally stopped by vaccination. PRRSV infection results in abortion and respiratory symptoms in pregnant ...
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Article
An ASER AI/ML expert panel formative user research study for an interpretable interactive splenic AAST grading graphical user interface prototype
The AAST Organ Injury Scale is widely adopted for splenic injury severity but suffers from only moderate inter-rater agreement. This work assesses SpleenPro, a prototype interactive explainable artificial intelli...
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Article
Open AccessEnantioselective total synthesis of (‒)-lucidumone enabled by tandem prins cyclization/cycloetherification sequence
The Ganoderma meroterpenoids are a growing class of natural products with architectural complexity, and exhibit a wide range of biological activities. Here, we report an enantioselective total synthesis of the...
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Article
Open AccessHydraulic characterization and start-up of a novel circulating flow bio-carriers
High-quality biofilm carriers are crucial for the formation of biofilm, but problems such as slow biofilm growth on the carrier surface have been troubling a large number of researchers. The addition of a carr...
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Article
Open AccessRemnant cholesterol, iron status and diabetes mellitus: a dose–response relationship and mediation analysis
Remnant cholesterol (RC) is recognized as a risk factor for diabetes mellitus (DM). Although iron status has been shown to be associated with cholesterol metabolism and DM, the association between RC, iron sta...
