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Article
Maternal circadian rhythm disruption affects neonatal inflammation via metabolic reprograming of myeloid cells
Disruption of circadian rhythm during pregnancy produces adverse health outcomes in offspring; however, the role of maternal circadian rhythms in the immune system of infants and their susceptibility to inflam...
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Article
Open AccessUnraveling the causal genes and transcriptomic determinants of human telomere length
Telomere length (TL) shortening is a pivotal indicator of biological aging and is associated with many human diseases. The genetic determinates of human TL have been widely investigated, however, most existing...
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Article
Open AccessMaternal antibiotic exposure enhances ILC2 activation in neonates via downregulation of IFN1 signaling
Microbiota have an important function in sha** and priming neonatal immunity, although the cellular and molecular mechanisms underlying these effects remain obscure. Here we report that prenatal antibiotic e...
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Article
Open AccessLandscape of enhancer disruption and functional screen in melanoma cells
The high mutation rate throughout the entire melanoma genome presents a major challenge in stratifying true driver events from the background mutations. Numerous recurrent non-coding alterations, such as those...
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Article
Open AccessAssociation of laxatives use with incident dementia and modifying effect of genetic susceptibility: a population-based cohort study with propensity score matching
Constipation was associated with incidence of dementia and cognitive decline. Laxatives are the mainstay of constipation management and are commonly used among older populations for both treatment and preventi...
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Article
Open AccessAn autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin loo**
Genetic sharing is extensively observed for autoimmune diseases, but the causal variants and their underlying molecular mechanisms remain largely unknown. Through systematic investigation of autoimmune disease...
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Article
Open AccessEarly-life undernutrition induces enhancer RNA remodeling in mice liver
Maternal protein restriction diet (PRD) increases the risk of metabolic dysfunction in adulthood, the mechanisms during the early life of offspring are still poorly understood. Apart from genetic factors, epig...
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Article
Open AccessThe novel miR-1269b-regulated protein SVEP1 induces hepatocellular carcinoma proliferation and metastasis likely through the PI3K/Akt pathway
Decreased intercellular adhesion is a key step in the metastasis and recurrence of many cancers, including hepatocellular carcinoma (HCC). SVEP1 is an important cell adhesion molecule that plays a key role in ...
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Article
Open AccessDiversity spectrum analysis identifies mutation-specific effects of cancer driver genes
Mutation-specific effects of cancer driver genes influence drug responses and the success of clinical trials. We reasoned that these effects could unbalance the distribution of each mutation across different c...
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Article
Open AccessBody mass index and risk of lung cancer: Systematic review and dose-response meta-analysis
Questions remain about the significance of the dose-response relationship between body mass index (BMI) and lung cancer (LC) risk. Pertinent studies were identified through a search in EMBASE and PUBMED from J...
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Article
Open AccessExome sequencing identifies frequent mutation of MLL2 in non–small cell lung carcinoma from Chinese patients
Lung cancer is the most common cause of cancer mortality worldwide, with an estimated 1.4 million deaths each year. Here we report whole-exome sequencing of nine tumor/normal tissue pairs from Chinese patients...
